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Conference Paper: The spread of minority HIV-1 strains in Hong Kong
Title | The spread of minority HIV-1 strains in Hong Kong |
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Authors | |
Issue Date | 2013 |
Citation | The 18th International Bioinformatics Workshop on Virus Evolution and Molecular Epidemiology (VEME), Gainesville, FL., 25-30 August 2013. How to Cite? |
Abstract | In the last decade, various molecular assays and sequencing techniques have vulgarized the HIV-1 epidemiological and phylogenetic study across the major continents. HIV-1 group M is divided into many subtypes, and dominates in different parts of the world. Being one of the busiest harbor ports, Hong Kong has a mosaic genetic diversity. During the period of 2000 – 2012, both subtypes B and CRF01_AE had accounted for about 80% of HIV-1 infection in Hong Kong. This study aimed to investigate the remaining 20% of the minority HIV-1 strains in our region. A total of 1995 HIV-1 infected patients, who sought medical consultation at the Government Integrated Treatment Centre during 2000 – 2012, were included in this study. HIV-1 pol genes were sequenced by our in-house genotyping assay and preliminary subtyped by REGA. The minority strains included 4.4% subtype C, 3.2% CRF07_BC, 1.1% CRF02_AG, 0.9% subtype A1, 0.7% CRF08_BC, and <1% subtype G, D, CRF06_cpx and CRF12_BF. Phylogenetic analysis revealed 4 different groups in subtype C, that were transmitted through heterosexual African, heterosexual non-Chinese Asian, heterosexual Chinese and needle-sharing non-Chinese Asian. Two major clusters from homosexual Chinese and needle-sharing Chinese were also observed in CRF07_BC. The number of cases was limited in other minor subtypes and no clusters were observed. Due to huge volume of tourism from China, subtype C and CRF07_BC were suspected to have been imported through the borders. Closer monitoring is required on these minorities to prevent establishment and larger spread in the future. |
Persistent Identifier | http://hdl.handle.net/10722/213804 |
DC Field | Value | Language |
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dc.contributor.author | To, WCS | - |
dc.contributor.author | Chen, JHK | - |
dc.contributor.author | Yam, WC | - |
dc.date.accessioned | 2015-08-18T07:54:36Z | - |
dc.date.available | 2015-08-18T07:54:36Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | The 18th International Bioinformatics Workshop on Virus Evolution and Molecular Epidemiology (VEME), Gainesville, FL., 25-30 August 2013. | - |
dc.identifier.uri | http://hdl.handle.net/10722/213804 | - |
dc.description.abstract | In the last decade, various molecular assays and sequencing techniques have vulgarized the HIV-1 epidemiological and phylogenetic study across the major continents. HIV-1 group M is divided into many subtypes, and dominates in different parts of the world. Being one of the busiest harbor ports, Hong Kong has a mosaic genetic diversity. During the period of 2000 – 2012, both subtypes B and CRF01_AE had accounted for about 80% of HIV-1 infection in Hong Kong. This study aimed to investigate the remaining 20% of the minority HIV-1 strains in our region. A total of 1995 HIV-1 infected patients, who sought medical consultation at the Government Integrated Treatment Centre during 2000 – 2012, were included in this study. HIV-1 pol genes were sequenced by our in-house genotyping assay and preliminary subtyped by REGA. The minority strains included 4.4% subtype C, 3.2% CRF07_BC, 1.1% CRF02_AG, 0.9% subtype A1, 0.7% CRF08_BC, and <1% subtype G, D, CRF06_cpx and CRF12_BF. Phylogenetic analysis revealed 4 different groups in subtype C, that were transmitted through heterosexual African, heterosexual non-Chinese Asian, heterosexual Chinese and needle-sharing non-Chinese Asian. Two major clusters from homosexual Chinese and needle-sharing Chinese were also observed in CRF07_BC. The number of cases was limited in other minor subtypes and no clusters were observed. Due to huge volume of tourism from China, subtype C and CRF07_BC were suspected to have been imported through the borders. Closer monitoring is required on these minorities to prevent establishment and larger spread in the future. | - |
dc.language | eng | - |
dc.relation.ispartof | International Bioinformatics Workshop on Virus Evolution and Molecular Epidemiology, VEME 2013 | - |
dc.title | The spread of minority HIV-1 strains in Hong Kong | - |
dc.type | Conference_Paper | - |
dc.identifier.email | To, WCS: towaichi@hku.hk | - |
dc.identifier.email | Chen, JHK: jonchk@hku.hk | - |
dc.identifier.email | Yam, WC: wcyam@hkucc.hku.hk | - |
dc.identifier.authority | Yam, WC=rp00313 | - |
dc.identifier.hkuros | 246535 | - |