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Conference Paper: New observation of early detection of venous thromboembolism by FDG PET/CT in patients with multiple myeloma

TitleNew observation of early detection of venous thromboembolism by FDG PET/CT in patients with multiple myeloma
Authors
Issue Date2014
PublisherSociety of Nuclear Medicine. The Journal's web site is located at http://jnm.snmjournals.org
Citation
The 2014 Annual Meeting of the Society of Nuclear Medicine & Molecular Imaging (SNMMI), St. Louis, MI., 7-11 June 2014. In Journal of Nuclear Medicine, 2014, v. 55 suppl., abstract no.1784 How to Cite?
AbstractObjectives: Deep vein thrombosis (DVT) and acute pulmonary embolism (PE) are two manifestations of venous thromboembolism (VTE). Early detection of VTE by FDG PET/CT allowing earlier actions may prevent further DVT, PE and potential high-risk management. This study is to investigate early FDG PET/CT evidence of VTE among cancer patients with clinical VTE diagnosis. Methods: A total of 39 whole-body FDG-PET/CT scans of 10 multiple myeloma patients with clinical VTE diagnosis according to duplex ultrasound (DUS) and/or CT angiography (CTA) were reviewed and compared to DUS and CTA. All subjects had a FDG PET/CT scan at the time of VTE diagnosis and several before and after. Results: 4 patients had DVT, 2 had PE, and 4 had both PE and DVT. In 9/10 cases, VTE associated FDG uptake was present on scans performed at the time of diagnosis as well as in all scans performed prior to DUS and CTA (up to several months). In the one case with no FDG evidence of VTE, subsequent DUS were also negative, and CTA was reassessed; PE was retrospectively considered to be a misinterpretation of posttraumatic lesions. FDG only visualized PE directly in 1 of 5 cases with CTA-confirmed PE, but all cases showed clear evidence of DVT. In 3/4 cases of upper extremity or neck vein VTE, FDG-PET/CT showed additional VTE in the lower extremities. Conclusions: FDG PET/CT appeared to be sensitive for early detection of DVT processes, even in pre-symptomatic patients. Therefore, incidental findings suggestive of VTE in cancer patients should be reported and considered by clinicians. We suggest when there is no FDG evidence of DVT in patients suspected of PE, other possibilities should be investigated.
Persistent Identifierhttp://hdl.handle.net/10722/210266
ISSN
2015 Impact Factor: 5.849
2015 SCImago Journal Rankings: 2.541

 

DC FieldValueLanguage
dc.contributor.authorZhu, HJ-
dc.contributor.authorHess, S-
dc.contributor.authorSalavati, A-
dc.contributor.authorGoris, M-
dc.contributor.authorAlavi, A-
dc.date.accessioned2015-06-03T01:47:03Z-
dc.date.available2015-06-03T01:47:03Z-
dc.date.issued2014-
dc.identifier.citationThe 2014 Annual Meeting of the Society of Nuclear Medicine & Molecular Imaging (SNMMI), St. Louis, MI., 7-11 June 2014. In Journal of Nuclear Medicine, 2014, v. 55 suppl., abstract no.1784-
dc.identifier.issn0161-5505-
dc.identifier.urihttp://hdl.handle.net/10722/210266-
dc.description.abstractObjectives: Deep vein thrombosis (DVT) and acute pulmonary embolism (PE) are two manifestations of venous thromboembolism (VTE). Early detection of VTE by FDG PET/CT allowing earlier actions may prevent further DVT, PE and potential high-risk management. This study is to investigate early FDG PET/CT evidence of VTE among cancer patients with clinical VTE diagnosis. Methods: A total of 39 whole-body FDG-PET/CT scans of 10 multiple myeloma patients with clinical VTE diagnosis according to duplex ultrasound (DUS) and/or CT angiography (CTA) were reviewed and compared to DUS and CTA. All subjects had a FDG PET/CT scan at the time of VTE diagnosis and several before and after. Results: 4 patients had DVT, 2 had PE, and 4 had both PE and DVT. In 9/10 cases, VTE associated FDG uptake was present on scans performed at the time of diagnosis as well as in all scans performed prior to DUS and CTA (up to several months). In the one case with no FDG evidence of VTE, subsequent DUS were also negative, and CTA was reassessed; PE was retrospectively considered to be a misinterpretation of posttraumatic lesions. FDG only visualized PE directly in 1 of 5 cases with CTA-confirmed PE, but all cases showed clear evidence of DVT. In 3/4 cases of upper extremity or neck vein VTE, FDG-PET/CT showed additional VTE in the lower extremities. Conclusions: FDG PET/CT appeared to be sensitive for early detection of DVT processes, even in pre-symptomatic patients. Therefore, incidental findings suggestive of VTE in cancer patients should be reported and considered by clinicians. We suggest when there is no FDG evidence of DVT in patients suspected of PE, other possibilities should be investigated.-
dc.languageeng-
dc.publisherSociety of Nuclear Medicine. The Journal's web site is located at http://jnm.snmjournals.org-
dc.relation.ispartofJournal of Nuclear Medicine-
dc.titleNew observation of early detection of venous thromboembolism by FDG PET/CT in patients with multiple myeloma-
dc.typeConference_Paper-
dc.identifier.emailZhu, HJ: junezhu@hku.hk-
dc.identifier.authorityZhu, HJ=rp01909-
dc.identifier.volume55-
dc.identifier.issuesuppl.-
dc.publisher.placeUnited States-

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