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Article: Effects of calcium phosphate nanocrystals on osseointegration of titainium implant in irradiated bone

TitleEffects of calcium phosphate nanocrystals on osseointegration of titainium implant in irradiated bone
Authors
Issue Date2015
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html
Citation
BioMed Research International, 2015, v. 2015, article no. 783894 How to Cite?
AbstractRadiotherapy may compromise the integration of implant and cause implant loss. Implant surface modifications have the possibility of promoting cell attachment, cell growth, and bone formation which ultimately enhance the osseointegration process. The present study aimed to investigate the effects of calcium phosphate nanocrystals on implant osseointegration in irradiated bone. Sixteen rabbits were randomly assigned into control and nano-CaP groups, receiving implants with dual acid-etched surface or dual acid-etched surface discretely deposited of nanoscale calcium-phosphate crystals, respectively. The left leg of all the rabbits received 15 Gy radiation, followed by implants placement one week after. Four animals in each group were sacrificed after 4 and 12 weeks, respectively. Implant stability quotient (ISQ), ratio of bone volume to total volume (BV/TV), bone growth rate, and bone-to-implant contact (BIC) were evaluated. The nano-CaP group showed significantly higher ISQ (week 12, P = 0.031) and bone growth rate (week 6, P = 0.021; week 9, P = 0.001) than that in control group. No significant differences in BV/TV and BIC were found between two groups. Titanium implant surface modified with CaP nanocrystals provides a potential alternative to improve bone healing around implant in irradiated bone.
Persistent Identifierhttp://hdl.handle.net/10722/210677
ISSN
2015 Impact Factor: 2.134
2015 SCImago Journal Rankings: 0.725
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLi, JY-
dc.contributor.authorPow, EHN-
dc.contributor.authorZheng, LW-
dc.contributor.authorMa, L-
dc.contributor.authorKwong, DLW-
dc.contributor.authorCheung, LK-
dc.date.accessioned2015-06-23T05:46:01Z-
dc.date.available2015-06-23T05:46:01Z-
dc.date.issued2015-
dc.identifier.citationBioMed Research International, 2015, v. 2015, article no. 783894-
dc.identifier.issn2314-6133-
dc.identifier.urihttp://hdl.handle.net/10722/210677-
dc.description.abstractRadiotherapy may compromise the integration of implant and cause implant loss. Implant surface modifications have the possibility of promoting cell attachment, cell growth, and bone formation which ultimately enhance the osseointegration process. The present study aimed to investigate the effects of calcium phosphate nanocrystals on implant osseointegration in irradiated bone. Sixteen rabbits were randomly assigned into control and nano-CaP groups, receiving implants with dual acid-etched surface or dual acid-etched surface discretely deposited of nanoscale calcium-phosphate crystals, respectively. The left leg of all the rabbits received 15 Gy radiation, followed by implants placement one week after. Four animals in each group were sacrificed after 4 and 12 weeks, respectively. Implant stability quotient (ISQ), ratio of bone volume to total volume (BV/TV), bone growth rate, and bone-to-implant contact (BIC) were evaluated. The nano-CaP group showed significantly higher ISQ (week 12, P = 0.031) and bone growth rate (week 6, P = 0.021; week 9, P = 0.001) than that in control group. No significant differences in BV/TV and BIC were found between two groups. Titanium implant surface modified with CaP nanocrystals provides a potential alternative to improve bone healing around implant in irradiated bone.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html-
dc.relation.ispartofBioMed Research International-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleEffects of calcium phosphate nanocrystals on osseointegration of titainium implant in irradiated bone-
dc.typeArticle-
dc.identifier.emailPow, EHN: ehnpow@hku.hk-
dc.identifier.emailZheng, LW: lwzheng@hkucc.hku.hk-
dc.identifier.emailMa, L: lima@hku.hk-
dc.identifier.emailKwong, DLW: dlwkwong@hku.hk-
dc.identifier.emailCheung, LK: lkcheung@hkucc.hku.hk-
dc.identifier.authorityPow, EHN=rp00030-
dc.identifier.authorityZheng, LW=rp01411-
dc.identifier.authorityKwong, DLW=rp00414-
dc.identifier.authorityCheung, LK=rp00013-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2015/783894-
dc.identifier.pmid25685809-
dc.identifier.pmcidPMC4317600-
dc.identifier.hkuros244120-
dc.identifier.volume2015-
dc.publisher.placeUnited States-

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