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Article: The CEPHEUS Pan-Asian survey: High low-density lipoprotein cholesterol goal attainment rate among hypercholesterolaemic patients undergoing lipid-lowering treatment in a Hong Kong regional centre

TitleThe CEPHEUS Pan-Asian survey: High low-density lipoprotein cholesterol goal attainment rate among hypercholesterolaemic patients undergoing lipid-lowering treatment in a Hong Kong regional centre
Authors
KeywordsTreatment outcome
Cholesterol, LDL
Anticholesteremic agents
Cardiovascular diseases/prevention and control
Hypercholesterolemia
Issue Date2012
Citation
Hong Kong Medical Journal, 2012, v. 18, n. 5, p. 395-406 How to Cite?
AbstractObjectives To evaluate attainment of low-density lipoprotein cholesterol goals among hypercholesterolaemic patients undergoing lipidlowering drug treatment in Hong Kong and to identify potential determinants of treatment outcomes. Design Cross-sectional observational study. Setting A single site in Hong Kong, as part of the CEPHEUS Pan-Asian survey. Patients Subjects with hypercholesterolaemia aged 18 years or above, who had been on lipid-lowering drug treatment for at least 3 months with no dose adjustment for at least 6 weeks. Results A total of 561 such patients (mean age, 65.3; standard deviation, 9.7 years) were evaluated. Most had major cardiovascular risk factors; 534 (95.2%) of 561 patients had coronary heart disease and 534 (95.4%) of 560 patients had low-density lipoprotein cholesterol goals set at lower than 70 mg/dL. In all, 465 (82.9%) patients attained their respective low-density lipoprotein cholesterol goals. Among 75 patients who had coronary heart disease or equivalent risk, and multiple risk factors with a 10-year coronary heart disease risk of over 20%, 62 (82.7%) attained their respective low-density lipoprotein cholesterol goals. Significant predictors of low-density lipoprotein cholesterol goal attainment included the patient's baseline lipid profile (total cholesterol and low-density lipoprotein cholesterol levels), blood pressure, and drugs (statin/non-statin) used for treatment. Conclusions Hypercholesterolaemic patients undergoing lipid-lowering drug treatment in the present Hong Kong study were able to achieve a very high attainment rate for the low-density lipoprotein cholesterol goal, despite the fact that most of them had major cardiovascular risk factors.
Persistent Identifierhttp://hdl.handle.net/10722/213281
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChan, Raymond H W-
dc.contributor.authorChan, P. H.-
dc.contributor.authorChan, Kelvin K W-
dc.contributor.authorLam, Simon C C-
dc.contributor.authorHai, Jo Jo-
dc.contributor.authorWong, Michael K L-
dc.contributor.authorTam, Frankie C C-
dc.contributor.authorLam, Linda-
dc.contributor.authorChan, Carmen W S-
dc.contributor.authorLam, Y. M.-
dc.contributor.authorSiu, David C W-
dc.contributor.authorTse, H. F.-
dc.contributor.authorLee, Stephen W L-
dc.date.accessioned2015-07-28T04:06:46Z-
dc.date.available2015-07-28T04:06:46Z-
dc.date.issued2012-
dc.identifier.citationHong Kong Medical Journal, 2012, v. 18, n. 5, p. 395-406-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/213281-
dc.description.abstractObjectives To evaluate attainment of low-density lipoprotein cholesterol goals among hypercholesterolaemic patients undergoing lipidlowering drug treatment in Hong Kong and to identify potential determinants of treatment outcomes. Design Cross-sectional observational study. Setting A single site in Hong Kong, as part of the CEPHEUS Pan-Asian survey. Patients Subjects with hypercholesterolaemia aged 18 years or above, who had been on lipid-lowering drug treatment for at least 3 months with no dose adjustment for at least 6 weeks. Results A total of 561 such patients (mean age, 65.3; standard deviation, 9.7 years) were evaluated. Most had major cardiovascular risk factors; 534 (95.2%) of 561 patients had coronary heart disease and 534 (95.4%) of 560 patients had low-density lipoprotein cholesterol goals set at lower than 70 mg/dL. In all, 465 (82.9%) patients attained their respective low-density lipoprotein cholesterol goals. Among 75 patients who had coronary heart disease or equivalent risk, and multiple risk factors with a 10-year coronary heart disease risk of over 20%, 62 (82.7%) attained their respective low-density lipoprotein cholesterol goals. Significant predictors of low-density lipoprotein cholesterol goal attainment included the patient's baseline lipid profile (total cholesterol and low-density lipoprotein cholesterol levels), blood pressure, and drugs (statin/non-statin) used for treatment. Conclusions Hypercholesterolaemic patients undergoing lipid-lowering drug treatment in the present Hong Kong study were able to achieve a very high attainment rate for the low-density lipoprotein cholesterol goal, despite the fact that most of them had major cardiovascular risk factors.-
dc.languageeng-
dc.relation.ispartofHong Kong Medical Journal-
dc.subjectTreatment outcome-
dc.subjectCholesterol, LDL-
dc.subjectAnticholesteremic agents-
dc.subjectCardiovascular diseases/prevention and control-
dc.subjectHypercholesterolemia-
dc.titleThe CEPHEUS Pan-Asian survey: High low-density lipoprotein cholesterol goal attainment rate among hypercholesterolaemic patients undergoing lipid-lowering treatment in a Hong Kong regional centre-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.pmid23018067-
dc.identifier.scopuseid_2-s2.0-84870941954-
dc.identifier.volume18-
dc.identifier.issue5-
dc.identifier.spage395-
dc.identifier.epage406-

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