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Article: Chemical biology of anticancer gold(III) and gold(I) complexes

TitleChemical biology of anticancer gold(III) and gold(I) complexes
Authors
Issue Date2015
Citation
Chemical Society Reviews, 2015 How to Cite?
AbstractGold complexes have recently gained increasing attention in the design of new metal-based anticancer therapeutics. Gold(iii) complexes are generally reactive/unstable under physiological conditions via intracellular redox reactions, and the intracellular AuIII to AuI reduction reaction has recently been "traced" by the introduction of appropriate fluorescent ligands. Similar to most Au(i) complexes, Au(iii) complexes can inhibit the activities of thiol-containing enzymes, including thioredoxin reductase, via ligand exchange reactions to form Au-S(Se) bonds. Nonetheless, there are examples of physiologically stable Au(iii) and Au(i) complexes, such as [Au(TPP)]Cl (H2TPP = 5,10,15,20-tetraphenylporphyrin) and [Au(dppe)2]Cl (dppe = 1,2-bis(diphenylphosphanyl)ethane), which are known to display highly potent in vitro and in vivo anticancer activities. In this review, we summarize our current understanding of anticancer gold complexes, including their mechanisms of action and the approaches adopted to improve their anticancer efficiency. Some recent examples of gold anticancer chemotherapeutics are highlighted.
Persistent Identifierhttp://hdl.handle.net/10722/211627

 

DC FieldValueLanguage
dc.contributor.authorZou, T-
dc.contributor.authorLum, CT-
dc.contributor.authorLok, CN-
dc.contributor.authorZhang, JJ-
dc.contributor.authorChe, CM-
dc.date.accessioned2015-07-21T02:05:44Z-
dc.date.available2015-07-21T02:05:44Z-
dc.date.issued2015-
dc.identifier.citationChemical Society Reviews, 2015-
dc.identifier.urihttp://hdl.handle.net/10722/211627-
dc.description.abstractGold complexes have recently gained increasing attention in the design of new metal-based anticancer therapeutics. Gold(iii) complexes are generally reactive/unstable under physiological conditions via intracellular redox reactions, and the intracellular AuIII to AuI reduction reaction has recently been "traced" by the introduction of appropriate fluorescent ligands. Similar to most Au(i) complexes, Au(iii) complexes can inhibit the activities of thiol-containing enzymes, including thioredoxin reductase, via ligand exchange reactions to form Au-S(Se) bonds. Nonetheless, there are examples of physiologically stable Au(iii) and Au(i) complexes, such as [Au(TPP)]Cl (H2TPP = 5,10,15,20-tetraphenylporphyrin) and [Au(dppe)2]Cl (dppe = 1,2-bis(diphenylphosphanyl)ethane), which are known to display highly potent in vitro and in vivo anticancer activities. In this review, we summarize our current understanding of anticancer gold complexes, including their mechanisms of action and the approaches adopted to improve their anticancer efficiency. Some recent examples of gold anticancer chemotherapeutics are highlighted.-
dc.languageeng-
dc.relation.ispartofChemical Society Reviews-
dc.titleChemical biology of anticancer gold(III) and gold(I) complexes-
dc.typeArticle-
dc.identifier.emailZou, T: zoutt@hku.hk-
dc.identifier.emailLum, CT: lumct@hku.hk-
dc.identifier.emailLok, CN: cnlok@hkucc.hku.hk-
dc.identifier.emailChe, CM: cmche@hku.hk-
dc.identifier.authorityLum, CT=rp00757-
dc.identifier.authorityLok, CN=rp00752-
dc.identifier.authorityChe, CM=rp00670-
dc.identifier.doi10.1039/C5CS00132C-
dc.identifier.hkuros244430-

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