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Article: The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma

TitleThe interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma
Authors
Issue Date2014
PublisherSun Yat-Sen University Cancer Center. The Journal's web site is located at http://www.cjcsysu.cn/
Citation
Chinese Journal of Cancer, 2014, v. 33 n. 11, p. 556-568 How to Cite?
AbstractThe interplay between host cell genetics and Epstein-Barr virus (EBV) infection contributes to the development of nasopharyngeal carcinoma (NPC). Understanding the host genetic and epigenetic alterations and the influence of EBV on cell signaling and host gene regulation will aid in understanding the molecular pathogenesis of NPC and provide useful biomarkers and targets for diagnosis and therapy. In this review, we provide an update of the oncogenes and tumor suppressor genes associated with NPC, as well as genes associated with NPC risk including those involved in carcinogen detoxification and DNA repair. We also describe the importance of host genetics that govern the human leukocyte antigen (HLA) complex and immune responses, and we describe the impact of EBV infection on host cell signaling changes and epigenetic regulation of gene expression. High-power genomic sequencing approaches are needed to elucidate the genetic basis for inherited susceptibility to NPC and to identify the genes and pathways driving its molecular pathogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/211735
ISSN
2015 Impact Factor: 2.814
2015 SCImago Journal Rankings: 1.081
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLung, ML-
dc.contributor.authorCheung, AKL-
dc.contributor.authorKo, JMY-
dc.contributor.authorLung, HL-
dc.contributor.authorCheng, Y-
dc.contributor.authorDai, W-
dc.date.accessioned2015-07-21T02:09:25Z-
dc.date.available2015-07-21T02:09:25Z-
dc.date.issued2014-
dc.identifier.citationChinese Journal of Cancer, 2014, v. 33 n. 11, p. 556-568-
dc.identifier.issn1000-467X-
dc.identifier.urihttp://hdl.handle.net/10722/211735-
dc.description.abstractThe interplay between host cell genetics and Epstein-Barr virus (EBV) infection contributes to the development of nasopharyngeal carcinoma (NPC). Understanding the host genetic and epigenetic alterations and the influence of EBV on cell signaling and host gene regulation will aid in understanding the molecular pathogenesis of NPC and provide useful biomarkers and targets for diagnosis and therapy. In this review, we provide an update of the oncogenes and tumor suppressor genes associated with NPC, as well as genes associated with NPC risk including those involved in carcinogen detoxification and DNA repair. We also describe the importance of host genetics that govern the human leukocyte antigen (HLA) complex and immune responses, and we describe the impact of EBV infection on host cell signaling changes and epigenetic regulation of gene expression. High-power genomic sequencing approaches are needed to elucidate the genetic basis for inherited susceptibility to NPC and to identify the genes and pathways driving its molecular pathogenesis.-
dc.languageeng-
dc.publisherSun Yat-Sen University Cancer Center. The Journal's web site is located at http://www.cjcsysu.cn/-
dc.relation.ispartofChinese Journal of Cancer-
dc.titleThe interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma-
dc.typeArticle-
dc.identifier.emailLung, ML: mlilung@hku.hk-
dc.identifier.emailCheung, AKL: arthurhk@hku.hk-
dc.identifier.emailKo, JMY: joko@hku.hk-
dc.identifier.emailLung, HL: hllung2@hku.hk-
dc.identifier.emailCheng, Y: yuecheng@HKUCC-COM.hku.hk-
dc.identifier.emailDai, W: weidai2@hku.hk-
dc.identifier.authorityLung, ML=rp00300-
dc.identifier.authorityCheung, AKL=rp01769-
dc.identifier.authorityKo, JMY=rp02011-
dc.identifier.authorityLung, HL=rp00299-
dc.identifier.authorityCheng, Y=rp01320-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.5732/cjc.014.10170-
dc.identifier.pmid25367335-
dc.identifier.pmcidPMC4244319-
dc.identifier.hkuros244292-
dc.identifier.hkuros244976-
dc.identifier.volume33-
dc.identifier.issue11-
dc.identifier.spage556-
dc.identifier.epage568-
dc.publisher.placeChina-

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