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- Publisher Website: 10.1002/asia.201403325
- Scopus: eid_2-s2.0-85027920058
- PMID: 25556852
- WOS: WOS:000351623600032
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Article: Total Synthesis of (-)-Dolastatrienol.
| Title | Total Synthesis of (-)-Dolastatrienol. |
|---|---|
| Authors | |
| Keywords | carbenes cascade reaction natural products rhodium total synthesis |
| Issue Date | 2015 |
| Publisher | Wiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451 |
| Citation | Chemistry - An Asian Journal, 2015, v. 10 n. 4, p. 1042-1049 How to Cite? |
| Abstract | The first asymmetric total synthesis of the tricyclic diterpenoid natural product (-)-dolastatrienol has been accomplished using a rhodium(II)-catalyzed carbene cyclization cycloaddition cascade reaction as the key step to construct the [5.4.0]carbobicyclic core. An intramolecular Heck reaction furnished the tricyclic skeleton and a challenging methylenation completed the synthesis of the target. |
| Persistent Identifier | http://hdl.handle.net/10722/211624 |
| ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.846 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Leung, LT | - |
| dc.contributor.author | Chiu, P | - |
| dc.date.accessioned | 2015-07-21T02:05:34Z | - |
| dc.date.available | 2015-07-21T02:05:34Z | - |
| dc.date.issued | 2015 | - |
| dc.identifier.citation | Chemistry - An Asian Journal, 2015, v. 10 n. 4, p. 1042-1049 | - |
| dc.identifier.issn | 1861-4728 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/211624 | - |
| dc.description.abstract | The first asymmetric total synthesis of the tricyclic diterpenoid natural product (-)-dolastatrienol has been accomplished using a rhodium(II)-catalyzed carbene cyclization cycloaddition cascade reaction as the key step to construct the [5.4.0]carbobicyclic core. An intramolecular Heck reaction furnished the tricyclic skeleton and a challenging methylenation completed the synthesis of the target. | - |
| dc.language | eng | - |
| dc.publisher | Wiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451 | - |
| dc.relation.ispartof | Chemistry - An Asian Journal | - |
| dc.rights | postprint: This is the accepted version of the following article: FULL CITE, which has been published in final form at [Link to final article]. Preprint This is the pre-peer reviewed version of the following article: FULL CITE, which has been published in final form at [Link to final article]. | - |
| dc.subject | carbenes | - |
| dc.subject | cascade reaction | - |
| dc.subject | natural products | - |
| dc.subject | rhodium | - |
| dc.subject | total synthesis | - |
| dc.title | Total Synthesis of (-)-Dolastatrienol. | - |
| dc.type | Article | - |
| dc.identifier.email | Chiu, P: pchiu@hku.hk | - |
| dc.identifier.authority | Leung, LT=rp00734 | - |
| dc.identifier.authority | Chiu, P=rp00680 | - |
| dc.identifier.doi | 10.1002/asia.201403325 | - |
| dc.identifier.pmid | 25556852 | - |
| dc.identifier.scopus | eid_2-s2.0-85027920058 | - |
| dc.identifier.hkuros | 244257 | - |
| dc.identifier.volume | 10 | - |
| dc.identifier.issue | 4 | - |
| dc.identifier.spage | 1042 | - |
| dc.identifier.epage | 1049 | - |
| dc.identifier.isi | WOS:000351623600032 | - |
| dc.publisher.place | Germany | - |
| dc.identifier.issnl | 1861-471X | - |