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Article: Nasopharyngeal carcinoma: Local control by megavoltage irradiation

TitleNasopharyngeal carcinoma: Local control by megavoltage irradiation
Authors
Issue Date1993
Citation
British Journal of Radiology, 1993, v. 66, n. 786, p. 528-536 How to Cite?
AbstractThis is a retrospective analysis of the long-term local control in 4128 patients with non-disseminated nasopharyngeal carcinoma treated solely by megavoltage irradiation during the years 1976-1985. The T-stage distribution according to Ho's classification was T1 37%, T2 14% and T3 49%. Different fractionation schedules had been employed at different periods, and the median dose to the primary target was equivalent to 65 Gy by time dose fractionation calculation. In 8% (344) of patients the tumour failed to regress completely after the basic course, but 89% (148/167) of those suitable for salvage with additional irradiation eventually attained complete local remission. The cumulative incidence of local failure was 24% (5% persistence, 19% recurrence). The 10-year actuarial local failure-free survival was 67%. While patients with T2 and T3a tumours achieved local control comparable to T1, those with T3c-d had the poorest control (with highest incidence of persistence and advanced recurrence). T-stage adjusted analyses suggested a significant trend of dose-response: the odds ratios for local failure were 1.16 and 1.86, respectively, when patients given 60-63 Gy and 55-59 Gy were compared with those given 64 Gy or above (p value = 0.0018). Patients treated during 1981-1985 achieved higher local failure-free survival than those treated during 1976-1980 (75% versus 70% at 5 years, p value = 0.0013). The possible attributes are studied, and ways for future optimization of treatment discussed.
Persistent Identifierhttp://hdl.handle.net/10722/213848
ISSN
2015 Impact Factor: 1.84
2015 SCImago Journal Rankings: 0.834

 

DC FieldValueLanguage
dc.contributor.authorLee, A. W M-
dc.contributor.authorLaw, S. C K-
dc.contributor.authorFoo, W.-
dc.contributor.authorPoon, Y. F.-
dc.contributor.authorChan, D. K K-
dc.contributor.authorO, SK-
dc.contributor.authorTung, S. Y.-
dc.contributor.authorCheung, F. K.-
dc.contributor.authorThaw, M.-
dc.contributor.authorHo, J. H C-
dc.date.accessioned2015-08-19T13:40:56Z-
dc.date.available2015-08-19T13:40:56Z-
dc.date.issued1993-
dc.identifier.citationBritish Journal of Radiology, 1993, v. 66, n. 786, p. 528-536-
dc.identifier.issn0007-1285-
dc.identifier.urihttp://hdl.handle.net/10722/213848-
dc.description.abstractThis is a retrospective analysis of the long-term local control in 4128 patients with non-disseminated nasopharyngeal carcinoma treated solely by megavoltage irradiation during the years 1976-1985. The T-stage distribution according to Ho's classification was T1 37%, T2 14% and T3 49%. Different fractionation schedules had been employed at different periods, and the median dose to the primary target was equivalent to 65 Gy by time dose fractionation calculation. In 8% (344) of patients the tumour failed to regress completely after the basic course, but 89% (148/167) of those suitable for salvage with additional irradiation eventually attained complete local remission. The cumulative incidence of local failure was 24% (5% persistence, 19% recurrence). The 10-year actuarial local failure-free survival was 67%. While patients with T2 and T3a tumours achieved local control comparable to T1, those with T3c-d had the poorest control (with highest incidence of persistence and advanced recurrence). T-stage adjusted analyses suggested a significant trend of dose-response: the odds ratios for local failure were 1.16 and 1.86, respectively, when patients given 60-63 Gy and 55-59 Gy were compared with those given 64 Gy or above (p value = 0.0018). Patients treated during 1981-1985 achieved higher local failure-free survival than those treated during 1976-1980 (75% versus 70% at 5 years, p value = 0.0013). The possible attributes are studied, and ways for future optimization of treatment discussed.-
dc.languageeng-
dc.relation.ispartofBritish Journal of Radiology-
dc.titleNasopharyngeal carcinoma: Local control by megavoltage irradiation-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1259/0007-1285-66-786-528-
dc.identifier.pmid8330138-
dc.identifier.scopuseid_2-s2.0-0027175135-
dc.identifier.hkuros265787-
dc.identifier.volume66-
dc.identifier.issue786-
dc.identifier.spage528-
dc.identifier.epage536-

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