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Article: Treatment of stage I nasopharyngeal carcinoma: Analysis of the patterns of relapse and the results of withholding elective neck irradiation

TitleTreatment of stage I nasopharyngeal carcinoma: Analysis of the patterns of relapse and the results of withholding elective neck irradiation
Authors
KeywordsMegavoltage radiation therapy
Patterns of relapse
No elective whole neck irradiation
Nasopharyngeal carcinoma
Prognostic factors
Treatment complications
Stage I (Ho's classification)
Issue Date1989
Citation
International Journal of Radiation Oncology - Biology - Physics, 1989, v. 17, n. 6, p. 1183-1190 How to Cite?
AbstractThis is a retrospective analysis of 196 patients with nasopharyngeal carcinoma Stage I (Ho's classification) treated by megavoltage radiation during 1980-1984. The primary target volume included all potential sites of local invasion and the first station lymph nodes at retropharyngeal spaces. Two different dose schedules were used, both gave a total tumor dose biologically equivalent to 65 Gy by conventional fractionation, and both achieved a 5-year actuarial local-recurrence-free survival of 88%. Elective neck irradiation was withheld in all except seven patients. The overall 7-year actuarial survival was 85%, but the relapse-free survival was only 62%. The patterns of relapse, prognostic factors, and treatment complications were analyzed. Eighteen patients (9%) recurred locally. Radical retreatment with radiation achieved complete remission in seven out of fifteen cases. Distant failure occurred in 17 patients (9%). Although 57 (30%) of the 189 patients without elective neck irradiation subsequently showed lymph node involvement, none of the seven regionally-treated patients relapsed. The successful regional salvage rate was 81% overall (46 out of 57 patients), but 90% (44 of 49) for those properly treated with whole neck irradiation. However, the 7-year actuarial survival was lower in patients with nodal relapse than those without (70% versus 87%) because of the associated higher incidence of hematogenous dissemination. The various aspects of treatment, the value of elective neck irradiation in particular, are discussed. © 1989.
Persistent Identifierhttp://hdl.handle.net/10722/213842
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274

 

DC FieldValueLanguage
dc.contributor.authorLee, Anne W M-
dc.contributor.authorSham, Jonathan S T-
dc.contributor.authorPoon, Y. F.-
dc.contributor.authorHo, John H C-
dc.date.accessioned2015-08-19T13:40:55Z-
dc.date.available2015-08-19T13:40:55Z-
dc.date.issued1989-
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 1989, v. 17, n. 6, p. 1183-1190-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/213842-
dc.description.abstractThis is a retrospective analysis of 196 patients with nasopharyngeal carcinoma Stage I (Ho's classification) treated by megavoltage radiation during 1980-1984. The primary target volume included all potential sites of local invasion and the first station lymph nodes at retropharyngeal spaces. Two different dose schedules were used, both gave a total tumor dose biologically equivalent to 65 Gy by conventional fractionation, and both achieved a 5-year actuarial local-recurrence-free survival of 88%. Elective neck irradiation was withheld in all except seven patients. The overall 7-year actuarial survival was 85%, but the relapse-free survival was only 62%. The patterns of relapse, prognostic factors, and treatment complications were analyzed. Eighteen patients (9%) recurred locally. Radical retreatment with radiation achieved complete remission in seven out of fifteen cases. Distant failure occurred in 17 patients (9%). Although 57 (30%) of the 189 patients without elective neck irradiation subsequently showed lymph node involvement, none of the seven regionally-treated patients relapsed. The successful regional salvage rate was 81% overall (46 out of 57 patients), but 90% (44 of 49) for those properly treated with whole neck irradiation. However, the 7-year actuarial survival was lower in patients with nodal relapse than those without (70% versus 87%) because of the associated higher incidence of hematogenous dissemination. The various aspects of treatment, the value of elective neck irradiation in particular, are discussed. © 1989.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physics-
dc.subjectMegavoltage radiation therapy-
dc.subjectPatterns of relapse-
dc.subjectNo elective whole neck irradiation-
dc.subjectNasopharyngeal carcinoma-
dc.subjectPrognostic factors-
dc.subjectTreatment complications-
dc.subjectStage I (Ho's classification)-
dc.titleTreatment of stage I nasopharyngeal carcinoma: Analysis of the patterns of relapse and the results of withholding elective neck irradiation-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0360-3016(89)90524-5-
dc.identifier.pmid2513290-
dc.identifier.scopuseid_2-s2.0-0024816501-
dc.identifier.hkuros265776-
dc.identifier.volume17-
dc.identifier.issue6-
dc.identifier.spage1183-
dc.identifier.epage1190-

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