File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1111/j.1744-1633.2010.00504.x
- Scopus: eid_2-s2.0-77955151549
- WOS: WOS:000280195700003
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Impact of adjuvant chemoradiation for adenocarcinoma of stomach after curative gastrectomy in Chinese: A 7-year audit
Title | Impact of adjuvant chemoradiation for adenocarcinoma of stomach after curative gastrectomy in Chinese: A 7-year audit |
---|---|
Authors | |
Keywords | Adjuvant therapy Stomach cancer Radiotherapy Gastrectomy Chemotherapy |
Issue Date | 2010 |
Citation | Surgical Practice, 2010, v. 14, n. 3, p. 85-91 How to Cite? |
Abstract | Background and Aim: Adjuvant chemoradiation (CRT) after curative gastrectomy was introduced to our hospital in 1998. The present study aims to examine the impact of CRT on survival among Chinese. Methods: From our gastric cancer registry, patients who received R0 gastrectomy, with UICC stage II or above, M0 disease and ASA grades I and II were analyzed. Adjuvant CRT was offered and given if patients agreed. The regimen consisted of five cycles of 5-fluoruracil (5FU)/leucovorin chemotherapy and 45 Gy/25 fractions concurrent with cycles 2 and 3. Results: From January 1998 to December 2004, 134 patients fulfilled the criteria. Sixty had surgery alone and 74 patients received CRT after gastrectomy. One hundred and two (76%) patients received radical gastrectomy with D2 lymphadenectomy. Toxicity ≥ grade 3 was seen in 65% of patients without mortality. The overall and relapse-free 5-year survival rates were 45.8% and 42.0%, respectively. On univariate analysis, early disease stage and adjuvant CRT were associated with better prognosis. Cox regression analysis showed that adjuvant CRT (P = 0.01, HR 2.31, 95% CI: 1.4-3.9) predict better survival after adjustment with the other factors. Conclusion: In the present study, postoperative adjuvant chemoradiation is associated with better overall survival in patients with adenocarcinoma of the stomach after curative gastrectomy. © 2010 The Authors. Journal compilation © 2010 College of Surgeons of Hong Kong. |
Persistent Identifier | http://hdl.handle.net/10722/213934 |
ISSN | 2023 Impact Factor: 0.3 2023 SCImago Journal Rankings: 0.152 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ng, Dennis Chung Kei | - |
dc.contributor.author | Wong, Simon Kin Hung | - |
dc.contributor.author | Ng, Wai Tong | - |
dc.contributor.author | Lee, Anne Wing Mui | - |
dc.contributor.author | Li, Michael Ka Wah | - |
dc.date.accessioned | 2015-08-19T13:41:16Z | - |
dc.date.available | 2015-08-19T13:41:16Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Surgical Practice, 2010, v. 14, n. 3, p. 85-91 | - |
dc.identifier.issn | 1744-1625 | - |
dc.identifier.uri | http://hdl.handle.net/10722/213934 | - |
dc.description.abstract | Background and Aim: Adjuvant chemoradiation (CRT) after curative gastrectomy was introduced to our hospital in 1998. The present study aims to examine the impact of CRT on survival among Chinese. Methods: From our gastric cancer registry, patients who received R0 gastrectomy, with UICC stage II or above, M0 disease and ASA grades I and II were analyzed. Adjuvant CRT was offered and given if patients agreed. The regimen consisted of five cycles of 5-fluoruracil (5FU)/leucovorin chemotherapy and 45 Gy/25 fractions concurrent with cycles 2 and 3. Results: From January 1998 to December 2004, 134 patients fulfilled the criteria. Sixty had surgery alone and 74 patients received CRT after gastrectomy. One hundred and two (76%) patients received radical gastrectomy with D2 lymphadenectomy. Toxicity ≥ grade 3 was seen in 65% of patients without mortality. The overall and relapse-free 5-year survival rates were 45.8% and 42.0%, respectively. On univariate analysis, early disease stage and adjuvant CRT were associated with better prognosis. Cox regression analysis showed that adjuvant CRT (P = 0.01, HR 2.31, 95% CI: 1.4-3.9) predict better survival after adjustment with the other factors. Conclusion: In the present study, postoperative adjuvant chemoradiation is associated with better overall survival in patients with adenocarcinoma of the stomach after curative gastrectomy. © 2010 The Authors. Journal compilation © 2010 College of Surgeons of Hong Kong. | - |
dc.language | eng | - |
dc.relation.ispartof | Surgical Practice | - |
dc.subject | Adjuvant therapy | - |
dc.subject | Stomach cancer | - |
dc.subject | Radiotherapy | - |
dc.subject | Gastrectomy | - |
dc.subject | Chemotherapy | - |
dc.title | Impact of adjuvant chemoradiation for adenocarcinoma of stomach after curative gastrectomy in Chinese: A 7-year audit | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1744-1633.2010.00504.x | - |
dc.identifier.scopus | eid_2-s2.0-77955151549 | - |
dc.identifier.hkuros | 266206 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 85 | - |
dc.identifier.epage | 91 | - |
dc.identifier.eissn | 1744-1633 | - |
dc.identifier.isi | WOS:000280195700003 | - |
dc.identifier.issnl | 1744-1625 | - |