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Conference Paper: Salivary IL-1 beta, 'Red Complex Bacteria' and maintenance frequency as predictors of periimplant crevicular fluid IL-1 beta response in periimplant mucositis

TitleSalivary IL-1 beta, 'Red Complex Bacteria' and maintenance frequency as predictors of periimplant crevicular fluid IL-1 beta response in periimplant mucositis
Authors
KeywordsPeriodontitis
Periodontal pathogens
Periimplant disease
Salivary Biomarkers
Issue Date2015
PublisherSage Publications, Inc.
Citation
The 2015 IADR/AADR/CADR General Session & Exhibition, Boston, MA., 11-14 March 2015. In Journal of Dental Research Meeting Abstracts, 2015, v. 94 Spec. Iss. A, abstract no. 3282 How to Cite?
AbstractOBJECTIVES: This study investigated the association of periimplant crevicular fluid (PICF) IL-1 beta levels with salivary ‘red complex’ periodontopathogen counts, salivary IL-1beta levels, maintenance visit frequency and a cumulative variable, in periodontally susceptible (P) and non-susceptible (NP) subjects with periimplant mucositis. METHODS: 87 healthy partially edentulous subjects under maintenance care were recruited, including 40 with history of chronic periodontitis (periodontally susceptible; P) and 47 without the history (periodontally non-suscpetible; NP). All subjects had at least one implant with periimplant mucositis. Clinical and demographic measures were recorded. IL-1 beta levels in unstimulated whole saliva and PICF were measured by ELISA, respectively. Whereas, the ‘red complex’ bacteria counts in saliva were assessed by real-time PCR. Subjects were scored according to threshold salivary pathogen levels {more than 5 Log (10) counts} and then assigned a ‘Red Complex Score’. Scores were assigned each for quartiles of salivary and PICF IL-1beta levels (1-4) and maintenance frequency (1-3). A cumulative variable C computed as a product of maintenance score, salivary IL-1 beta and ‘Red Complex Score’. Receiver Operating Curves were computed for predicting ‘high (score 4)’ PICF IL-1 beta responders. RESULTS: No significant difference in salivary and PICF IL-1 beta levels as well as periodonpathogen counts was found between the P and NP groups. The ‘Red Complex Score’ (auc=0.758, p=0.010), salivary IL-1beta levels (auc=0.708, p= 0.038) and C values (auc=0.784, p=0.005) were all significant discriminators of the ‘high’ PICF IL-1 beta responders in the NP group, but not in the P group. CONCLUSIONS: The salivary biomarker levels including IL-1 beta, periodontal pathogens and maintenance frequency could not be used to discriminate the ‘high’ PICF 1L-1 beta responders among periimplant mucositis subjects with inherent periodontal disease susceptibility. This finding suggests there may be larger inherent variability in individual host responses to microbial challenge within the disease-susceptible group.
DescriptionePoster: abstract no. 3282
Persistent Identifierhttp://hdl.handle.net/10722/212175
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714

 

DC FieldValueLanguage
dc.contributor.authorAcharya, A-
dc.contributor.authorKoh, ML-
dc.contributor.authorKheur, S-
dc.contributor.authorWatt, R-
dc.contributor.authorJin, L-
dc.contributor.authorMattheos, N-
dc.date.accessioned2015-07-21T02:26:17Z-
dc.date.available2015-07-21T02:26:17Z-
dc.date.issued2015-
dc.identifier.citationThe 2015 IADR/AADR/CADR General Session & Exhibition, Boston, MA., 11-14 March 2015. In Journal of Dental Research Meeting Abstracts, 2015, v. 94 Spec. Iss. A, abstract no. 3282-
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10722/212175-
dc.descriptionePoster: abstract no. 3282-
dc.description.abstractOBJECTIVES: This study investigated the association of periimplant crevicular fluid (PICF) IL-1 beta levels with salivary ‘red complex’ periodontopathogen counts, salivary IL-1beta levels, maintenance visit frequency and a cumulative variable, in periodontally susceptible (P) and non-susceptible (NP) subjects with periimplant mucositis. METHODS: 87 healthy partially edentulous subjects under maintenance care were recruited, including 40 with history of chronic periodontitis (periodontally susceptible; P) and 47 without the history (periodontally non-suscpetible; NP). All subjects had at least one implant with periimplant mucositis. Clinical and demographic measures were recorded. IL-1 beta levels in unstimulated whole saliva and PICF were measured by ELISA, respectively. Whereas, the ‘red complex’ bacteria counts in saliva were assessed by real-time PCR. Subjects were scored according to threshold salivary pathogen levels {more than 5 Log (10) counts} and then assigned a ‘Red Complex Score’. Scores were assigned each for quartiles of salivary and PICF IL-1beta levels (1-4) and maintenance frequency (1-3). A cumulative variable C computed as a product of maintenance score, salivary IL-1 beta and ‘Red Complex Score’. Receiver Operating Curves were computed for predicting ‘high (score 4)’ PICF IL-1 beta responders. RESULTS: No significant difference in salivary and PICF IL-1 beta levels as well as periodonpathogen counts was found between the P and NP groups. The ‘Red Complex Score’ (auc=0.758, p=0.010), salivary IL-1beta levels (auc=0.708, p= 0.038) and C values (auc=0.784, p=0.005) were all significant discriminators of the ‘high’ PICF IL-1 beta responders in the NP group, but not in the P group. CONCLUSIONS: The salivary biomarker levels including IL-1 beta, periodontal pathogens and maintenance frequency could not be used to discriminate the ‘high’ PICF 1L-1 beta responders among periimplant mucositis subjects with inherent periodontal disease susceptibility. This finding suggests there may be larger inherent variability in individual host responses to microbial challenge within the disease-susceptible group.-
dc.languageeng-
dc.publisherSage Publications, Inc.-
dc.relation.ispartofJournal of Dental Research Meeting Abstracts-
dc.rightsJournal of Dental Research Meeting Abstracts. Copyright © Sage Publications, Inc.-
dc.subjectPeriodontitis-
dc.subjectPeriodontal pathogens-
dc.subjectPeriimplant disease-
dc.subjectSalivary Biomarkers-
dc.titleSalivary IL-1 beta, 'Red Complex Bacteria' and maintenance frequency as predictors of periimplant crevicular fluid IL-1 beta response in periimplant mucositis-
dc.typeConference_Paper-
dc.identifier.emailWatt, R: rmwatt@hku.hk-
dc.identifier.emailJin, L: ljjin@hkucc.hku.hk-
dc.identifier.emailMattheos, N: mattheos@hku.hk-
dc.identifier.authorityWatt, R=rp00043-
dc.identifier.authorityJin, L=rp00028-
dc.identifier.authorityMattheos, N=rp01662-
dc.identifier.hkuros245720-
dc.identifier.volume94-
dc.identifier.issueSpec. Iss. A-
dc.publisher.placeUnited States-

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