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Article: A high-speed automatic system for measuring the mechanical properties of cells

TitleA high-speed automatic system for measuring the mechanical properties of cells
Authors
KeywordsAutomation
Local scan
Mechanical properties of cells
Atomic force microscopy (AFM)
Issue Date2012
Citation
Zidonghua Xuebao/Acta Automatica Sinica, 2012, v. 38, n. 10, p. 1639-1645 How to Cite?
AbstractAs a novel effective label-free biomarker, the mechanical properties of cells have become increasingly important. However, the current methods of mapping the cellular mechanical properties are mostly carried out manually and this results in that the measurements are time consuming, which can not meet the demand of testing a large quantity of cell samples for biological statistical analysis. In this paper, a high-speed automatic system for measuring the mechanical properties of cells based on atomic force microscopy (AFM) is proposed. In this system, cells are recognized using an image processing method and the relative position of the cell with respect to AFM tip is accurately calibrated by the local scan method, i.e., the mechanical properties of cells can be measured sequentially without performing the step of AFM imaging. Besides, with the automation implementation, the high-throughput measurement of cellular mechanical properties can be performed rapidly. Experimental results show that the measurement efficiency of our system is 27 times faster than that of the traditional method. Copyright © 2012 Acta Automatica Sinica. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/213272
ISSN
2015 SCImago Journal Rankings: 0.472

 

DC FieldValueLanguage
dc.contributor.authorWang, Zhi Bo-
dc.contributor.authorLiu, Lian Qing-
dc.contributor.authorWang, Yue Chao-
dc.contributor.authorXi, Ning-
dc.contributor.authorDong, Zai Li-
dc.contributor.authorHuang, Shu Tao-
dc.date.accessioned2015-07-28T04:06:44Z-
dc.date.available2015-07-28T04:06:44Z-
dc.date.issued2012-
dc.identifier.citationZidonghua Xuebao/Acta Automatica Sinica, 2012, v. 38, n. 10, p. 1639-1645-
dc.identifier.issn0254-4156-
dc.identifier.urihttp://hdl.handle.net/10722/213272-
dc.description.abstractAs a novel effective label-free biomarker, the mechanical properties of cells have become increasingly important. However, the current methods of mapping the cellular mechanical properties are mostly carried out manually and this results in that the measurements are time consuming, which can not meet the demand of testing a large quantity of cell samples for biological statistical analysis. In this paper, a high-speed automatic system for measuring the mechanical properties of cells based on atomic force microscopy (AFM) is proposed. In this system, cells are recognized using an image processing method and the relative position of the cell with respect to AFM tip is accurately calibrated by the local scan method, i.e., the mechanical properties of cells can be measured sequentially without performing the step of AFM imaging. Besides, with the automation implementation, the high-throughput measurement of cellular mechanical properties can be performed rapidly. Experimental results show that the measurement efficiency of our system is 27 times faster than that of the traditional method. Copyright © 2012 Acta Automatica Sinica. All rights reserved.-
dc.languageeng-
dc.relation.ispartofZidonghua Xuebao/Acta Automatica Sinica-
dc.subjectAutomation-
dc.subjectLocal scan-
dc.subjectMechanical properties of cells-
dc.subjectAtomic force microscopy (AFM)-
dc.titleA high-speed automatic system for measuring the mechanical properties of cells-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.3724/SP.J.1004.2012.01639-
dc.identifier.scopuseid_2-s2.0-84869147559-
dc.identifier.volume38-
dc.identifier.issue10-
dc.identifier.spage1639-
dc.identifier.epage1645-

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