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Article: Effect of time, dose and fractionation on local control of nasopharyngeal carcinoma

TitleEffect of time, dose and fractionation on local control of nasopharyngeal carcinoma
Authors
KeywordsLocal control
Time
Fractionation
Nasopharyngeal carcinoma
Dose
Biological equivalent formulae
Issue Date1995
Citation
Radiotherapy and Oncology, 1995, v. 36, n. 1, p. 24-31 How to Cite?
AbstractTo study the effect of radiation factors on local control of nasopharyngeal carcinoma, 1008 patients with similarly staged T1N0-3M0 disease (Ho's classification) were retrospectively analyzed. All patients were treated by megavoltage irradiation alone using the same technique. Four different fractionation schedules had been used sequentially during 1976-1985: with total dose ranging from 45.6 to 60 Gy and fractional dose from 2.5 to 4.2 Gy. The median overall time was 39 days (range = 38-75 days). Both for the whole series and 763 patients with nodal control, total dose was the most important radiation factor. The hazard of local failure decreased by 9% per additional Gy (p < 0.01). Biological equivalents expressed in terms of Biologically Effective Dose or Nominal Standard Dose also showed strong correlation. Fractional dose had no significant impact. The effect of overall treatment time was insignificant for the whole series, but almost reached statistical significance for those with nodal control (p = 0.06). Further study is required for elucidation, as 85% of patients completed treatment within a very narrow range (38-42 days), and the possible hazard is clinically too significant to be ignored. © 1995.
Persistent Identifierhttp://hdl.handle.net/10722/213855
ISSN
2015 Impact Factor: 4.817
2015 SCImago Journal Rankings: 2.654

 

DC FieldValueLanguage
dc.contributor.authorLee, Anne W M-
dc.contributor.authorChan, David K K-
dc.contributor.authorFowler, Jack F.-
dc.contributor.authorPoon, Y. F.-
dc.contributor.authorFoo, William-
dc.contributor.authorLaw, Stephen C K-
dc.contributor.authorO, S. K.-
dc.contributor.authorTung, Stewart Y.-
dc.contributor.authorChappell, Rick-
dc.date.accessioned2015-08-19T13:40:58Z-
dc.date.available2015-08-19T13:40:58Z-
dc.date.issued1995-
dc.identifier.citationRadiotherapy and Oncology, 1995, v. 36, n. 1, p. 24-31-
dc.identifier.issn0167-8140-
dc.identifier.urihttp://hdl.handle.net/10722/213855-
dc.description.abstractTo study the effect of radiation factors on local control of nasopharyngeal carcinoma, 1008 patients with similarly staged T1N0-3M0 disease (Ho's classification) were retrospectively analyzed. All patients were treated by megavoltage irradiation alone using the same technique. Four different fractionation schedules had been used sequentially during 1976-1985: with total dose ranging from 45.6 to 60 Gy and fractional dose from 2.5 to 4.2 Gy. The median overall time was 39 days (range = 38-75 days). Both for the whole series and 763 patients with nodal control, total dose was the most important radiation factor. The hazard of local failure decreased by 9% per additional Gy (p < 0.01). Biological equivalents expressed in terms of Biologically Effective Dose or Nominal Standard Dose also showed strong correlation. Fractional dose had no significant impact. The effect of overall treatment time was insignificant for the whole series, but almost reached statistical significance for those with nodal control (p = 0.06). Further study is required for elucidation, as 85% of patients completed treatment within a very narrow range (38-42 days), and the possible hazard is clinically too significant to be ignored. © 1995.-
dc.languageeng-
dc.relation.ispartofRadiotherapy and Oncology-
dc.subjectLocal control-
dc.subjectTime-
dc.subjectFractionation-
dc.subjectNasopharyngeal carcinoma-
dc.subjectDose-
dc.subjectBiological equivalent formulae-
dc.titleEffect of time, dose and fractionation on local control of nasopharyngeal carcinoma-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0167-8140(95)01579-6-
dc.identifier.pmid8525022-
dc.identifier.scopuseid_2-s2.0-0029075950-
dc.identifier.hkuros265842-
dc.identifier.volume36-
dc.identifier.issue1-
dc.identifier.spage24-
dc.identifier.epage31-

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