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Article: N-staging by magnetic resonance imaging for patients with nasopharyngeal carcinoma: Pattern of nodal involvement by radiological levels

TitleN-staging by magnetic resonance imaging for patients with nasopharyngeal carcinoma: Pattern of nodal involvement by radiological levels
Authors
KeywordsNasopharyngeal carcinoma
Cervical metastases
Retropharyngeal lymph node
Magnetic resonance imaging
Issue Date2007
Citation
Radiotherapy and Oncology, 2007, v. 82, n. 1, p. 70-75 How to Cite?
AbstractBackground and purpose: To study the pattern of lymphatic spread for patients with nasopharyngeal carcinoma (NPC), the significance of retropharyngeal node (RP-LN) involvement, and the possibility of replacing the supraclavicular fossa (SCF) by Levels IV and Vb (LL) as a demarcating criterion for N3-category. Patients and methods: The magnetic resonance imagings (MRI) of 202 consecutive patients with NPC treated during 2001-2002 were retrospectively reviewed. Distribution in terms of radiological level (using the same criteria as other head and neck cancers) was mapped, and the size of individual node measured. Prognostic significance of RP-LN and LL was analyzed. Results: Only 4% of patients were node-negative on presentation. The nodal involvement occurred predominately at II (94%), III (85%) and RP-LN (80%). The presence of RP-LN affected the N-category in 3.5% of patients, and had no significant impact on tumor control. Replacing SCF by LL as one of the criteria for defining N3 is predictive for both distant control and overall survival. Conclusions: With sensitive detection by MRI, the incidence of nodal involvement was very high for patients with NPC. It was difficult to isolate the prognostic significance of RP-LN. The current criterion for defining N3-category by extension into SCF or nodal size >6 cm is the recommended standard, however replacing SCF with LL could be potentially useful and further validation is warranted. © 2006 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/213905
ISSN
2015 Impact Factor: 4.817
2015 SCImago Journal Rankings: 2.654

 

DC FieldValueLanguage
dc.contributor.authorNg, Wai T.-
dc.contributor.authorLee, Anne W M-
dc.contributor.authorKan, Wai K.-
dc.contributor.authorChan, John-
dc.contributor.authorPang, Ellie S Y-
dc.contributor.authorYau, Tsz K.-
dc.contributor.authorLau, Kam Y.-
dc.date.accessioned2015-08-19T13:41:10Z-
dc.date.available2015-08-19T13:41:10Z-
dc.date.issued2007-
dc.identifier.citationRadiotherapy and Oncology, 2007, v. 82, n. 1, p. 70-75-
dc.identifier.issn0167-8140-
dc.identifier.urihttp://hdl.handle.net/10722/213905-
dc.description.abstractBackground and purpose: To study the pattern of lymphatic spread for patients with nasopharyngeal carcinoma (NPC), the significance of retropharyngeal node (RP-LN) involvement, and the possibility of replacing the supraclavicular fossa (SCF) by Levels IV and Vb (LL) as a demarcating criterion for N3-category. Patients and methods: The magnetic resonance imagings (MRI) of 202 consecutive patients with NPC treated during 2001-2002 were retrospectively reviewed. Distribution in terms of radiological level (using the same criteria as other head and neck cancers) was mapped, and the size of individual node measured. Prognostic significance of RP-LN and LL was analyzed. Results: Only 4% of patients were node-negative on presentation. The nodal involvement occurred predominately at II (94%), III (85%) and RP-LN (80%). The presence of RP-LN affected the N-category in 3.5% of patients, and had no significant impact on tumor control. Replacing SCF by LL as one of the criteria for defining N3 is predictive for both distant control and overall survival. Conclusions: With sensitive detection by MRI, the incidence of nodal involvement was very high for patients with NPC. It was difficult to isolate the prognostic significance of RP-LN. The current criterion for defining N3-category by extension into SCF or nodal size >6 cm is the recommended standard, however replacing SCF with LL could be potentially useful and further validation is warranted. © 2006 Elsevier Ireland Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofRadiotherapy and Oncology-
dc.subjectNasopharyngeal carcinoma-
dc.subjectCervical metastases-
dc.subjectRetropharyngeal lymph node-
dc.subjectMagnetic resonance imaging-
dc.titleN-staging by magnetic resonance imaging for patients with nasopharyngeal carcinoma: Pattern of nodal involvement by radiological levels-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.radonc.2006.11.010-
dc.identifier.pmid17166610-
dc.identifier.scopuseid_2-s2.0-33846281890-
dc.identifier.hkuros266123-
dc.identifier.volume82-
dc.identifier.issue1-
dc.identifier.spage70-
dc.identifier.epage75-

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