File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Staging of nasopharyngeal carcinoma: Evaluation of N-staging by Ho and UICC/AJCC systems

TitleStaging of nasopharyngeal carcinoma: Evaluation of N-staging by Ho and UICC/AJCC systems
Authors
KeywordsNasopharyngeal carcinoma
N-staging systems
Issue Date1996
Citation
Clinical Oncology, 1996, v. 8, n. 3, p. 146-154 How to Cite?
AbstractTo evaluate the prognostic accuracy of N-staging by Ho's and the UICC/AJCC systems, 5020 patients with undifferentiated or poorly differentiated squamous cell carcinoma of the nasopharynx treated at the Queen Elizabeth Hospital, Hong Kong in the period 1976-1985 were analysed retrospectively. They were initially staged with Ho's system, but detailed records of nodal involvement allowed accurate retrospective restaging with the UICC/AJCC system. Staging assessment depended almost entirely on physical examination; only 14% of patients had additional investigations with computed tomography. To evaluate the independent significance of different nodal parameters, T-stage adjusted analyses of the 4730 patients presenting without distant metastases were performed. Both N-staging systems showed a strongly significant overall correlation with distant failures and cancer-specific deaths. A significant trend was also shown for nodal failures in node-positive patients. Ho's system was superior in predicting distant failures, while the UICC/AJCC system was superior for nodal failures. However, even with due adjustment for level, the independent significance of nodal size, laterality and fixity could be demonstrated. After adjustment for UICC/AJCC N-stage, both level and fixity were also significant. Furthermore, when adjusted for all other meaningful parameters, there were no significant differences between ipsilateral and contralateral involvement, upper and mid-level extent, and nodal size ≤ 3 cm or > 3- ≤ 6 cm. N-staging can be further optimized by a newly proposed system incorporating fixity (movable versus fixed), level (upper-mid versus lower), size (greatest diameter ≤ 6 cm versus > 6 cm), and laterality (unilateral versus bilateral) as staging criteria.
Persistent Identifierhttp://hdl.handle.net/10722/213856
ISSN
2015 Impact Factor: 3.212
2015 SCImago Journal Rankings: 1.194

 

DC FieldValueLanguage
dc.contributor.authorLee, A. W M-
dc.contributor.authorFoo, W.-
dc.contributor.authorPoon, Y. F.-
dc.contributor.authorLaw, C. K.-
dc.contributor.authorChan, D. K K-
dc.contributor.authorO, S. K.-
dc.contributor.authorTung, S. Y.-
dc.contributor.authorHo, J. H C-
dc.date.accessioned2015-08-19T13:40:58Z-
dc.date.available2015-08-19T13:40:58Z-
dc.date.issued1996-
dc.identifier.citationClinical Oncology, 1996, v. 8, n. 3, p. 146-154-
dc.identifier.issn0936-6555-
dc.identifier.urihttp://hdl.handle.net/10722/213856-
dc.description.abstractTo evaluate the prognostic accuracy of N-staging by Ho's and the UICC/AJCC systems, 5020 patients with undifferentiated or poorly differentiated squamous cell carcinoma of the nasopharynx treated at the Queen Elizabeth Hospital, Hong Kong in the period 1976-1985 were analysed retrospectively. They were initially staged with Ho's system, but detailed records of nodal involvement allowed accurate retrospective restaging with the UICC/AJCC system. Staging assessment depended almost entirely on physical examination; only 14% of patients had additional investigations with computed tomography. To evaluate the independent significance of different nodal parameters, T-stage adjusted analyses of the 4730 patients presenting without distant metastases were performed. Both N-staging systems showed a strongly significant overall correlation with distant failures and cancer-specific deaths. A significant trend was also shown for nodal failures in node-positive patients. Ho's system was superior in predicting distant failures, while the UICC/AJCC system was superior for nodal failures. However, even with due adjustment for level, the independent significance of nodal size, laterality and fixity could be demonstrated. After adjustment for UICC/AJCC N-stage, both level and fixity were also significant. Furthermore, when adjusted for all other meaningful parameters, there were no significant differences between ipsilateral and contralateral involvement, upper and mid-level extent, and nodal size ≤ 3 cm or > 3- ≤ 6 cm. N-staging can be further optimized by a newly proposed system incorporating fixity (movable versus fixed), level (upper-mid versus lower), size (greatest diameter ≤ 6 cm versus > 6 cm), and laterality (unilateral versus bilateral) as staging criteria.-
dc.languageeng-
dc.relation.ispartofClinical Oncology-
dc.subjectNasopharyngeal carcinoma-
dc.subjectN-staging systems-
dc.titleStaging of nasopharyngeal carcinoma: Evaluation of N-staging by Ho and UICC/AJCC systems-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0936-6555(96)80038-0-
dc.identifier.pmid8814368-
dc.identifier.scopuseid_2-s2.0-0030016020-
dc.identifier.hkuros265847-
dc.identifier.volume8-
dc.identifier.issue3-
dc.identifier.spage146-
dc.identifier.epage154-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats