File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)

Conference Paper: The association between oral fluoroquinolones and incident seizure event

TitleThe association between oral fluoroquinolones and incident seizure event
Authors
KeywordsPharmacy and pharmacology
Issue Date2014
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/5669
Citation
The 30th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE Conference), Taipei, Taiwan, 24-27 October 2014. In Pharmacoepidemiology and Drug Safety, 2014, v. 23 n. S1, p. 440, abstract 820 How to Cite?
AbstractBACKGROUND: Fluoroquinolones are a class of antibiotics prescribed for various infections. Several case reports have indicated the potential association between the use of oral fluoroquinolones and the development of incident seizure event. OBJECTIVES: The objectives of this study were to: 1) investigate the association between the use of oral fluoroquinolones and the development of incident seizure event; 2) to estimate the crude absolute risk of developing incident seizure event whilst prescribed with oral fluoroquinolones. METHODS: A self-controlled case series study design was used to investigate the association. Patients were retrieved from an electronic patient record database called the Clinical Data Analysis and Reporting System in Hong Kong from the year of 2001 to 2013. Patients who had an incident seizure event and were prescribed with oral fluoroquinolones in the out-patients setting during the study period were included. Those with a history of post-traumatic or febrile convulsion were excluded. The rate of having incident seizure event during the exposure period was compared with the non-exposed period. Conditional Poisson regression was used to estimate the incidence rate ratio at a 5% significance level. A sensitivity analysis was conducted by excluding patients who died within 30 days after the incident seizure event. RESULTS: A total of 291,751 prescriptions of oral fluoroquinolones were identified among 166,325 patients. A total of 2,206 patients met the case definition and were included in the analysis. An incidence rate ratio of 0.89 (0.52, 1.53) was estimated. Fourteen cases of incident seizure event occurred during the exposure period. The crude absolute risk of having incident seizure event whilst prescribed with oral fluoroquinolones was approximately 4.8x10^-5 (2.9x10^-5, 8.1x10^-5). No statistically significant association was observed between the use of oral fluoroquinolones and the development of incident seizure event in the sensitivity analysis. CONCLUSIONS: This study does not support the association between the use of oral fluoroquinolones and the development of incident seizure event.
DescriptionPoster Session C - Spotlight Session - Asian Pharmacoepidemiology Network (AsPEN) SIG: no. 820
This journal suppl. entitled: Special Issue: Abstracts of the 30th International Conference on Pharmacoepidemiology and Therapeutic Risk Management ... 2014
Persistent Identifierhttp://hdl.handle.net/10722/213614
ISSN
2015 Impact Factor: 2.908
2015 SCImago Journal Rankings: 1.804

 

DC FieldValueLanguage
dc.contributor.authorChui, SLC-
dc.contributor.authorChan, EW-
dc.contributor.authorWong, ICK-
dc.date.accessioned2015-08-07T02:05:59Z-
dc.date.available2015-08-07T02:05:59Z-
dc.date.issued2014-
dc.identifier.citationThe 30th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE Conference), Taipei, Taiwan, 24-27 October 2014. In Pharmacoepidemiology and Drug Safety, 2014, v. 23 n. S1, p. 440, abstract 820-
dc.identifier.issn1053-8569-
dc.identifier.urihttp://hdl.handle.net/10722/213614-
dc.descriptionPoster Session C - Spotlight Session - Asian Pharmacoepidemiology Network (AsPEN) SIG: no. 820-
dc.descriptionThis journal suppl. entitled: Special Issue: Abstracts of the 30th International Conference on Pharmacoepidemiology and Therapeutic Risk Management ... 2014-
dc.description.abstractBACKGROUND: Fluoroquinolones are a class of antibiotics prescribed for various infections. Several case reports have indicated the potential association between the use of oral fluoroquinolones and the development of incident seizure event. OBJECTIVES: The objectives of this study were to: 1) investigate the association between the use of oral fluoroquinolones and the development of incident seizure event; 2) to estimate the crude absolute risk of developing incident seizure event whilst prescribed with oral fluoroquinolones. METHODS: A self-controlled case series study design was used to investigate the association. Patients were retrieved from an electronic patient record database called the Clinical Data Analysis and Reporting System in Hong Kong from the year of 2001 to 2013. Patients who had an incident seizure event and were prescribed with oral fluoroquinolones in the out-patients setting during the study period were included. Those with a history of post-traumatic or febrile convulsion were excluded. The rate of having incident seizure event during the exposure period was compared with the non-exposed period. Conditional Poisson regression was used to estimate the incidence rate ratio at a 5% significance level. A sensitivity analysis was conducted by excluding patients who died within 30 days after the incident seizure event. RESULTS: A total of 291,751 prescriptions of oral fluoroquinolones were identified among 166,325 patients. A total of 2,206 patients met the case definition and were included in the analysis. An incidence rate ratio of 0.89 (0.52, 1.53) was estimated. Fourteen cases of incident seizure event occurred during the exposure period. The crude absolute risk of having incident seizure event whilst prescribed with oral fluoroquinolones was approximately 4.8x10^-5 (2.9x10^-5, 8.1x10^-5). No statistically significant association was observed between the use of oral fluoroquinolones and the development of incident seizure event in the sensitivity analysis. CONCLUSIONS: This study does not support the association between the use of oral fluoroquinolones and the development of incident seizure event.-
dc.languageeng-
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/5669-
dc.relation.ispartofPharmacoepidemiology and Drug Safety-
dc.rightsPharmacoepidemiology and Drug Safety. Copyright © John Wiley & Sons Ltd.-
dc.subjectPharmacy and pharmacology-
dc.titleThe association between oral fluoroquinolones and incident seizure event-
dc.typeConference_Paper-
dc.identifier.emailChan, EW: ewchan@hku.hk-
dc.identifier.emailWong, ICK: wongick@HKUCC-COM.hku.hk-
dc.identifier.authorityChan, EW=rp01587-
dc.identifier.authorityWong, ICK=rp01480-
dc.identifier.doi10.1002/pds.3701-
dc.identifier.hkuros246073-
dc.identifier.volume23-
dc.identifier.issueS1-
dc.identifier.spage440, abstract 820-
dc.identifier.epage440, abstract 820-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats