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Article: Treatment of primary liver cancer using highly-conformal radiotherapy with kv-image guidance and respiratory control

TitleTreatment of primary liver cancer using highly-conformal radiotherapy with kv-image guidance and respiratory control
Authors
KeywordsLiver cancer
Respiratory control
Radiotherapy
Liver neoplasm
Image-guided radiotherapy
Hepatocellular
Carcinoma
Issue Date2012
Citation
Radiotherapy and Oncology, 2012, v. 102, n. 1, p. 56-61 How to Cite?
AbstractPurpose: To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients treated with high dose conformal radiotherapy using a commercially available treatment system. Materials and methods: CT stimulation was conducted under voluntary breath hold or gating using the Varian Real-time Position Management™ (RPM) System. Treatments were delivered daily under kV image guidance to verify the diaphragmatic or lipiodol-defined tumor position. Results: Thirty-three patients with liver confined hepatocellular carcinoma were treated between May 2006 and Dec 2009. After a median follow-up period of 16.5 months (range: 3.5-40.7), all but 2 patients demonstrated radiological tumor regression. Eight patients (24%) achieved complete remission. The median tumor shrinkage was 42% (27-100%). Subsequent in-field tumor progression was observed in only three patients (10%). For the 23 patients with abnormal alpha fetoprotein level, 22 of them showed biochemical response with a median AFP level drop of 78%. The treatment was well tolerated: Grade 3 toxicities occurred in 5 patients (1 leucopenia, 1 elevated liver enzyme and 3 elevated bilirubin level) but there was no grade 4 toxicity or treatment related death. The 1 year overall survival rate is 71.7% and median survival time is 17.2 months (3.5-40.7 months). Conclusions: Excellent treatment results with minimal toxicities could be achieved in a clinical environment with a commercially available highly sophisticated radiotherapy system. © 2011 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/213958
ISSN
2015 Impact Factor: 4.817
2015 SCImago Journal Rankings: 2.654

 

DC FieldValueLanguage
dc.contributor.authorLaw, Ada L Y-
dc.contributor.authorNg, Wai Tong-
dc.contributor.authorLee, Michael C H-
dc.contributor.authorChan, Augustine T S-
dc.contributor.authorFung, Kai Hung-
dc.contributor.authorLi, Francis-
dc.contributor.authorLao, Wai Cheung-
dc.contributor.authorLee, Anne W M-
dc.date.accessioned2015-08-19T13:41:22Z-
dc.date.available2015-08-19T13:41:22Z-
dc.date.issued2012-
dc.identifier.citationRadiotherapy and Oncology, 2012, v. 102, n. 1, p. 56-61-
dc.identifier.issn0167-8140-
dc.identifier.urihttp://hdl.handle.net/10722/213958-
dc.description.abstractPurpose: To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients treated with high dose conformal radiotherapy using a commercially available treatment system. Materials and methods: CT stimulation was conducted under voluntary breath hold or gating using the Varian Real-time Position Management™ (RPM) System. Treatments were delivered daily under kV image guidance to verify the diaphragmatic or lipiodol-defined tumor position. Results: Thirty-three patients with liver confined hepatocellular carcinoma were treated between May 2006 and Dec 2009. After a median follow-up period of 16.5 months (range: 3.5-40.7), all but 2 patients demonstrated radiological tumor regression. Eight patients (24%) achieved complete remission. The median tumor shrinkage was 42% (27-100%). Subsequent in-field tumor progression was observed in only three patients (10%). For the 23 patients with abnormal alpha fetoprotein level, 22 of them showed biochemical response with a median AFP level drop of 78%. The treatment was well tolerated: Grade 3 toxicities occurred in 5 patients (1 leucopenia, 1 elevated liver enzyme and 3 elevated bilirubin level) but there was no grade 4 toxicity or treatment related death. The 1 year overall survival rate is 71.7% and median survival time is 17.2 months (3.5-40.7 months). Conclusions: Excellent treatment results with minimal toxicities could be achieved in a clinical environment with a commercially available highly sophisticated radiotherapy system. © 2011 Elsevier Ireland Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofRadiotherapy and Oncology-
dc.subjectLiver cancer-
dc.subjectRespiratory control-
dc.subjectRadiotherapy-
dc.subjectLiver neoplasm-
dc.subjectImage-guided radiotherapy-
dc.subjectHepatocellular-
dc.subjectCarcinoma-
dc.titleTreatment of primary liver cancer using highly-conformal radiotherapy with kv-image guidance and respiratory control-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.radonc.2011.05.022-
dc.identifier.pmid21640423-
dc.identifier.scopuseid_2-s2.0-84455161150-
dc.identifier.hkuros266358-
dc.identifier.volume102-
dc.identifier.issue1-
dc.identifier.spage56-
dc.identifier.epage61-
dc.identifier.eissn1879-0887-

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