File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Sub-regional nucleus basalis of Meynert pathology in Lewy body disorders

TitleSub-regional nucleus basalis of Meynert pathology in Lewy body disorders
Authors
KeywordsMedical sciences
Psychiatry and neurology
Issue Date2015
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NAN
Citation
The 116th Meeting of the British Neuropathological Society (BNS 2015), London, UK., 4-6 March 2015. In Neuropathology and Applied Neurobiology, 2015, v. 41 suppl. 1, p. 11-12, abstract no. O07 How to Cite?
AbstractINTRODUCTION: Cortical acetylcholine is essential for normal cognitive functioning and its innervation originates from the nucleus basalis of Meynert (nbM). Retrograde tracer studies on non-human primates have shown a topographic innervation from different sub-regions of the nbM with the anterior portion providing afferents to the frontal and medial cortical regions; intermediate nbM to the lateral cortical regions; and posterior division innervating the temporal polar region. In Alzheimer’s disease (AD), the posterior nbM has shown the greatest degree of neuronal loss. However, detailed sub-regional analysis of the nbM has not been performed on Lewy body disorders (LBD). With functional imaging studies highlighting the difference in cortical cholinergic deficits between AD and LBD, we hypothesise a differential susceptibility to pathology in LBD. MATERIAL AND METHODS: Basal forebrain tissues from 43 Parkinson’s disease (PD). 20 PD with mild cognitive impairment (PD-MCI), 61 PD with dementia (PDD), 8 Dementia with Lewy Bodies (DLB) and 9 age-matched controls were obtained from the Parkinson’s UK Tissue Bank. Tissues were stained with H&E for the determi- nation of nbM sub-regions, and immunohistochemistry, with choline acetyltransferase (ChAT) antibodies, for the quantification of cholinergic neurons. RESULTS: A graded decrease of ChAT-positive neuronal density was observed as PD cognitive disability increased. In PDD, all nbM sub-regions appeared to be equally affected, whereas the degree of neuronal loss in PD without cognitive deficit was most severe in the posterior nbM sub-region. No significant difference between sub-regional cell loss in PDD and DLB was observed. CONCLUSION: Our results show that sub-regional pathology exists in different LBD. Further work is now needed to determine if this corresponds to the findings from recent functional imaging studies.
DescriptionOral Presentation: First scientific session – Neuropathology of Neurogeneration: no. O07
This journal suppl. entitled: Special Issue: Proceedings of the 116th Meeting of the British Neuropathological Society, Institute of Child Health, London, UK, 4–6 March 2015
Persistent Identifierhttp://hdl.handle.net/10722/209259
ISSN
2015 Impact Factor: 4.483
2015 SCImago Journal Rankings: 1.859

 

DC FieldValueLanguage
dc.contributor.authorLiu, AKL-
dc.contributor.authorChang, RCC-
dc.contributor.authorPearce, RKB-
dc.contributor.authorGentleman, SM-
dc.date.accessioned2015-04-14T07:17:52Z-
dc.date.available2015-04-14T07:17:52Z-
dc.date.issued2015-
dc.identifier.citationThe 116th Meeting of the British Neuropathological Society (BNS 2015), London, UK., 4-6 March 2015. In Neuropathology and Applied Neurobiology, 2015, v. 41 suppl. 1, p. 11-12, abstract no. O07-
dc.identifier.issn0305-1846-
dc.identifier.urihttp://hdl.handle.net/10722/209259-
dc.descriptionOral Presentation: First scientific session – Neuropathology of Neurogeneration: no. O07-
dc.descriptionThis journal suppl. entitled: Special Issue: Proceedings of the 116th Meeting of the British Neuropathological Society, Institute of Child Health, London, UK, 4–6 March 2015-
dc.description.abstractINTRODUCTION: Cortical acetylcholine is essential for normal cognitive functioning and its innervation originates from the nucleus basalis of Meynert (nbM). Retrograde tracer studies on non-human primates have shown a topographic innervation from different sub-regions of the nbM with the anterior portion providing afferents to the frontal and medial cortical regions; intermediate nbM to the lateral cortical regions; and posterior division innervating the temporal polar region. In Alzheimer’s disease (AD), the posterior nbM has shown the greatest degree of neuronal loss. However, detailed sub-regional analysis of the nbM has not been performed on Lewy body disorders (LBD). With functional imaging studies highlighting the difference in cortical cholinergic deficits between AD and LBD, we hypothesise a differential susceptibility to pathology in LBD. MATERIAL AND METHODS: Basal forebrain tissues from 43 Parkinson’s disease (PD). 20 PD with mild cognitive impairment (PD-MCI), 61 PD with dementia (PDD), 8 Dementia with Lewy Bodies (DLB) and 9 age-matched controls were obtained from the Parkinson’s UK Tissue Bank. Tissues were stained with H&E for the determi- nation of nbM sub-regions, and immunohistochemistry, with choline acetyltransferase (ChAT) antibodies, for the quantification of cholinergic neurons. RESULTS: A graded decrease of ChAT-positive neuronal density was observed as PD cognitive disability increased. In PDD, all nbM sub-regions appeared to be equally affected, whereas the degree of neuronal loss in PD without cognitive deficit was most severe in the posterior nbM sub-region. No significant difference between sub-regional cell loss in PDD and DLB was observed. CONCLUSION: Our results show that sub-regional pathology exists in different LBD. Further work is now needed to determine if this corresponds to the findings from recent functional imaging studies.-
dc.languageeng-
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NAN-
dc.relation.ispartofNeuropathology and Applied Neurobiology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.rightsAuthor holds the copyright-
dc.subjectMedical sciences-
dc.subjectPsychiatry and neurology-
dc.titleSub-regional nucleus basalis of Meynert pathology in Lewy body disorders-
dc.typeConference_Paper-
dc.identifier.emailChang, RCC: rccchang@hku.hk-
dc.identifier.authorityChang, RCC=rp00470-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/nan.12223-
dc.identifier.hkuros242901-
dc.identifier.volume41-
dc.identifier.issuesuppl. 1-
dc.identifier.spage11, abstract no. O07-
dc.identifier.epage12-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats