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Article: Increase in the nasopharyngeal carriage of non-vaccine serogroup 15 Streptococcus pneumoniae after introduction of children pneumococcal conjugate vaccination in Hong Kong

TitleIncrease in the nasopharyngeal carriage of non-vaccine serogroup 15 Streptococcus pneumoniae after introduction of children pneumococcal conjugate vaccination in Hong Kong
Authors
Issue Date2015
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
Citation
Diagnostic Microbiology and Infectious Disease, 2015, v. 81 n. 2, p. 145-148 How to Cite?
AbstractThis study assessed pneumococcal carriage in the early periods after routine use of 13-valent pneumococcal conjugate vaccine (PCV13) in Hong Kong. Nasopharyngeal swabs were obtained from 1110 children (<5 years) admitted with acute illness during September 2010–August 2013. Pneumococcal carriage rate was 13.5% in unvaccinated children, 14.1% in children who had ≥1 PCV dose and 15.3% in children who had ≥3 PCV doses. Nonv-PCV13 serotypes comprised 56.4% of all isolates. The most common serogroup/types were 15 (15A, 5.1%; 15B, 10.3%; 15C, 9.6%; 15F, 0.6%), 19F (17.9%), 6A (7.1%) and 6C (7.1%). Carriage of serogroup 15 was more common among vaccinated children (4.1% versus 0.6%, P = 0.033). Molecular typing revealed that expansion of several clones (clonal complex, CC63, CC199, CC1262, CC3397) was responsible for the increase in serogroup 15. Almost all CC63 and CC3397 isolates were nonsusceptible to both penicillin and erythromycin. The finding highlights the emergence of serogroup 15 following PCV13 use.
Persistent Identifierhttp://hdl.handle.net/10722/213732
ISSN
2015 Impact Factor: 2.45
2015 SCImago Journal Rankings: 1.142
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, PL-
dc.contributor.authorChiu, SSS-
dc.contributor.authorLaw, PYT-
dc.contributor.authorChan, ELY-
dc.contributor.authorLai, ELY-
dc.contributor.authorChow, KH-
dc.date.accessioned2015-08-14T03:54:46Z-
dc.date.available2015-08-14T03:54:46Z-
dc.date.issued2015-
dc.identifier.citationDiagnostic Microbiology and Infectious Disease, 2015, v. 81 n. 2, p. 145-148-
dc.identifier.issn0732-8893-
dc.identifier.urihttp://hdl.handle.net/10722/213732-
dc.description.abstractThis study assessed pneumococcal carriage in the early periods after routine use of 13-valent pneumococcal conjugate vaccine (PCV13) in Hong Kong. Nasopharyngeal swabs were obtained from 1110 children (<5 years) admitted with acute illness during September 2010–August 2013. Pneumococcal carriage rate was 13.5% in unvaccinated children, 14.1% in children who had ≥1 PCV dose and 15.3% in children who had ≥3 PCV doses. Nonv-PCV13 serotypes comprised 56.4% of all isolates. The most common serogroup/types were 15 (15A, 5.1%; 15B, 10.3%; 15C, 9.6%; 15F, 0.6%), 19F (17.9%), 6A (7.1%) and 6C (7.1%). Carriage of serogroup 15 was more common among vaccinated children (4.1% versus 0.6%, P = 0.033). Molecular typing revealed that expansion of several clones (clonal complex, CC63, CC199, CC1262, CC3397) was responsible for the increase in serogroup 15. Almost all CC63 and CC3397 isolates were nonsusceptible to both penicillin and erythromycin. The finding highlights the emergence of serogroup 15 following PCV13 use.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio-
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease-
dc.rights© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleIncrease in the nasopharyngeal carriage of non-vaccine serogroup 15 Streptococcus pneumoniae after introduction of children pneumococcal conjugate vaccination in Hong Kong-
dc.typeArticle-
dc.identifier.emailHo, PL: plho@hkucc.hku.hk-
dc.identifier.emailChiu, SSS: ssschiu@hku.hk-
dc.identifier.emailChan, ELY: laiyin@hkucc.hku.hk-
dc.identifier.emailLai, ELY: elylai@hku.hk-
dc.identifier.emailChow, KH: khchowb@hku.hk-
dc.identifier.authorityHo, PL=rp00406-
dc.identifier.authorityChiu, SSS=rp00421-
dc.identifier.authorityChow, KH=rp00370-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.diagmicrobio.2014.11.006-
dc.identifier.pmid25483278-
dc.identifier.scopuseid_2-s2.0-84922333949-
dc.identifier.hkuros246372-
dc.identifier.volume81-
dc.identifier.issue2-
dc.identifier.spage145-
dc.identifier.epage148-
dc.identifier.isiWOS:000348491500016-
dc.publisher.placeUnited States-

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