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Article: Potential improvement of tumor control probability by induction chemotherapy for advanced nasopharyngeal carcinoma

TitlePotential improvement of tumor control probability by induction chemotherapy for advanced nasopharyngeal carcinoma
Authors
KeywordsNasopharyngeal cancer
Induction chemotherapy
Tumor control probability
Issue Date2008
Citation
Radiotherapy and Oncology, 2008, v. 87, n. 2, p. 204-210 How to Cite?
AbstractPurpose: To assess the reduction of tumor bulk and improvement of tumor control probability (TCP) by using induction chemotherapy for advanced nasopharyngeal carcinoma (NPC). Materials and methods: From February to December 2005, 20 patients with Stage III-IVB NPC were treated with induction-concurrent chemotherapy and intensity-modulated radiotherapy with accelerated fractionation. Combination of cisplatin and 5-fluorouracil was used in the induction phase and single agent Cisplatin in the concurrent phase. All patients were irradiated at 2 Gy per fraction, 6 daily fractions per week, to a total dose of 70 Gy. Results: Nineteen (95%) patients completed all 3 cycles of induction chemotherapy and 90% had ≥2 cycles of concurrent chemotherapy. Induction chemotherapy achieved significant down-staging of T-category in 35% of patients (p = 0.016) and reduction of gross tumor volume (GTV_P) from 55.6 to 22.9 cc (mean 61.4%, p < 0.001). Although the mean radiation dose did not show any substantial change, the volume within GTV_P that failed to reach 70 Gy was reduced from 10.2% to 3.8% (p = 0.017). The estimated local TCP increased from 0.83 to 0.89 (p = 0.002). Conclusions: Induction chemotherapy using cisplatin-5-fluorouracil could significantly reduce tumor bulk leading to potential improvement in tumor control. © 2008 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/213914
ISSN
2015 Impact Factor: 4.817
2015 SCImago Journal Rankings: 2.654

 

DC FieldValueLanguage
dc.contributor.authorLee, A. W M-
dc.contributor.authorLau, Kam Ying-
dc.contributor.authorHung, Wai Man-
dc.contributor.authorNg, Wai Tong-
dc.contributor.authorLee, M. C H-
dc.contributor.authorChoi, Cheuk Wai-
dc.contributor.authorChan, C. C C-
dc.contributor.authorTung, Raymond-
dc.contributor.authorCheng, P. T C-
dc.contributor.authorYau, Tsz Kok-
dc.date.accessioned2015-08-19T13:41:12Z-
dc.date.available2015-08-19T13:41:12Z-
dc.date.issued2008-
dc.identifier.citationRadiotherapy and Oncology, 2008, v. 87, n. 2, p. 204-210-
dc.identifier.issn0167-8140-
dc.identifier.urihttp://hdl.handle.net/10722/213914-
dc.description.abstractPurpose: To assess the reduction of tumor bulk and improvement of tumor control probability (TCP) by using induction chemotherapy for advanced nasopharyngeal carcinoma (NPC). Materials and methods: From February to December 2005, 20 patients with Stage III-IVB NPC were treated with induction-concurrent chemotherapy and intensity-modulated radiotherapy with accelerated fractionation. Combination of cisplatin and 5-fluorouracil was used in the induction phase and single agent Cisplatin in the concurrent phase. All patients were irradiated at 2 Gy per fraction, 6 daily fractions per week, to a total dose of 70 Gy. Results: Nineteen (95%) patients completed all 3 cycles of induction chemotherapy and 90% had ≥2 cycles of concurrent chemotherapy. Induction chemotherapy achieved significant down-staging of T-category in 35% of patients (p = 0.016) and reduction of gross tumor volume (GTV_P) from 55.6 to 22.9 cc (mean 61.4%, p < 0.001). Although the mean radiation dose did not show any substantial change, the volume within GTV_P that failed to reach 70 Gy was reduced from 10.2% to 3.8% (p = 0.017). The estimated local TCP increased from 0.83 to 0.89 (p = 0.002). Conclusions: Induction chemotherapy using cisplatin-5-fluorouracil could significantly reduce tumor bulk leading to potential improvement in tumor control. © 2008 Elsevier Ireland Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofRadiotherapy and Oncology-
dc.subjectNasopharyngeal cancer-
dc.subjectInduction chemotherapy-
dc.subjectTumor control probability-
dc.titlePotential improvement of tumor control probability by induction chemotherapy for advanced nasopharyngeal carcinoma-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.radonc.2008.02.003-
dc.identifier.pmid18329742-
dc.identifier.scopuseid_2-s2.0-43049175165-
dc.identifier.hkuros266128-
dc.identifier.volume87-
dc.identifier.issue2-
dc.identifier.spage204-
dc.identifier.epage210-

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