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Article: The Correlation of Retinal Nerve Fiber Layer Thickness With Blood Pressure in a Chinese Hypertensive Population

TitleThe Correlation of Retinal Nerve Fiber Layer Thickness With Blood Pressure in a Chinese Hypertensive Population
Authors
Issue Date2015
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.md-journal.com
Citation
Medicine (Baltimore): analytical reviews of general medicine, neurology, psychiatry, dermatology and pediatrics, 2015, v. 94 n. 23, p. e947 How to Cite?
AbstractTo investigate the association between retinal nerve fiber layer (RNFL) thickness and blood pressure (BP) in subjects with systemic hypertension. Subjects with systemic hypertension on anti-hypertensive medications were screened by fundus photography and referred for glaucoma work-up if there was enlarged vertical cup-to-disc (VCDR) ratio ≥0.6, VCDR asymmetry ≥0.2, or optic disc hemorrhage. Workup included a complete ophthalmological examination, Humphrey visual field test, and RNFL thickness measurement by optical coherence tomography. The intraocular pressure (IOP) and RNFL thicknesses (global and quadrant) were averaged from both eyes and the means were correlated with: the systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP) using Pearson correlation. Among 4000 screened hypertensive subjects, 133 were referred for glaucoma workup and 110 completed the workup. Of the 4000 screened subjects, 1.3% had glaucoma (0.9% had normal tension glaucoma [NTG], 0.2% had primary open angle glaucoma, and 0.2% had primary angle closure glaucoma), whereas 0.3% were NTG suspects. The SBP was negatively correlated with the mean superior RNFL thickness (P=0.01). The DBP was negatively correlated with the mean global (P=0.03), superior (P=0.02), and nasal (P=0.003) RNFL thickness. The MAP was negatively correlated with the mean global (P=0.01), superior (P=0.002), and nasal (P=0.004) RNFL thickness while positively correlated with the mean IOP (P=0.02). In medically treated hypertensive subjects, glaucoma was present in 1.3%, with NTG being most prevalent. MAP control may help with IOP lowering and RNFL preservation, although future prospective studies will be needed. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/212538
ISSN
2015 Impact Factor: 1.206
2015 SCImago Journal Rankings: 0.877
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGangwani, RA-
dc.contributor.authorLee, JWY-
dc.contributor.authorMo, HY-
dc.contributor.authorSum, R-
dc.contributor.authorKwong, ASK-
dc.contributor.authorWang, JHL-
dc.contributor.authorTsui, WWS-
dc.contributor.authorChan, JCH-
dc.contributor.authorLai, JSM-
dc.date.accessioned2015-07-21T02:39:55Z-
dc.date.available2015-07-21T02:39:55Z-
dc.date.issued2015-
dc.identifier.citationMedicine (Baltimore): analytical reviews of general medicine, neurology, psychiatry, dermatology and pediatrics, 2015, v. 94 n. 23, p. e947-
dc.identifier.issn0025-7974-
dc.identifier.urihttp://hdl.handle.net/10722/212538-
dc.description.abstractTo investigate the association between retinal nerve fiber layer (RNFL) thickness and blood pressure (BP) in subjects with systemic hypertension. Subjects with systemic hypertension on anti-hypertensive medications were screened by fundus photography and referred for glaucoma work-up if there was enlarged vertical cup-to-disc (VCDR) ratio ≥0.6, VCDR asymmetry ≥0.2, or optic disc hemorrhage. Workup included a complete ophthalmological examination, Humphrey visual field test, and RNFL thickness measurement by optical coherence tomography. The intraocular pressure (IOP) and RNFL thicknesses (global and quadrant) were averaged from both eyes and the means were correlated with: the systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP) using Pearson correlation. Among 4000 screened hypertensive subjects, 133 were referred for glaucoma workup and 110 completed the workup. Of the 4000 screened subjects, 1.3% had glaucoma (0.9% had normal tension glaucoma [NTG], 0.2% had primary open angle glaucoma, and 0.2% had primary angle closure glaucoma), whereas 0.3% were NTG suspects. The SBP was negatively correlated with the mean superior RNFL thickness (P=0.01). The DBP was negatively correlated with the mean global (P=0.03), superior (P=0.02), and nasal (P=0.003) RNFL thickness. The MAP was negatively correlated with the mean global (P=0.01), superior (P=0.002), and nasal (P=0.004) RNFL thickness while positively correlated with the mean IOP (P=0.02). In medically treated hypertensive subjects, glaucoma was present in 1.3%, with NTG being most prevalent. MAP control may help with IOP lowering and RNFL preservation, although future prospective studies will be needed. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.-
dc.languageeng-
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.md-journal.com-
dc.relation.ispartofMedicine (Baltimore): analytical reviews of general medicine, neurology, psychiatry, dermatology and pediatrics-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleThe Correlation of Retinal Nerve Fiber Layer Thickness With Blood Pressure in a Chinese Hypertensive Population-
dc.typeArticle-
dc.identifier.emailGangwani, RA: gangwani@hku.hk-
dc.identifier.emailLee, JWY: jackylee@hku.hk-
dc.identifier.emailChan, JCH: jonochan@hkucc.hku.hk-
dc.identifier.emailLai, JSM: laism@hku.hk-
dc.identifier.authorityGangwani, RA=rp01883-
dc.identifier.authorityLee, JWY=rp01498-
dc.identifier.authorityLai, JSM=rp00295-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1097/MD.0000000000000947-
dc.identifier.pmid26061324-
dc.identifier.scopuseid_2-s2.0-84940025334-
dc.identifier.hkuros244320-
dc.identifier.hkuros264619-
dc.identifier.volume94-
dc.identifier.issue23-
dc.identifier.spagee947-
dc.identifier.epagee947-
dc.identifier.isiWOS:000360718400001-
dc.publisher.placeUnited States-

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