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Article: Polysaccharides of Dendrobium officinale Induce Aquaporin 5 Translocation by Activating M3 Muscarinic Receptors

TitlePolysaccharides of Dendrobium officinale Induce Aquaporin 5 Translocation by Activating M3 Muscarinic Receptors
Authors
Issue Date2015
Citation
Planta Medica, 2015, v. 81 n. 2, p. 130-137 How to Cite?
AbstractDendrobium officinale is an herbal medicine that has been clinically used to promote body fluid production. Previous works demonstrated that D. officinale polysaccharides could ameliorate symptoms of salivary secretion of patients with Sjögren ʼs syndrome and in a respective mice model. In the present study, we investigated the underlying mechanism by which D. officinale polysaccharides activate M3 muscarinic receptors and induce extracellular calcium influx, leading to the translocation of aquaporin 5, awater channel protein, to the apical membrane of human submandibular gland epithelial cells. Enzymatic treatment of D. officinale polysaccharides suggested that they are hydrolyzed but do not permeate cell membranes. This finding supports the pharmacological activity of D. officinale polysaccharides to promote salivary secretion.
Persistent Identifierhttp://hdl.handle.net/10722/212315

 

DC FieldValueLanguage
dc.contributor.authorLin, XIANG-
dc.contributor.authorLiu, JINGYI-
dc.contributor.authorChung, WINGYAN-
dc.contributor.authorSze, Stephen Cho-Wing-
dc.contributor.authorLi, HANYAN-
dc.contributor.authorLao, L-
dc.contributor.authorZhang, Y-
dc.date.accessioned2015-07-21T02:32:12Z-
dc.date.available2015-07-21T02:32:12Z-
dc.date.issued2015-
dc.identifier.citationPlanta Medica, 2015, v. 81 n. 2, p. 130-137-
dc.identifier.urihttp://hdl.handle.net/10722/212315-
dc.description.abstractDendrobium officinale is an herbal medicine that has been clinically used to promote body fluid production. Previous works demonstrated that D. officinale polysaccharides could ameliorate symptoms of salivary secretion of patients with Sjögren ʼs syndrome and in a respective mice model. In the present study, we investigated the underlying mechanism by which D. officinale polysaccharides activate M3 muscarinic receptors and induce extracellular calcium influx, leading to the translocation of aquaporin 5, awater channel protein, to the apical membrane of human submandibular gland epithelial cells. Enzymatic treatment of D. officinale polysaccharides suggested that they are hydrolyzed but do not permeate cell membranes. This finding supports the pharmacological activity of D. officinale polysaccharides to promote salivary secretion.-
dc.languageeng-
dc.relation.ispartofPlanta Medica-
dc.titlePolysaccharides of Dendrobium officinale Induce Aquaporin 5 Translocation by Activating M3 Muscarinic Receptors-
dc.typeArticle-
dc.identifier.emailLao, L: lxlao1@hku.hk-
dc.identifier.emailZhang, Y: ybzhang@hku.hk-
dc.identifier.authorityLao, L=rp01784-
dc.identifier.authorityZhang, Y=rp01410-
dc.identifier.doi10.1055/s-0034-1383411-
dc.identifier.hkuros245978-
dc.identifier.hkuros253077-
dc.identifier.spage130-
dc.identifier.epage137-

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