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Article: A Cancer-Targeted Nanosystem for Delivery of Gold(III) Complexes: Enhanced Selectivity and Apoptosis-Inducing Efficacy of a Gold(III) Porphyrin Complex

TitleA Cancer-Targeted Nanosystem for Delivery of Gold(III) Complexes: Enhanced Selectivity and Apoptosis-Inducing Efficacy of a Gold(III) Porphyrin Complex
Authors
Issue Date2014
PublisherWiley.
Citation
Angewandte Chemie International Edition, 2014, v. 53, p. 12532-12536 How to Cite?
AbstractConstruction of delivery systems for anticancer gold complexes to decrease their toxicity while maintaining efficacy is a key strategy to optimize and develop anticancer gold medicines. Herein, we describe cancer-targeted mesoporous silica nanoparticles (MSN) for delivery of a gold(III) porphyrin complex (Au-1 a@MSN(R)) to enhance its anticancer efficacy and selectivity between cancer and normal cells. Encapsulation of Au-1 a within mesoporous silica nanoparticles amplifies its inhibitory effects on thioredoxin reductase (TrxR), resulting in a loss of redox balance and overproduction of reactive oxygen species (ROS). Elevated cellular oxidative stress activates diversified downstream ROS-mediated signaling pathways, leading to enhanced apoptosis-inducing efficacy.
Persistent Identifierhttp://hdl.handle.net/10722/215135

 

DC FieldValueLanguage
dc.contributor.authorHe, L-
dc.contributor.authorChen, T-
dc.contributor.authorYou, Y-
dc.contributor.authorHu, H-
dc.contributor.authorZheng, W-
dc.contributor.authorKwong, WL-
dc.contributor.authorZou, T-
dc.contributor.authorChe, CM-
dc.date.accessioned2015-08-21T13:15:25Z-
dc.date.available2015-08-21T13:15:25Z-
dc.date.issued2014-
dc.identifier.citationAngewandte Chemie International Edition, 2014, v. 53, p. 12532-12536-
dc.identifier.urihttp://hdl.handle.net/10722/215135-
dc.description.abstractConstruction of delivery systems for anticancer gold complexes to decrease their toxicity while maintaining efficacy is a key strategy to optimize and develop anticancer gold medicines. Herein, we describe cancer-targeted mesoporous silica nanoparticles (MSN) for delivery of a gold(III) porphyrin complex (Au-1 a@MSN(R)) to enhance its anticancer efficacy and selectivity between cancer and normal cells. Encapsulation of Au-1 a within mesoporous silica nanoparticles amplifies its inhibitory effects on thioredoxin reductase (TrxR), resulting in a loss of redox balance and overproduction of reactive oxygen species (ROS). Elevated cellular oxidative stress activates diversified downstream ROS-mediated signaling pathways, leading to enhanced apoptosis-inducing efficacy.-
dc.languageeng-
dc.publisherWiley.-
dc.relation.ispartofAngewandte Chemie International Edition-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article]. In addition, authors may also transmit, print and share copies with colleagues, provided that there is no systematic distribution of the submitted version, e.g. posting on a listserve, network or automated delivery.-
dc.titleA Cancer-Targeted Nanosystem for Delivery of Gold(III) Complexes: Enhanced Selectivity and Apoptosis-Inducing Efficacy of a Gold(III) Porphyrin Complex-
dc.typeArticle-
dc.identifier.emailKwong, WL: kwongwl@hku.hk-
dc.identifier.emailZou, T: zoutt@hku.hk-
dc.identifier.emailChe, CM: cmche@hku.hk-
dc.identifier.authorityChe, CM=rp00670-
dc.identifier.doi10.1002/anie.201407143-
dc.identifier.hkuros246899-
dc.identifier.volume53-
dc.identifier.spage12532-
dc.identifier.epage12536-
dc.publisher.placeWeinheim, Germany-

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