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Article: A Follow-up Study of Atypical Squamous Cells in Gynecologic Cytology Using Conventional Papanicolaou Smears and Liquid-Based Preparations: The Impact of the Bethesda System 2001

TitleA Follow-up Study of Atypical Squamous Cells in Gynecologic Cytology Using Conventional Papanicolaou Smears and Liquid-Based Preparations: The Impact of the Bethesda System 2001
Authors
KeywordsAtypical squamous cells
Squamous intraepithelial lesion
Gynecologic cytology
Bethesda System
Issue Date2007
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal of Clinical Pathology, 2007, v. 127 n. 4, p. 548-555 How to Cite?
AbstractWe evaluated the impact of the Bethesda System (TBS) 2001 in cytology reporting of atypical squamous cells (ASC) when using conventional Pap smears and liquid-based cytology preparations (LBC). Follow-up information for all ASC cases encountered in Queen Mary Hospital, Hong Kong, China, from July 2000 to June 2004 (using TBS 1991 in the first 2-year period and TBS 2001 in the second) was analyzed. Among 4,089 ASC cases studied, more than 50% had negative follow-up; this percentage was lower with TBS 2001. The percentage of ASC cases with a low-grade cervical intraepithelial neoplasia (CIN) end point was higher with TBS 2001, especially after application of LBC. There was also a decreasing trend of having this low-grade CIN end point with advancing age. Most clinically significant outcomes occurred after 6 months and before 1 year post-ASC diagnosis. With TBS 2001, more than 50% of ASC, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) were associated with high-grade CIN on follow-up. TBS 2001 improves the positive predictive value of ASC for clinically significant lesions. Introduction of dichotomous subcategorization of ASC is relevant, with ASC-H associated with a much higher risk of subsequent high-grade squamous lesions.
Persistent Identifierhttp://hdl.handle.net/10722/210053
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.129

 

DC FieldValueLanguage
dc.contributor.authorLee, CYK-
dc.contributor.authorNg, WK-
dc.date.accessioned2015-05-21T07:16:41Z-
dc.date.available2015-05-21T07:16:41Z-
dc.date.issued2007-
dc.identifier.citationAmerican Journal of Clinical Pathology, 2007, v. 127 n. 4, p. 548-555-
dc.identifier.issn0002-9173-
dc.identifier.urihttp://hdl.handle.net/10722/210053-
dc.description.abstractWe evaluated the impact of the Bethesda System (TBS) 2001 in cytology reporting of atypical squamous cells (ASC) when using conventional Pap smears and liquid-based cytology preparations (LBC). Follow-up information for all ASC cases encountered in Queen Mary Hospital, Hong Kong, China, from July 2000 to June 2004 (using TBS 1991 in the first 2-year period and TBS 2001 in the second) was analyzed. Among 4,089 ASC cases studied, more than 50% had negative follow-up; this percentage was lower with TBS 2001. The percentage of ASC cases with a low-grade cervical intraepithelial neoplasia (CIN) end point was higher with TBS 2001, especially after application of LBC. There was also a decreasing trend of having this low-grade CIN end point with advancing age. Most clinically significant outcomes occurred after 6 months and before 1 year post-ASC diagnosis. With TBS 2001, more than 50% of ASC, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) were associated with high-grade CIN on follow-up. TBS 2001 improves the positive predictive value of ASC for clinically significant lesions. Introduction of dichotomous subcategorization of ASC is relevant, with ASC-H associated with a much higher risk of subsequent high-grade squamous lesions.-
dc.languageeng-
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com-
dc.relation.ispartofAmerican Journal of Clinical Pathology-
dc.subjectAtypical squamous cells-
dc.subjectSquamous intraepithelial lesion-
dc.subjectGynecologic cytology-
dc.subjectBethesda System-
dc.titleA Follow-up Study of Atypical Squamous Cells in Gynecologic Cytology Using Conventional Papanicolaou Smears and Liquid-Based Preparations: The Impact of the Bethesda System 2001-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1309/21U34K8YW053F21E-
dc.identifier.pmid17369129-
dc.identifier.hkuros139095-
dc.identifier.volume127-
dc.identifier.issue4-
dc.identifier.spage548-
dc.identifier.epage555-
dc.publisher.placeUnited States-

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