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Article: Distributions of colorectal cancer in two chinese cities with contrasting colorectal cancer epidemiology

TitleDistributions of colorectal cancer in two chinese cities with contrasting colorectal cancer epidemiology
Authors
Issue Date2015
Citation
Journal of Gastroenterology and Hepatology, 2015 How to Cite?
AbstractBACKGROUND AND AIM: The incidence of colorectal cancer (CRC) is rising rapidly in Chinese. We studied the anatomic distributions and characteristics of CRC in Hong Kong (HK) and Chongqing (CQ) with different CRC epidemiology. METHODS: It was a retrospective study conducted in three large regional hospitals of the two cities. We identified all patients newly diagnosed with CRC between 2003 and 2012. The distribution and characteristics of CRC of the two cities were compared. RESULTS: 3,664 new cases of CRC were diagnosed within the study period. CRC was more common in men (>56%) in both cities. The mean age at diagnosis was significantly younger in CQ, the lower prevalence area, than in HK (62.1 vs 70.4 years; P <0.001). Rectal cancer was the predominant (61.3%) cancer in CQ, but only 18% of cancers in HK were rectal cancer (P = 0.0001). Right-sided colonic cancer, however, was more common in HK than CQ (27.2% vs 17.4%; P <0.001). Women had more right-sided colonic cancer than men in both cities (P < 0.002), and there was an age-related increase in right-sided colonic cancer in HK but not in CQ. Multivariate analysis showed that older age, female and living in HK were independent risk factors associated with right-sided colonic cancer. CONCLUSIONS: There are significant differences in the distribution of CRC between HK and CQ. The discrepancy may be partly accounted by older population and an increase in proximal colonic cancer, particularly in women, in HK.
Persistent Identifierhttp://hdl.handle.net/10722/211826

 

DC FieldValueLanguage
dc.contributor.authorLeung, WK-
dc.contributor.authorChen, WQ-
dc.contributor.authorGu, L-
dc.contributor.authorLong, D-
dc.contributor.authorLaw, WL-
dc.date.accessioned2015-07-21T02:12:12Z-
dc.date.available2015-07-21T02:12:12Z-
dc.date.issued2015-
dc.identifier.citationJournal of Gastroenterology and Hepatology, 2015-
dc.identifier.urihttp://hdl.handle.net/10722/211826-
dc.description.abstractBACKGROUND AND AIM: The incidence of colorectal cancer (CRC) is rising rapidly in Chinese. We studied the anatomic distributions and characteristics of CRC in Hong Kong (HK) and Chongqing (CQ) with different CRC epidemiology. METHODS: It was a retrospective study conducted in three large regional hospitals of the two cities. We identified all patients newly diagnosed with CRC between 2003 and 2012. The distribution and characteristics of CRC of the two cities were compared. RESULTS: 3,664 new cases of CRC were diagnosed within the study period. CRC was more common in men (>56%) in both cities. The mean age at diagnosis was significantly younger in CQ, the lower prevalence area, than in HK (62.1 vs 70.4 years; P <0.001). Rectal cancer was the predominant (61.3%) cancer in CQ, but only 18% of cancers in HK were rectal cancer (P = 0.0001). Right-sided colonic cancer, however, was more common in HK than CQ (27.2% vs 17.4%; P <0.001). Women had more right-sided colonic cancer than men in both cities (P < 0.002), and there was an age-related increase in right-sided colonic cancer in HK but not in CQ. Multivariate analysis showed that older age, female and living in HK were independent risk factors associated with right-sided colonic cancer. CONCLUSIONS: There are significant differences in the distribution of CRC between HK and CQ. The discrepancy may be partly accounted by older population and an increase in proximal colonic cancer, particularly in women, in HK.-
dc.languageeng-
dc.relation.ispartofJournal of Gastroenterology and Hepatology-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis is the pre-peer reviewed version of the following article: [Journal of Gastroenterology and Hepatology, 2015], which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1111/jgh.13018/abstract]. Authors are not required to remove preprints posted prior to acceptance of the submitted version.-
dc.titleDistributions of colorectal cancer in two chinese cities with contrasting colorectal cancer epidemiology-
dc.typeArticle-
dc.identifier.emailLeung, WK: waikleung@hku.hk-
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hk-
dc.identifier.authorityLeung, WK=rp01479-
dc.identifier.authorityLaw, WL=rp00436-
dc.description.naturepreprint-
dc.identifier.doi10.1111/jgh.13018-
dc.identifier.hkuros245417-

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