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Article: Nanotechnology and Membrane Receptors: Focus on Angiotensin II Receptors

TitleNanotechnology and Membrane Receptors: Focus on Angiotensin II Receptors
Authors
Issue Date2007
Citation
Medical Clinics of North America, 2007, v. 91, n. 5, p. 929-936 How to Cite?
AbstractThe use of a functionalized tip to measure the force of the interaction between ligands and receptors by atomic force microscopy has been discussed for more than a decade, and single-molecule recognition using a functionalized tip from processed samples is achievable now. Techniques for detecting and characterizing specific individual molecules from a living cell are still developing and are discussed in this article. Because many diseases have their roots at the molecular scale and are best understood as a malfunctioning of biologic nanomachines, these techniques should find widespread use in basic biomedical research once the remaining barriers are overcome. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/212940
ISSN
2015 Impact Factor: 2.333
2015 SCImago Journal Rankings: 0.796

 

DC FieldValueLanguage
dc.contributor.authorLi, Guangyong-
dc.contributor.authorXi, Ning-
dc.contributor.authorWang, Donna H.-
dc.date.accessioned2015-07-28T04:05:31Z-
dc.date.available2015-07-28T04:05:31Z-
dc.date.issued2007-
dc.identifier.citationMedical Clinics of North America, 2007, v. 91, n. 5, p. 929-936-
dc.identifier.issn0025-7125-
dc.identifier.urihttp://hdl.handle.net/10722/212940-
dc.description.abstractThe use of a functionalized tip to measure the force of the interaction between ligands and receptors by atomic force microscopy has been discussed for more than a decade, and single-molecule recognition using a functionalized tip from processed samples is achievable now. Techniques for detecting and characterizing specific individual molecules from a living cell are still developing and are discussed in this article. Because many diseases have their roots at the molecular scale and are best understood as a malfunctioning of biologic nanomachines, these techniques should find widespread use in basic biomedical research once the remaining barriers are overcome. © 2007 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofMedical Clinics of North America-
dc.titleNanotechnology and Membrane Receptors: Focus on Angiotensin II Receptors-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.mcna.2007.05.003-
dc.identifier.pmid17826111-
dc.identifier.scopuseid_2-s2.0-34548448040-
dc.identifier.volume91-
dc.identifier.issue5-
dc.identifier.spage929-
dc.identifier.epage936-

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