granted patent: HEV antigenic peptide and its method

TitleHEV antigenic peptide and its method
Granted PatentCN 1391579
Granted Date2003-01-15
Priority Date1999-09-30 CA19992283538
Inventors
Issue Date2003
Citation
China Patent CN 1391579. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2003 How to Cite?
AbstractA highly immunoreactive viral peptide, pE2, is disclosed which is derived form the carboxy-terminal end region of ORF2 region of the hepatitis E virus (HEV) genome. A unique feature of the novel pE2 peptide is that it possesses conformational antigenic determinants which are only exposed when monomers of the peptide associate with one another through non-covalent interactions to naturally form homodimers. The novel pE2 peptide is proven to be highly reactive with sera from patients having current or past infection with HEV which suggests that the homodimer may mimic certain structural features of the HEV capsid protein. Furthermore, the antigenic activity of the pE2 peptide is strictly conformational in nature and therefore, exhibits immunochemical reactivity only when the peptide exists in a dimeric form.; Consequently, the antigenic activity is lost upon dissociation of the dimers, but the activity is restored when the monomers reassociate to form dimers. Moreover, diagnostic methods useful in detecting and diagnosing HEV infection, and the use of a vaccine composition effective in preventing hepatitis E virus infection in which the novel pE2 peptide is utilized are also disclosed.
Persistent Identifierhttp://hdl.handle.net/10722/210539

 

DC FieldValueLanguage
dc.date.accessioned2015-06-17T07:04:15Z-
dc.date.available2015-06-17T07:04:15Z-
dc.date.issued2003-
dc.identifier.citationChina Patent CN 1391579. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2003-
dc.identifier.urihttp://hdl.handle.net/10722/210539-
dc.description.abstractA highly immunoreactive viral peptide, pE2, is disclosed which is derived form the carboxy-terminal end region of ORF2 region of the hepatitis E virus (HEV) genome. A unique feature of the novel pE2 peptide is that it possesses conformational antigenic determinants which are only exposed when monomers of the peptide associate with one another through non-covalent interactions to naturally form homodimers. The novel pE2 peptide is proven to be highly reactive with sera from patients having current or past infection with HEV which suggests that the homodimer may mimic certain structural features of the HEV capsid protein. Furthermore, the antigenic activity of the pE2 peptide is strictly conformational in nature and therefore, exhibits immunochemical reactivity only when the peptide exists in a dimeric form.; Consequently, the antigenic activity is lost upon dissociation of the dimers, but the activity is restored when the monomers reassociate to form dimers. Moreover, diagnostic methods useful in detecting and diagnosing HEV infection, and the use of a vaccine composition effective in preventing hepatitis E virus infection in which the novel pE2 peptide is utilized are also disclosed.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documents-
dc.titleHEV antigenic peptide and its method-
dc.typePatent-
dc.description.naturepublished_or_final_version-
dc.contributor.inventorHONGJIE YAN-
dc.contributor.inventorJIZHONG ZHONG-
dc.contributor.inventorWENHAN WU-
patents.identifier.applicationCN 2000813582-
patents.identifier.applicationZL00813582.7-
patents.identifier.grantedCN 1391579-
patents.description.assigneeYANGSHENGTANG CO LTD [CN] -
patents.description.countryChina, PRC-
patents.date.granted2003-01-15-
patents.identifier.hkutechidMicro-1999-00251-6-
patents.date.application2000-09-28-
patents.date.priority1999-09-30 CA19992283538-
patents.description.cccn-
patents.relation.familyHK 1051544 (A1) 2006-01-13-
patents.relation.familyEP 1461357 (A2) 2004-09-29 -
patents.relation.familyCA 2283538 (A1) 2001-03-30-
patents.relation.familyBR 0014390 (A) 2003-09-30-
patents.relation.familyAU 7308200 (A) 2001-04-30-
patents.relation.familyCN 1195774 (C) 2005-04-06-
patents.relation.familyMX PA02003270 (A) 2003-08-20-
patents.relation.familyUS 7204989 (B1) 2007-04-17-
patents.relation.familyJP 4641695 (B2) 2011-03-02-
patents.relation.familyWO 0122916 (A2) 2001-04-05 -
patents.relation.familyJP 2004500041 (A) 2004-01-08 -
patents.description.kindA-
patents.typePatent_granted-

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