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Article: Airway Inflammation, exhaled nitric oxide, and severity of asthma in patients with Western red cedar asthma

TitleAirway Inflammation, exhaled nitric oxide, and severity of asthma in patients with Western red cedar asthma
Authors
Issue Date1999
PublisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.org
Citation
American Journal of Respiratory and Critical Care Medicine, 1999, v. 159 n. 5, p. 1434-1438 How to Cite?
AbstractExamination of induced sputum and measurement of exhaled NO have been advocated as noninvasive methods of assessing the degree of airway inflammation. In this study, we performed follow-up evaluation on 71 subjects with asthma caused by exposure to Western red cedar; 50 subjects had left exposure, whereas the rest continued to work in the same job. Spirometry, methacholine challenge tests, exhaled nitric oxide, and sputum induction were carried out. Of the 50 subjects who left exposure, 12 had no respiratory impairment according to the American Throacic Society guidelines for assessing respiratory impairment in patients with asthma, 17 belonged to Class 1, 12 to Class 2, five to Class 3, and four to Class 4. The percentage of eosinophils in induced sputum showed a significant inverse relationship with FEV1 (r = − 0.46, p < 0.001), and a significant positive correlation with levels of exhaled NO (r = 0.42, p < 0.001) and with the class of respiratory impairment (r = 0.52, p < 0.001). Mean percent eosinophils were 1.5 for impairment Class 0, 2.2 for Class 1, 1.7 for Class 2, 6.8 for Class 3, and 16.3 for Class 4. No relationship was found between the levels of exhaled NO and the functional parameters as well as the impairment class. NO levels in ppb were 21 for impairment Class 0, 30 for Class 1, 22 for Class 2, 26 for Class 3, and 49 for Class 4. This study also provides objective evidence that airway inflammation, as indicated by induced sputum, corroborates the rating of respiratory impairment in patients with asthma.
Persistent Identifierhttp://hdl.handle.net/10722/210227
ISSN
2015 Impact Factor: 13.118
2015 SCImago Journal Rankings: 5.832

 

DC FieldValueLanguage
dc.contributor.authorChan-Yeung, M-
dc.contributor.authorObata, H-
dc.contributor.authorDittirck, M-
dc.contributor.authorChan, H-
dc.contributor.authorAbboud, R-
dc.date.accessioned2015-05-29T02:36:33Z-
dc.date.available2015-05-29T02:36:33Z-
dc.date.issued1999-
dc.identifier.citationAmerican Journal of Respiratory and Critical Care Medicine, 1999, v. 159 n. 5, p. 1434-1438-
dc.identifier.issn1073-449X-
dc.identifier.urihttp://hdl.handle.net/10722/210227-
dc.description.abstractExamination of induced sputum and measurement of exhaled NO have been advocated as noninvasive methods of assessing the degree of airway inflammation. In this study, we performed follow-up evaluation on 71 subjects with asthma caused by exposure to Western red cedar; 50 subjects had left exposure, whereas the rest continued to work in the same job. Spirometry, methacholine challenge tests, exhaled nitric oxide, and sputum induction were carried out. Of the 50 subjects who left exposure, 12 had no respiratory impairment according to the American Throacic Society guidelines for assessing respiratory impairment in patients with asthma, 17 belonged to Class 1, 12 to Class 2, five to Class 3, and four to Class 4. The percentage of eosinophils in induced sputum showed a significant inverse relationship with FEV1 (r = − 0.46, p < 0.001), and a significant positive correlation with levels of exhaled NO (r = 0.42, p < 0.001) and with the class of respiratory impairment (r = 0.52, p < 0.001). Mean percent eosinophils were 1.5 for impairment Class 0, 2.2 for Class 1, 1.7 for Class 2, 6.8 for Class 3, and 16.3 for Class 4. No relationship was found between the levels of exhaled NO and the functional parameters as well as the impairment class. NO levels in ppb were 21 for impairment Class 0, 30 for Class 1, 22 for Class 2, 26 for Class 3, and 49 for Class 4. This study also provides objective evidence that airway inflammation, as indicated by induced sputum, corroborates the rating of respiratory impairment in patients with asthma.-
dc.languageeng-
dc.publisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.org-
dc.relation.ispartofAmerican Journal of Respiratory and Critical Care Medicine-
dc.titleAirway Inflammation, exhaled nitric oxide, and severity of asthma in patients with Western red cedar asthma-
dc.typeArticle-
dc.identifier.emailChan-Yeung, M: mmwchan@hku.hk-
dc.identifier.doi10.1164/ajrccm.159.5.9807007-
dc.identifier.hkuros42759-
dc.identifier.volume159-
dc.identifier.issue5-
dc.identifier.spage1434-
dc.identifier.epage1438-
dc.publisher.placeUnited States-

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