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Article: Synthesis of Highly-strained Cyclic Tetrapeptides via Peptide Hydrazide Based Ligation

TitleSynthesis of Highly-strained Cyclic Tetrapeptides via Peptide Hydrazide Based Ligation
通过基于多肽酰肼的化学连接反应合成高张力环状四肽
Authors
Issue Date2014
PublisherShanghai Institute of Organic Chemistry, Chinese Academy of. The Journal's web site is located at http://hxxb.periodicals.net.cn/default.html
Citation
Acta Chimica Sinica, 2014, v. 72 n. 12, p. 1197-1198 How to Cite?
化学学报, 2014, v. 72 n. 12, p. 1197-1198 How to Cite?
AbstractA series of highly-strained cyclic tetrapeptides were efficiently synthesized via peptide hydrazide based ligation, reported by Liu et al. Upon mild oxidative activation, the peptide hydrazide was transformed into a highly active peptide azide intermediate and then in situ converted into a peptide 4-mercaptophenylacetic acid (MPAA) thiol ester, which underwent native chemical ligation (NCL)-mediated cyclization to afford the desired cyclic tetrapeptides. After radical desulfurization, the product with alanine residue at the ligation site can be obtained.
Persistent Identifierhttp://hdl.handle.net/10722/210691

 

DC FieldValueLanguage
dc.contributor.authorLiu, H-
dc.contributor.authorLi, XC-
dc.date.accessioned2015-06-23T05:47:17Z-
dc.date.available2015-06-23T05:47:17Z-
dc.date.issued2014-
dc.identifier.citationActa Chimica Sinica, 2014, v. 72 n. 12, p. 1197-1198-
dc.identifier.citation化学学报, 2014, v. 72 n. 12, p. 1197-1198-
dc.identifier.urihttp://hdl.handle.net/10722/210691-
dc.description.abstractA series of highly-strained cyclic tetrapeptides were efficiently synthesized via peptide hydrazide based ligation, reported by Liu et al. Upon mild oxidative activation, the peptide hydrazide was transformed into a highly active peptide azide intermediate and then in situ converted into a peptide 4-mercaptophenylacetic acid (MPAA) thiol ester, which underwent native chemical ligation (NCL)-mediated cyclization to afford the desired cyclic tetrapeptides. After radical desulfurization, the product with alanine residue at the ligation site can be obtained.-
dc.languagechi-
dc.publisherShanghai Institute of Organic Chemistry, Chinese Academy of. The Journal's web site is located at http://hxxb.periodicals.net.cn/default.html-
dc.relation.ispartof化学学报-
dc.relation.ispartofActa Chimica Sinica-
dc.titleSynthesis of Highly-strained Cyclic Tetrapeptides via Peptide Hydrazide Based Ligation-
dc.title通过基于多肽酰肼的化学连接反应合成高张力环状四肽-
dc.typeArticle-
dc.identifier.emailLiu, H: liuhan@hku.hk-
dc.identifier.emailLi, XC: xuechenl@hku.hk-
dc.identifier.authorityLi, XC=rp00742-
dc.identifier.doi10.6023/A14110820-
dc.identifier.hkuros243697-
dc.identifier.volume72-
dc.identifier.issue12-
dc.identifier.spage1197-
dc.identifier.epage1198-

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