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- Publisher Website: 10.6023/A14110820
- Scopus: eid_2-s2.0-84921057421
- WOS: WOS:000348595100001
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Article: Synthesis of Highly-strained Cyclic Tetrapeptides via Peptide Hydrazide Based Ligation
Title | Synthesis of Highly-strained Cyclic Tetrapeptides via Peptide Hydrazide Based Ligation 通过基于多肽酰肼的化学连接反应合成高张力环状四肽 |
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Authors | |
Keywords | Chemical ligation Peptide hydrazide Cyclic tetrapeptide Radical desulfurization |
Issue Date | 2014 |
Publisher | Shanghai Institute of Organic Chemistry, Chinese Academy of. The Journal's web site is located at http://hxxb.periodicals.net.cn/default.html |
Citation | Acta Chimica Sinica, 2014, v. 72 n. 12, p. 1197-1198 How to Cite? 化学学报, 2014, v. 72 n. 12, p. 1197-1198 How to Cite? |
Abstract | A series of highly-strained cyclic tetrapeptides were efficiently synthesized via peptide hydrazide based ligation, reported by Liu et al. Upon mild oxidative activation, the peptide hydrazide was transformed into a highly active peptide azide intermediate and then in situ converted into a peptide 4-mercaptophenylacetic acid (MPAA) thiol ester, which underwent native chemical ligation (NCL)-mediated cyclization to afford the desired cyclic tetrapeptides. After radical desulfurization, the product with alanine residue at the ligation site can be obtained. |
Persistent Identifier | http://hdl.handle.net/10722/210691 |
ISSN | 2021 Impact Factor: 2.789 2020 SCImago Journal Rankings: 0.565 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, H | - |
dc.contributor.author | Li, XC | - |
dc.date.accessioned | 2015-06-23T05:47:17Z | - |
dc.date.available | 2015-06-23T05:47:17Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Acta Chimica Sinica, 2014, v. 72 n. 12, p. 1197-1198 | - |
dc.identifier.citation | 化学学报, 2014, v. 72 n. 12, p. 1197-1198 | - |
dc.identifier.issn | 0567-7351 | - |
dc.identifier.uri | http://hdl.handle.net/10722/210691 | - |
dc.description.abstract | A series of highly-strained cyclic tetrapeptides were efficiently synthesized via peptide hydrazide based ligation, reported by Liu et al. Upon mild oxidative activation, the peptide hydrazide was transformed into a highly active peptide azide intermediate and then in situ converted into a peptide 4-mercaptophenylacetic acid (MPAA) thiol ester, which underwent native chemical ligation (NCL)-mediated cyclization to afford the desired cyclic tetrapeptides. After radical desulfurization, the product with alanine residue at the ligation site can be obtained. | - |
dc.language | chi | - |
dc.publisher | Shanghai Institute of Organic Chemistry, Chinese Academy of. The Journal's web site is located at http://hxxb.periodicals.net.cn/default.html | - |
dc.relation.ispartof | 化学学报 | - |
dc.relation.ispartof | Acta Chimica Sinica | - |
dc.subject | Chemical ligation | - |
dc.subject | Peptide hydrazide | - |
dc.subject | Cyclic tetrapeptide | - |
dc.subject | Radical desulfurization | - |
dc.title | Synthesis of Highly-strained Cyclic Tetrapeptides via Peptide Hydrazide Based Ligation | - |
dc.title | 通过基于多肽酰肼的化学连接反应合成高张力环状四肽 | - |
dc.type | Article | - |
dc.identifier.email | Liu, H: liuhan@hku.hk | - |
dc.identifier.email | Li, XC: xuechenl@hku.hk | - |
dc.identifier.authority | Li, XC=rp00742 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.6023/A14110820 | - |
dc.identifier.scopus | eid_2-s2.0-84921057421 | - |
dc.identifier.hkuros | 243697 | - |
dc.identifier.volume | 72 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 1197 | - |
dc.identifier.epage | 1198 | - |
dc.identifier.isi | WOS:000348595100001 | - |
dc.publisher.place | Beijing | - |
dc.identifier.issnl | 0567-7351 | - |