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Article: Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for nasopharyngeal carcinoma

TitleClinical outcomes and patterns of failure after intensity-modulated radiotherapy for nasopharyngeal carcinoma
Authors
KeywordsIMRT
Nasopharyngeal carcinoma
Pattern of failure
Intensity-modulated radiotherapy
Issue Date2011
Citation
International Journal of Radiation Oncology - Biology - Physics, 2011, v. 79, n. 2, p. 420-428 How to Cite?
AbstractPurpose: To study and report the clinical outcomes and patterns of failure after intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC). Methods and Materials: The treatment outcomes of NPC patients treated with IMRT at Pamela Youde Nethersole Eastern Hospital between 2005 and 2007 were reviewed. The location and extent of locoregional failures were transferred to the pretreatment planning computed tomography for dosimetry analysis. Statistical analyses were performed on dose coverage and locoregional failures. Results: A total of 193 NPC patients were analyzed; 93% had Stage III/IV disease. Median follow-up was 30 months. Overall disease failure (at any site) developed in 35 patients. Among these, there were 23 distant metastases, 16 local failures, and 9 regional failures. Four of the locoregional failures were marginal. Dose conformity with IMRT was excellent. Patients with at least 66.5 Gy to their target volumes had significantly less locoregional failure. The 2-year local progression-free, regional progression-free, distant metastasis-free, and overall survival rates were 95%, 96%, 90%, and 92%, respectively. Conclusions: Intensity-modulated radiotherapy provides excellent locoregional control for NPC. Distant metastasis remains the most difficult challenge, and more effective systemic agents should be explored for patients presenting with advanced locoregional diseases. Copyright © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/213941
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274

 

DC FieldValueLanguage
dc.contributor.authorNg, Wai Tong-
dc.contributor.authorLee, Michael C H-
dc.contributor.authorHung, Wai Man-
dc.contributor.authorChoi, Cheuk Wai-
dc.contributor.authorLee, Kin Chung-
dc.contributor.authorChan, Oscar S H-
dc.contributor.authorLee, Anne W M-
dc.date.accessioned2015-08-19T13:41:18Z-
dc.date.available2015-08-19T13:41:18Z-
dc.date.issued2011-
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 2011, v. 79, n. 2, p. 420-428-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/213941-
dc.description.abstractPurpose: To study and report the clinical outcomes and patterns of failure after intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC). Methods and Materials: The treatment outcomes of NPC patients treated with IMRT at Pamela Youde Nethersole Eastern Hospital between 2005 and 2007 were reviewed. The location and extent of locoregional failures were transferred to the pretreatment planning computed tomography for dosimetry analysis. Statistical analyses were performed on dose coverage and locoregional failures. Results: A total of 193 NPC patients were analyzed; 93% had Stage III/IV disease. Median follow-up was 30 months. Overall disease failure (at any site) developed in 35 patients. Among these, there were 23 distant metastases, 16 local failures, and 9 regional failures. Four of the locoregional failures were marginal. Dose conformity with IMRT was excellent. Patients with at least 66.5 Gy to their target volumes had significantly less locoregional failure. The 2-year local progression-free, regional progression-free, distant metastasis-free, and overall survival rates were 95%, 96%, 90%, and 92%, respectively. Conclusions: Intensity-modulated radiotherapy provides excellent locoregional control for NPC. Distant metastasis remains the most difficult challenge, and more effective systemic agents should be explored for patients presenting with advanced locoregional diseases. Copyright © 2011 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physics-
dc.subjectIMRT-
dc.subjectNasopharyngeal carcinoma-
dc.subjectPattern of failure-
dc.subjectIntensity-modulated radiotherapy-
dc.titleClinical outcomes and patterns of failure after intensity-modulated radiotherapy for nasopharyngeal carcinoma-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2009.11.024-
dc.identifier.pmid20452132-
dc.identifier.scopuseid_2-s2.0-78650838398-
dc.identifier.hkuros266253-
dc.identifier.volume79-
dc.identifier.issue2-
dc.identifier.spage420-
dc.identifier.epage428-

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