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  Patent History
  • Application
    US 12/4019058 2013-09-05
  • Granted
    US 20150064215 2015-03-05
  Patent Family
Supplementary

granted patent: THERAPEUTIC DELIVERY AND EXPRESSION SYSTEM, METHODS AND USES THEREOF

TitleTHERAPEUTIC DELIVERY AND EXPRESSION SYSTEM, METHODS AND USES THEREOF
Granted PatentUS 20150064215
Granted Date2015-03-05
Priority Date2013-09-05 US 12/4019058
Inventors
Issue Date2015
Citation
US Patent US 20150064215. Washington, DC: US Patent and Trademark Office (USPTO), 2015 How to Cite?
AbstractTherapeutic methods for cancer treatments using a combined prokaryotic-eukaryotic delivery and expression system for the delivery of multiple therapeutic factors via a modified tumor-targeted bacteria. A targeted bacteria-vector system elicits an inter-kingdom dual expression (IKDE) of antitumor agents, in the nucleus or cytoplasm of eukaryotic cells, with priming and maintenance of the vector in the bacterium. The therapeutic factors include small interfering RNAs, tumoricidal proteins, DNA molecules, or a combination thereof. The system provides direct killing of tumor cells and alters the tumor microenvironment by expressing anti-angiogenic factors and cytokines in intracellular and/or extracellular environments. Also provided are methods of using natural exosomes comprising cargoes obtained from the bacterially infected cells. The bacteria-vector system is useful for many types of tumor and cancer as well as recombinant vaccines. The method causes significant regression of tumor and prolongs survival of tumor-bearing mice and subject without detectable systemic toxicity.
Persistent Identifierhttp://hdl.handle.net/10722/210495

 

DC FieldValueLanguage
dc.date.accessioned2015-06-17T07:03:01Z-
dc.date.available2015-06-17T07:03:01Z-
dc.date.issued2015-
dc.identifier.citationUS Patent US 20150064215. Washington, DC: US Patent and Trademark Office (USPTO), 2015-
dc.identifier.urihttp://hdl.handle.net/10722/210495-
dc.description.abstractTherapeutic methods for cancer treatments using a combined prokaryotic-eukaryotic delivery and expression system for the delivery of multiple therapeutic factors via a modified tumor-targeted bacteria. A targeted bacteria-vector system elicits an inter-kingdom dual expression (IKDE) of antitumor agents, in the nucleus or cytoplasm of eukaryotic cells, with priming and maintenance of the vector in the bacterium. The therapeutic factors include small interfering RNAs, tumoricidal proteins, DNA molecules, or a combination thereof. The system provides direct killing of tumor cells and alters the tumor microenvironment by expressing anti-angiogenic factors and cytokines in intracellular and/or extracellular environments. Also provided are methods of using natural exosomes comprising cargoes obtained from the bacterially infected cells. The bacteria-vector system is useful for many types of tumor and cancer as well as recombinant vaccines. The method causes significant regression of tumor and prolongs survival of tumor-bearing mice and subject without detectable systemic toxicity.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documents-
dc.titleTHERAPEUTIC DELIVERY AND EXPRESSION SYSTEM, METHODS AND USES THEREOF-
dc.typePatent-
dc.identifier.authorityHUANG, JIAN-DONG=rp00451-
dc.description.naturepublished_or_final_version-
dc.contributor.inventorHUANG JIAN-DONG-
dc.contributor.inventorSHI LEI-
dc.contributor.inventorYU BIN-
patents.identifier.applicationUS 12/4019058-
patents.identifier.grantedUS 20150064215-
patents.description.assigneeUNIV HONG KONG [CN]-
patents.description.countryUnited States of America-
patents.date.granted2015-03-05-
patents.identifier.hkutechidBioch-2013-00466-1-
patents.date.application2013-09-05-
patents.date.priority2013-09-05 US 12/4019058-
patents.description.ccus-
patents.relation.familyWO 2015032165 (A1) 2015-03-12-
patents.description.kindA1-
patents.typePatent_granted-

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