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Article: Impact of adjuvant chemoradiation for adenocarcinoma of stomach after curative gastrectomy in Chinese: A 7-year audit

TitleImpact of adjuvant chemoradiation for adenocarcinoma of stomach after curative gastrectomy in Chinese: A 7-year audit
Authors
KeywordsAdjuvant therapy
Stomach cancer
Radiotherapy
Gastrectomy
Chemotherapy
Issue Date2010
Citation
Surgical Practice, 2010, v. 14, n. 3, p. 85-91 How to Cite?
AbstractBackground and Aim: Adjuvant chemoradiation (CRT) after curative gastrectomy was introduced to our hospital in 1998. The present study aims to examine the impact of CRT on survival among Chinese. Methods: From our gastric cancer registry, patients who received R0 gastrectomy, with UICC stage II or above, M0 disease and ASA grades I and II were analyzed. Adjuvant CRT was offered and given if patients agreed. The regimen consisted of five cycles of 5-fluoruracil (5FU)/leucovorin chemotherapy and 45 Gy/25 fractions concurrent with cycles 2 and 3. Results: From January 1998 to December 2004, 134 patients fulfilled the criteria. Sixty had surgery alone and 74 patients received CRT after gastrectomy. One hundred and two (76%) patients received radical gastrectomy with D2 lymphadenectomy. Toxicity ≥ grade 3 was seen in 65% of patients without mortality. The overall and relapse-free 5-year survival rates were 45.8% and 42.0%, respectively. On univariate analysis, early disease stage and adjuvant CRT were associated with better prognosis. Cox regression analysis showed that adjuvant CRT (P = 0.01, HR 2.31, 95% CI: 1.4-3.9) predict better survival after adjustment with the other factors. Conclusion: In the present study, postoperative adjuvant chemoradiation is associated with better overall survival in patients with adenocarcinoma of the stomach after curative gastrectomy. © 2010 The Authors. Journal compilation © 2010 College of Surgeons of Hong Kong.
Persistent Identifierhttp://hdl.handle.net/10722/213934
ISSN
2013 Impact Factor: 0.172
2015 SCImago Journal Rankings: 0.121

 

DC FieldValueLanguage
dc.contributor.authorNg, Dennis Chung Kei-
dc.contributor.authorWong, Simon Kin Hung-
dc.contributor.authorNg, Wai Tong-
dc.contributor.authorLee, Anne Wing Mui-
dc.contributor.authorLi, Michael Ka Wah-
dc.date.accessioned2015-08-19T13:41:16Z-
dc.date.available2015-08-19T13:41:16Z-
dc.date.issued2010-
dc.identifier.citationSurgical Practice, 2010, v. 14, n. 3, p. 85-91-
dc.identifier.issn1744-1625-
dc.identifier.urihttp://hdl.handle.net/10722/213934-
dc.description.abstractBackground and Aim: Adjuvant chemoradiation (CRT) after curative gastrectomy was introduced to our hospital in 1998. The present study aims to examine the impact of CRT on survival among Chinese. Methods: From our gastric cancer registry, patients who received R0 gastrectomy, with UICC stage II or above, M0 disease and ASA grades I and II were analyzed. Adjuvant CRT was offered and given if patients agreed. The regimen consisted of five cycles of 5-fluoruracil (5FU)/leucovorin chemotherapy and 45 Gy/25 fractions concurrent with cycles 2 and 3. Results: From January 1998 to December 2004, 134 patients fulfilled the criteria. Sixty had surgery alone and 74 patients received CRT after gastrectomy. One hundred and two (76%) patients received radical gastrectomy with D2 lymphadenectomy. Toxicity ≥ grade 3 was seen in 65% of patients without mortality. The overall and relapse-free 5-year survival rates were 45.8% and 42.0%, respectively. On univariate analysis, early disease stage and adjuvant CRT were associated with better prognosis. Cox regression analysis showed that adjuvant CRT (P = 0.01, HR 2.31, 95% CI: 1.4-3.9) predict better survival after adjustment with the other factors. Conclusion: In the present study, postoperative adjuvant chemoradiation is associated with better overall survival in patients with adenocarcinoma of the stomach after curative gastrectomy. © 2010 The Authors. Journal compilation © 2010 College of Surgeons of Hong Kong.-
dc.languageeng-
dc.relation.ispartofSurgical Practice-
dc.subjectAdjuvant therapy-
dc.subjectStomach cancer-
dc.subjectRadiotherapy-
dc.subjectGastrectomy-
dc.subjectChemotherapy-
dc.titleImpact of adjuvant chemoradiation for adenocarcinoma of stomach after curative gastrectomy in Chinese: A 7-year audit-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1744-1633.2010.00504.x-
dc.identifier.scopuseid_2-s2.0-77955151549-
dc.identifier.hkuros266206-
dc.identifier.volume14-
dc.identifier.issue3-
dc.identifier.spage85-
dc.identifier.epage91-
dc.identifier.eissn1744-1633-

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