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Article: Imaging and measuring the rituximab-induced changes of mechanical properties in B-lymphoma cells using atomic force microscopy

TitleImaging and measuring the rituximab-induced changes of mechanical properties in B-lymphoma cells using atomic force microscopy
Authors
KeywordsAtomic force microscopy
Young's modulus
Rituximab
Mechanical properties
Issue Date2011
Citation
Biochemical and Biophysical Research Communications, 2011, v. 404, n. 2, p. 689-694 How to Cite?
AbstractThe topography and mechanical properties of single B-lymphoma cells have been investigated by atomic force microscopy (AFM). With the assistance of microfabricated patterned pillars, the surface topography and ultrastructure of single living B-lymphoma cell were visualized by AFM. The apoptosis of B-lymphoma cells induced by rituximab alone was observed by acridine orange/ethidium bromide (AO/EB) double fluorescent staining. The rituximab-induced changes of mechanical properties in B-lymphoma cells were measured dynamically and the results showed that B-lymphoma cells became dramatically softer after incubation with rituximab. These results can improve our understanding of rituximab'effect and will facilitate the further investigation of the underlying mechanisms. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/213134
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152

 

DC FieldValueLanguage
dc.contributor.authorLi, Mi-
dc.contributor.authorLiu, Lianqing-
dc.contributor.authorXi, Ning-
dc.contributor.authorWang, Yuechao-
dc.contributor.authorDong, Zaili-
dc.contributor.authorTabata, Osamu-
dc.contributor.authorXiao, Xiubin-
dc.contributor.authorZhang, Weijing-
dc.date.accessioned2015-07-28T04:06:14Z-
dc.date.available2015-07-28T04:06:14Z-
dc.date.issued2011-
dc.identifier.citationBiochemical and Biophysical Research Communications, 2011, v. 404, n. 2, p. 689-694-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10722/213134-
dc.description.abstractThe topography and mechanical properties of single B-lymphoma cells have been investigated by atomic force microscopy (AFM). With the assistance of microfabricated patterned pillars, the surface topography and ultrastructure of single living B-lymphoma cell were visualized by AFM. The apoptosis of B-lymphoma cells induced by rituximab alone was observed by acridine orange/ethidium bromide (AO/EB) double fluorescent staining. The rituximab-induced changes of mechanical properties in B-lymphoma cells were measured dynamically and the results showed that B-lymphoma cells became dramatically softer after incubation with rituximab. These results can improve our understanding of rituximab'effect and will facilitate the further investigation of the underlying mechanisms. © 2010 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofBiochemical and Biophysical Research Communications-
dc.subjectAtomic force microscopy-
dc.subjectYoung's modulus-
dc.subjectRituximab-
dc.subjectMechanical properties-
dc.titleImaging and measuring the rituximab-induced changes of mechanical properties in B-lymphoma cells using atomic force microscopy-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2010.12.043-
dc.identifier.pmid21156157-
dc.identifier.scopuseid_2-s2.0-78651367788-
dc.identifier.volume404-
dc.identifier.issue2-
dc.identifier.spage689-
dc.identifier.epage694-
dc.identifier.eissn1090-2104-

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