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Article: The multifaceted and controversial immunometabolic actions of adiponectin

TitleThe multifaceted and controversial immunometabolic actions of adiponectin
Authors
Issue Date2014
Citation
Trends in Endocrinology & Metabolism, 2014, v. 25 n. 9, p. 444-451 How to Cite?
AbstractAdiponectin, one of the most abundant adipose-derived hormones, has variable actions in many tissues and organs. Although principally known for its insulin-sensitizing activity, recent data also highlight its homeostatic function, which is mediated both by direct actions on metabolic cells and indirectly through immunomodulatory effects on immune cells. Here we review the multifaceted immunometabolic actions of adiponectin and attempt to unify some of the contradictory reports on adiponectin function in inflammatory processes. We propose that a holistic understanding of adiponectin function can be garnered only from understanding its actions both on the immune system and on metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/214320

 

DC FieldValueLanguage
dc.contributor.authorEsmaili, S-
dc.contributor.authorXu, A-
dc.contributor.authorGeorge, J-
dc.date.accessioned2015-08-21T11:13:19Z-
dc.date.available2015-08-21T11:13:19Z-
dc.date.issued2014-
dc.identifier.citationTrends in Endocrinology & Metabolism, 2014, v. 25 n. 9, p. 444-451-
dc.identifier.urihttp://hdl.handle.net/10722/214320-
dc.description.abstractAdiponectin, one of the most abundant adipose-derived hormones, has variable actions in many tissues and organs. Although principally known for its insulin-sensitizing activity, recent data also highlight its homeostatic function, which is mediated both by direct actions on metabolic cells and indirectly through immunomodulatory effects on immune cells. Here we review the multifaceted immunometabolic actions of adiponectin and attempt to unify some of the contradictory reports on adiponectin function in inflammatory processes. We propose that a holistic understanding of adiponectin function can be garnered only from understanding its actions both on the immune system and on metabolism.-
dc.languageeng-
dc.relation.ispartofTrends in Endocrinology & Metabolism-
dc.titleThe multifaceted and controversial immunometabolic actions of adiponectin-
dc.typeArticle-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.authorityXu, A=rp00485-
dc.identifier.doi10.1016/j.tem.2014.06.001-
dc.identifier.hkuros246862-
dc.identifier.volume25-
dc.identifier.issue9-
dc.identifier.spage444-
dc.identifier.epage451-

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