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Article: Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children

TitleMultivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children
Authors
Issue Date2015
Citation
Epidemiology and Infection, 2015, v. 143 n. 3, p. 540-549 How to Cite?
AbstractWe examined factors affecting the immunogenicity of trivalent inactivated influenza vaccination (TIV) in children using the antibody titres of children participating in a Hong Kong community-based study. Antibody titres of strains included in the 2009-2010 northern hemisphere TIV [seasonal A(H1N1), seasonal A(H3N2) and B (Victoria lineage)] and those not included in the TIV [2009 pandemic A(H1N1) and B (Yamagata lineage)] were measured by haemagglutination inhibition immediately before and 1 month after vaccination. Multivariate regression models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following vaccination. Statistically significant rises in geometric mean antibody titres were observed against all strains, with a wide variety of standard deviations and correlations in rises observed, with the influenza type B antibodies showing more variability than the type A antibodies. The dynamics of antibody titres after vaccination can be used in more complex models of antibody dynamics in populations.
Persistent Identifierhttp://hdl.handle.net/10722/209411

 

DC FieldValueLanguage
dc.contributor.authorFreeman, Gen_US
dc.contributor.authorNg, Sen_US
dc.contributor.authorPerera, RAPMen_US
dc.contributor.authorFang, Jen_US
dc.contributor.authorIp, DKMen_US
dc.contributor.authorLeung, GMen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorCowling, BJen_US
dc.date.accessioned2015-04-17T05:15:47Z-
dc.date.available2015-04-17T05:15:47Z-
dc.date.issued2015en_US
dc.identifier.citationEpidemiology and Infection, 2015, v. 143 n. 3, p. 540-549en_US
dc.identifier.urihttp://hdl.handle.net/10722/209411-
dc.description.abstractWe examined factors affecting the immunogenicity of trivalent inactivated influenza vaccination (TIV) in children using the antibody titres of children participating in a Hong Kong community-based study. Antibody titres of strains included in the 2009-2010 northern hemisphere TIV [seasonal A(H1N1), seasonal A(H3N2) and B (Victoria lineage)] and those not included in the TIV [2009 pandemic A(H1N1) and B (Yamagata lineage)] were measured by haemagglutination inhibition immediately before and 1 month after vaccination. Multivariate regression models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following vaccination. Statistically significant rises in geometric mean antibody titres were observed against all strains, with a wide variety of standard deviations and correlations in rises observed, with the influenza type B antibodies showing more variability than the type A antibodies. The dynamics of antibody titres after vaccination can be used in more complex models of antibody dynamics in populations.en_US
dc.languageengen_US
dc.relation.ispartofEpidemiology and Infectionen_US
dc.titleMultivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age childrenen_US
dc.typeArticleen_US
dc.identifier.emailPerera, RAPM: mahenp@hku.hken_US
dc.identifier.emailFang, J: vickyf@hku.hken_US
dc.identifier.emailIp, DKM: dkmip@hku.hken_US
dc.identifier.emailLeung, GM: gmleung@hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.emailCowling, BJ: bcowling@hku.hken_US
dc.identifier.authorityFreeman, G=rp01694en_US
dc.identifier.authorityIp, DKM=rp00256en_US
dc.identifier.authorityLeung, GM=rp00460en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.authorityCowling, BJ=rp01326en_US
dc.identifier.doi10.1017/S0950268814000855en_US
dc.identifier.hkuros242824en_US
dc.identifier.volume143en_US
dc.identifier.issue3en_US
dc.identifier.spage540en_US
dc.identifier.epage549en_US

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