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Conference Paper: Association of Blood Pressure and Obesity with a Single Nucleotide Polymorphism at 17p12

TitleAssociation of Blood Pressure and Obesity with a Single Nucleotide Polymorphism at 17p12
Authors
KeywordsHypertension
Obesity
Single Nucleotide Polymorphism
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.nature.com/ajh/index.html
Citation
American Journal of Hypertension, 2005, v. 18 n. suppl. 4, p. 79A How to Cite?
AbstractHypertension is related to overweight and the metabolic syndrome. We have previously studied the microsatellite marker D17S1303 at a quantitative trait locus for abdominal obesity-metabolic syndrome (AOMS1) at 17p12 on chromosome 17, which has also been linked to hypertension in a genome scan in Chinese. We found that it was associated with blood pressure and body mass index. Therefore, we studied 5 single nucleotide polymorphisms (SNP) within 3kb from D17S1303 in 88 hypertensive subjects (49 men, 39 women, age 53±13) and 90 normotensive controls (47 men, 43 women, age 54±13) using the Sequenom genotyping platform. Allelic frequencies in these Chinese subjects differed from those reported for Caucasians. Three SNPs (rs11656507, rs1357926, rs852321) were homozygous in our subjects. The allelic frequencies of rs852321 and rs852320 did not differ between hypertensive and normotensive subjects (p=0.6 and p=0.2 respectively). However, rs852320 genotypes correlated with diastolic blood pressure (r=0.19, p =0.01), percentage body fat (r=0.17, p=0.04) and LDL-cholesterol (r=0.17, p=0.03). The diastolic blood pressures in subjects with the TT, TG and GG genotypes were 78.2±1.1, 81.8±1.9, and 93.2±4.9 mmHgH respectively (p=0.007). Our results provide further evidence that there is a gene, as yet unidentified, predisposing to hypertension and the metabolic syndrome at 17p12.
Persistent Identifierhttp://hdl.handle.net/10722/210224
ISSN
2015 Impact Factor: 3.182
2015 SCImago Journal Rankings: 1.397

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMY-
dc.contributor.authorLeung, YH-
dc.contributor.authorMan, YB-
dc.contributor.authorWong, LYF-
dc.contributor.authorLau, CP-
dc.date.accessioned2015-05-28T08:25:22Z-
dc.date.available2015-05-28T08:25:22Z-
dc.date.issued2005-
dc.identifier.citationAmerican Journal of Hypertension, 2005, v. 18 n. suppl. 4, p. 79A-
dc.identifier.issn0895-7061-
dc.identifier.urihttp://hdl.handle.net/10722/210224-
dc.description.abstractHypertension is related to overweight and the metabolic syndrome. We have previously studied the microsatellite marker D17S1303 at a quantitative trait locus for abdominal obesity-metabolic syndrome (AOMS1) at 17p12 on chromosome 17, which has also been linked to hypertension in a genome scan in Chinese. We found that it was associated with blood pressure and body mass index. Therefore, we studied 5 single nucleotide polymorphisms (SNP) within 3kb from D17S1303 in 88 hypertensive subjects (49 men, 39 women, age 53±13) and 90 normotensive controls (47 men, 43 women, age 54±13) using the Sequenom genotyping platform. Allelic frequencies in these Chinese subjects differed from those reported for Caucasians. Three SNPs (rs11656507, rs1357926, rs852321) were homozygous in our subjects. The allelic frequencies of rs852321 and rs852320 did not differ between hypertensive and normotensive subjects (p=0.6 and p=0.2 respectively). However, rs852320 genotypes correlated with diastolic blood pressure (r=0.19, p =0.01), percentage body fat (r=0.17, p=0.04) and LDL-cholesterol (r=0.17, p=0.03). The diastolic blood pressures in subjects with the TT, TG and GG genotypes were 78.2±1.1, 81.8±1.9, and 93.2±4.9 mmHgH respectively (p=0.007). Our results provide further evidence that there is a gene, as yet unidentified, predisposing to hypertension and the metabolic syndrome at 17p12.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.nature.com/ajh/index.html-
dc.relation.ispartofAmerican Journal of Hypertension-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in [Journal title]. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#-
dc.subjectHypertension-
dc.subjectObesity-
dc.subjectSingle Nucleotide Polymorphism-
dc.titleAssociation of Blood Pressure and Obesity with a Single Nucleotide Polymorphism at 17p12-
dc.typeConference_Paper-
dc.identifier.emailCheung, BMY: mycheung@hku.hk-
dc.identifier.emailLeung, YH: yhleung@hkucc.hku.hk-
dc.identifier.emailWong, LYF: lyfwong@hkucc.hku.hk-
dc.identifier.emailLau, CP: cplau@hku.hk-
dc.identifier.doi10.1016/j.amjhyper.2005.03.219-
dc.identifier.hkuros110029-
dc.identifier.volume18-
dc.identifier.issuesuppl. 4-
dc.identifier.spage79A-
dc.identifier.epage79A-
dc.publisher.placeUnited States-

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