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Conference Paper: Lipid subclasses profiles and oxidative stress in aggressive periodontitis before and after treatment

TitleLipid subclasses profiles and oxidative stress in aggressive periodontitis before and after treatment
Authors
KeywordsGenetic
Periodontitis
Lipid
Aggressive
Oxidative
Issue Date2015
PublisherSage Publications, Inc.
Citation
The 2015 IADR/AADR/CADR General Session & Exhibition, Boston, MA., 11-14 March 2015. In Journal of Dental Research Meeting Abstracts, 2015, v. 94 Spec. Iss. A, abstract no. 2028 How to Cite?
AbstractOBJECTIVES: The aim of this study was to investigate the lipid and oxidative stress profiles in aggressive periodontitis (AgP) patients, and to relate them to clinical variables and IL-6 genetic variants. METHODS: Twelve non-smoking Caucasian AgP patients selected based on their IL6 haplotypes underwent periodontal non-surgical and surgical treatment. Peripheral blood samples taken at baseline and at 6 different time-points after treatment were processed to determine lipid profiles (cholesterol, triglycerides, HDL and LDL subclasses) and oxidative stress markers (glutathione and total lipid hydroperoxide levels).RESULTS: HDL were the highest represented lipoproteins (38%), followed by IDL (26%), VLDL (20%), and LDL (16%). Among LDL, there was a prevalence of large LDL (LDL-1 and LDL-2), with a very small prevalence of small LDL. The lipid profile did not consistently change after treatment up to 3 months after surgery. Periodontal disease severity was associated with changes in concentrations of LDL (p=0.01), large IDL (p=0.04), medium IDL (p=0.004), small IDL (p<0.001), LDL-3 and LDL-2 and LDL-3 (p<0.001) and average LDL size (p<0.001). The IL6 haplotypes were associated with total cholesterol, triglycerides, HDL and LDL subclasses after adjusting for confounders (p<0.01). No associations were detected between clinical and genetic variables and oxidative stress parameters. CONCLUSIONS: Disease severity and IL6 haplotypes may influence lipid profiles in aggressive periodontitis.
DescriptionePoster: abstract no. 2028
Persistent Identifierhttp://hdl.handle.net/10722/212169
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714

 

DC FieldValueLanguage
dc.contributor.authorNibali, L-
dc.contributor.authorRizzo, M-
dc.contributor.authorLivolti, GL-
dc.contributor.authorD'Aiuto, F-
dc.contributor.authorPelekos, G-
dc.contributor.authorDonos, N-
dc.date.accessioned2015-07-21T02:25:55Z-
dc.date.available2015-07-21T02:25:55Z-
dc.date.issued2015-
dc.identifier.citationThe 2015 IADR/AADR/CADR General Session & Exhibition, Boston, MA., 11-14 March 2015. In Journal of Dental Research Meeting Abstracts, 2015, v. 94 Spec. Iss. A, abstract no. 2028-
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10722/212169-
dc.descriptionePoster: abstract no. 2028-
dc.description.abstractOBJECTIVES: The aim of this study was to investigate the lipid and oxidative stress profiles in aggressive periodontitis (AgP) patients, and to relate them to clinical variables and IL-6 genetic variants. METHODS: Twelve non-smoking Caucasian AgP patients selected based on their IL6 haplotypes underwent periodontal non-surgical and surgical treatment. Peripheral blood samples taken at baseline and at 6 different time-points after treatment were processed to determine lipid profiles (cholesterol, triglycerides, HDL and LDL subclasses) and oxidative stress markers (glutathione and total lipid hydroperoxide levels).RESULTS: HDL were the highest represented lipoproteins (38%), followed by IDL (26%), VLDL (20%), and LDL (16%). Among LDL, there was a prevalence of large LDL (LDL-1 and LDL-2), with a very small prevalence of small LDL. The lipid profile did not consistently change after treatment up to 3 months after surgery. Periodontal disease severity was associated with changes in concentrations of LDL (p=0.01), large IDL (p=0.04), medium IDL (p=0.004), small IDL (p<0.001), LDL-3 and LDL-2 and LDL-3 (p<0.001) and average LDL size (p<0.001). The IL6 haplotypes were associated with total cholesterol, triglycerides, HDL and LDL subclasses after adjusting for confounders (p<0.01). No associations were detected between clinical and genetic variables and oxidative stress parameters. CONCLUSIONS: Disease severity and IL6 haplotypes may influence lipid profiles in aggressive periodontitis.-
dc.languageeng-
dc.publisherSage Publications, Inc.-
dc.relation.ispartofJournal of Dental Research Meeting Abstracts-
dc.rightsJournal of Dental Research Meeting Abstracts. Copyright © Sage Publications, Inc.-
dc.subjectGenetic-
dc.subjectPeriodontitis-
dc.subjectLipid-
dc.subjectAggressive-
dc.subjectOxidative-
dc.titleLipid subclasses profiles and oxidative stress in aggressive periodontitis before and after treatment-
dc.typeConference_Paper-
dc.identifier.emailPelekos, G: george74@hku.hk-
dc.identifier.authorityPelekos, G=rp01894-
dc.identifier.hkuros245710-
dc.identifier.volume94-
dc.identifier.issueSpec. Iss. A-
dc.publisher.placeUnited States-

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