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- Publisher Website: 10.1055/s-0034-1383411
- Scopus: eid_2-s2.0-84921712688
- PMID: 25590366
- WOS: WOS:000348599400005
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Article: Polysaccharides of Dendrobium officinale Induce Aquaporin 5 Translocation by Activating M3 Muscarinic Receptors
Title | Polysaccharides of Dendrobium officinale Induce Aquaporin 5 Translocation by Activating M3 Muscarinic Receptors |
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Authors | |
Keywords | aquaporin 5 Dendrobium officinale M3 muscarinic receptor Orchidaceae polysaccharides |
Issue Date | 2015 |
Citation | Planta Medica, 2015, v. 81 n. 2, p. 130-137 How to Cite? |
Abstract | Dendrobium officinale is an herbal medicine that has been clinically used to promote body fluid production. Previous works demonstrated that D. officinale polysaccharides could ameliorate symptoms of salivary secretion of patients with Sjögren ʼs syndrome and in a respective mice model. In the present study, we investigated the underlying mechanism by which D. officinale polysaccharides activate M3 muscarinic receptors and induce extracellular calcium influx, leading to the translocation of aquaporin 5, awater channel protein, to the apical membrane of human submandibular gland epithelial cells. Enzymatic treatment of D. officinale polysaccharides suggested that they are hydrolyzed but do not permeate cell membranes. This finding supports the pharmacological activity of D. officinale polysaccharides to promote salivary secretion. |
Persistent Identifier | http://hdl.handle.net/10722/212315 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.445 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lin, Xiang | - |
dc.contributor.author | Liu, Jingyi | - |
dc.contributor.author | Chung, Wingyan | - |
dc.contributor.author | Sze, Stephen Cho-Wing | - |
dc.contributor.author | Li, Hanyan | - |
dc.contributor.author | Lao, L | - |
dc.contributor.author | Zhang, Y | - |
dc.date.accessioned | 2015-07-21T02:32:12Z | - |
dc.date.available | 2015-07-21T02:32:12Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Planta Medica, 2015, v. 81 n. 2, p. 130-137 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | http://hdl.handle.net/10722/212315 | - |
dc.description.abstract | Dendrobium officinale is an herbal medicine that has been clinically used to promote body fluid production. Previous works demonstrated that D. officinale polysaccharides could ameliorate symptoms of salivary secretion of patients with Sjögren ʼs syndrome and in a respective mice model. In the present study, we investigated the underlying mechanism by which D. officinale polysaccharides activate M3 muscarinic receptors and induce extracellular calcium influx, leading to the translocation of aquaporin 5, awater channel protein, to the apical membrane of human submandibular gland epithelial cells. Enzymatic treatment of D. officinale polysaccharides suggested that they are hydrolyzed but do not permeate cell membranes. This finding supports the pharmacological activity of D. officinale polysaccharides to promote salivary secretion. | - |
dc.language | eng | - |
dc.relation.ispartof | Planta Medica | - |
dc.subject | aquaporin 5 | - |
dc.subject | Dendrobium officinale | - |
dc.subject | M3 muscarinic receptor | - |
dc.subject | Orchidaceae | - |
dc.subject | polysaccharides | - |
dc.title | Polysaccharides of Dendrobium officinale Induce Aquaporin 5 Translocation by Activating M3 Muscarinic Receptors | - |
dc.type | Article | - |
dc.identifier.email | Lao, L: lxlao1@hku.hk | - |
dc.identifier.email | Zhang, Y: ybzhang@hku.hk | - |
dc.identifier.authority | Lao, L=rp01784 | - |
dc.identifier.authority | Zhang, Y=rp01410 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1055/s-0034-1383411 | - |
dc.identifier.pmid | 25590366 | - |
dc.identifier.scopus | eid_2-s2.0-84921712688 | - |
dc.identifier.hkuros | 245978 | - |
dc.identifier.hkuros | 253077 | - |
dc.identifier.spage | 130 | - |
dc.identifier.epage | 137 | - |
dc.identifier.eissn | 1439-0221 | - |
dc.identifier.isi | WOS:000348599400005 | - |
dc.identifier.issnl | 0032-0943 | - |