File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Stem cells and aberrant signaling of molecular systems in skin aging

TitleStem cells and aberrant signaling of molecular systems in skin aging
Authors
Issue Date2015
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/arr
Citation
Ageing Research Reviews, 2015, v. 19, p. 8-21 How to Cite?
AbstractThe skin is the body's largest organ and it is able to self-repair throughout an individual's life. With advanced age, skin is prone to degenerate in response to damage. Although cosmetic surgery has been widely adopted to rejuvinate skin, we are far from a clear understanding of the mechanisms responsible for skin aging. Recently, adult skin-resident stem/progenitor cells, growth arrest, senescence or apoptotic death and dysfunction caused by alterations in key signaling genes, such as Ras/Raf/MEK/ERK, PI3K/Akt-kinases, Wnt, p21 and p53, have been shown to play a vital role in skin regeneration. Simultaneously, enhanced telomere attrition, hormone exhaustion, oxidative stress, genetic events and ultraviolet radiation exposure that result in severe DNA damage, genomic instability and epigenetic mutations also contribute to skin aging. Therefore, cell replacement and targeting of the molecular systems found in skin hold great promise for controlling or even curing skin aging. Copyright © 2014 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/210765
ISSN
2015 Impact Factor: 7.526
2015 SCImago Journal Rankings: 3.289

 

DC FieldValueLanguage
dc.contributor.authorPENG, Y-
dc.contributor.authorXuan, M-
dc.contributor.authorLeung, VYL-
dc.contributor.authorCheng, B-
dc.date.accessioned2015-06-23T05:49:56Z-
dc.date.available2015-06-23T05:49:56Z-
dc.date.issued2015-
dc.identifier.citationAgeing Research Reviews, 2015, v. 19, p. 8-21-
dc.identifier.issn1568-1637-
dc.identifier.urihttp://hdl.handle.net/10722/210765-
dc.description.abstractThe skin is the body's largest organ and it is able to self-repair throughout an individual's life. With advanced age, skin is prone to degenerate in response to damage. Although cosmetic surgery has been widely adopted to rejuvinate skin, we are far from a clear understanding of the mechanisms responsible for skin aging. Recently, adult skin-resident stem/progenitor cells, growth arrest, senescence or apoptotic death and dysfunction caused by alterations in key signaling genes, such as Ras/Raf/MEK/ERK, PI3K/Akt-kinases, Wnt, p21 and p53, have been shown to play a vital role in skin regeneration. Simultaneously, enhanced telomere attrition, hormone exhaustion, oxidative stress, genetic events and ultraviolet radiation exposure that result in severe DNA damage, genomic instability and epigenetic mutations also contribute to skin aging. Therefore, cell replacement and targeting of the molecular systems found in skin hold great promise for controlling or even curing skin aging. Copyright © 2014 Elsevier B.V. All rights reserved.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/arr-
dc.relation.ispartofAgeing Research Reviews-
dc.titleStem cells and aberrant signaling of molecular systems in skin aging-
dc.typeArticle-
dc.identifier.emailLeung, VYL: vicleung@hku.hk-
dc.identifier.authorityLeung, VYL=rp01764-
dc.identifier.doi10.1016/j.arr.2014.10.006-
dc.identifier.pmid25446806-
dc.identifier.hkuros244031-
dc.identifier.volume19-
dc.identifier.spage8-
dc.identifier.epage21-
dc.publisher.placeIreland-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats