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Article: Total Synthesis of (-)-Dolastatrienol.

TitleTotal Synthesis of (-)-Dolastatrienol.
Authors
Keywordscarbenes
cascade reaction
natural products
rhodium
total synthesis
Issue Date2015
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451
Citation
Chemistry - An Asian Journal, 2015, v. 10 n. 4, p. 1042-1049 How to Cite?
AbstractThe first asymmetric total synthesis of the tricyclic diterpenoid natural product (-)-dolastatrienol has been accomplished using a rhodium(II)-catalyzed carbene cyclization cycloaddition cascade reaction as the key step to construct the [5.4.0]carbobicyclic core. An intramolecular Heck reaction furnished the tricyclic skeleton and a challenging methylenation completed the synthesis of the target.
Persistent Identifierhttp://hdl.handle.net/10722/211624
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 0.846
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, LT-
dc.contributor.authorChiu, P-
dc.date.accessioned2015-07-21T02:05:34Z-
dc.date.available2015-07-21T02:05:34Z-
dc.date.issued2015-
dc.identifier.citationChemistry - An Asian Journal, 2015, v. 10 n. 4, p. 1042-1049-
dc.identifier.issn1861-4728-
dc.identifier.urihttp://hdl.handle.net/10722/211624-
dc.description.abstractThe first asymmetric total synthesis of the tricyclic diterpenoid natural product (-)-dolastatrienol has been accomplished using a rhodium(II)-catalyzed carbene cyclization cycloaddition cascade reaction as the key step to construct the [5.4.0]carbobicyclic core. An intramolecular Heck reaction furnished the tricyclic skeleton and a challenging methylenation completed the synthesis of the target.-
dc.languageeng-
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451-
dc.relation.ispartofChemistry - An Asian Journal-
dc.rightspostprint: This is the accepted version of the following article: FULL CITE, which has been published in final form at [Link to final article]. Preprint This is the pre-peer reviewed version of the following article: FULL CITE, which has been published in final form at [Link to final article].-
dc.subjectcarbenes-
dc.subjectcascade reaction-
dc.subjectnatural products-
dc.subjectrhodium-
dc.subjecttotal synthesis-
dc.titleTotal Synthesis of (-)-Dolastatrienol.-
dc.typeArticle-
dc.identifier.emailChiu, P: pchiu@hku.hk-
dc.identifier.authorityLeung, LT=rp00734-
dc.identifier.authorityChiu, P=rp00680-
dc.identifier.doi10.1002/asia.201403325-
dc.identifier.pmid25556852-
dc.identifier.scopuseid_2-s2.0-85027920058-
dc.identifier.hkuros244257-
dc.identifier.volume10-
dc.identifier.issue4-
dc.identifier.spage1042-
dc.identifier.epage1049-
dc.identifier.isiWOS:000351623600032-
dc.publisher.placeGermany-
dc.identifier.issnl1861-471X-

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