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Conference Paper: The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) regulates the chemo-sensitivity of liver cancer cells
Title | The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) regulates the chemo-sensitivity of liver cancer cells |
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Authors | |
Issue Date | 2015 |
Publisher | WIN 2015 Symposium. |
Citation | The 7th WIN Symposium, Paris, France, 29-30 June 2015. How to Cite? |
Abstract | BACKGROUND: The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) was first identified as a cellular interacting partner of HTLV-I virus oncoprotein, TAX1. Further investigation has shown that TAX1BP2 was targeted by TAX1 to induce supernumerary centrosome in TAX1-expressing cells. Recently, TAX1BP2 was found to be frequently underexpressed in hepatocellular carcinoma (HCC) and underexpression of TAX1BP2 suppressed the activation of tumor suppressor p53 in a p38 MAPK dependent manner, suggesting that TAX1BP2 is a putative tumor suppressor in HCC. Here we provide ... |
Description | Poster Session 6 - New Drug Targets: no. P6.04 |
Persistent Identifier | http://hdl.handle.net/10722/213792 |
DC Field | Value | Language |
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dc.contributor.author | Ching, YP | - |
dc.contributor.author | Lai, WL | - |
dc.date.accessioned | 2015-08-18T04:56:37Z | - |
dc.date.available | 2015-08-18T04:56:37Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The 7th WIN Symposium, Paris, France, 29-30 June 2015. | - |
dc.identifier.uri | http://hdl.handle.net/10722/213792 | - |
dc.description | Poster Session 6 - New Drug Targets: no. P6.04 | - |
dc.description.abstract | BACKGROUND: The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) was first identified as a cellular interacting partner of HTLV-I virus oncoprotein, TAX1. Further investigation has shown that TAX1BP2 was targeted by TAX1 to induce supernumerary centrosome in TAX1-expressing cells. Recently, TAX1BP2 was found to be frequently underexpressed in hepatocellular carcinoma (HCC) and underexpression of TAX1BP2 suppressed the activation of tumor suppressor p53 in a p38 MAPK dependent manner, suggesting that TAX1BP2 is a putative tumor suppressor in HCC. Here we provide ... | - |
dc.language | eng | - |
dc.publisher | WIN 2015 Symposium. | - |
dc.relation.ispartof | 7th WIN Symposium | - |
dc.title | The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) regulates the chemo-sensitivity of liver cancer cells | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Ching, YP: ypching@hku.hk | - |
dc.identifier.email | Lai, WL: bennywll@hku.hk | - |
dc.identifier.authority | Ching, YP=rp00469 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.hkuros | 246435 | - |
dc.publisher.place | France | - |