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Article: Traffic-related air pollution and incident asthma in a high-risk birth cohort

TitleTraffic-related air pollution and incident asthma in a high-risk birth cohort
Authors
Issue Date2011
PublisherBMJ Publishing Group. The Journal's web site is located at http://www.occenvmed.com
Citation
Occupational and Environmental Medicine, 2011, v. 68 n. 4, p. 291-295 How to Cite?
AbstractAbstract OBJECTIVES: The risk of incident asthma and bronchial hyper-reactivity associated with early life exposure to traffic-related air pollution has not been fully elucidated. We aimed to evaluate the hypothesis that the risk of new onset asthma is positively associated with early exposure to traffic-related air pollution in a well-characterised high-risk birth cohort. METHODS: Infants at high-risk for asthma were recruited for an intervention study. Birth year exposures to NO, NO(2), black carbon and PM(2.5) were estimated by land use regression. At 7 years of age, asthma was assessed by a paediatric allergist and bronchial hyper-reactivity was measured by methacholine challenge. Associations between exposures and outcomes were analysed by stepwise multiple logistic regression, adjusted for potential confounding variables. RESULTS: Exposure estimates were available for 184 children; 23 were diagnosed with asthma and 68 with bronchial hyper-reactivity. The IQR (4.1 μg/m(3)) of birth year PM(2.5) was associated with a significantly increased risk of asthma (OR 3.1, 95% CI 1.3 to 7.4) and with a trend to increased risk of bronchial hyper-reactivity. Similar findings were noted in association with NO and NO(2), while black carbon did not appear to confer increased risk. CONCLUSION: Modest elevations in exposure to some traffic-related air pollutants during the year of birth are associated with new onset asthma assessed at age 7. That significant associations were revealed in spite of a limited sample size emphasises the strengths of a high-risk birth cohort model, along with individual air pollution exposure estimates and well-characterised data on covariates and outcomes.
Persistent Identifierhttp://hdl.handle.net/10722/209244
ISSN
2015 Impact Factor: 3.745
2015 SCImago Journal Rankings: 1.597

 

DC FieldValueLanguage
dc.contributor.authorCarlsten, C-
dc.contributor.authorDybuncio, A-
dc.contributor.authorBecker, A-
dc.contributor.authorChan, MMW-
dc.contributor.authorBrauer, M-
dc.date.accessioned2015-04-14T04:04:13Z-
dc.date.available2015-04-14T04:04:13Z-
dc.date.issued2011-
dc.identifier.citationOccupational and Environmental Medicine, 2011, v. 68 n. 4, p. 291-295-
dc.identifier.issn1351-0711-
dc.identifier.urihttp://hdl.handle.net/10722/209244-
dc.description.abstractAbstract OBJECTIVES: The risk of incident asthma and bronchial hyper-reactivity associated with early life exposure to traffic-related air pollution has not been fully elucidated. We aimed to evaluate the hypothesis that the risk of new onset asthma is positively associated with early exposure to traffic-related air pollution in a well-characterised high-risk birth cohort. METHODS: Infants at high-risk for asthma were recruited for an intervention study. Birth year exposures to NO, NO(2), black carbon and PM(2.5) were estimated by land use regression. At 7 years of age, asthma was assessed by a paediatric allergist and bronchial hyper-reactivity was measured by methacholine challenge. Associations between exposures and outcomes were analysed by stepwise multiple logistic regression, adjusted for potential confounding variables. RESULTS: Exposure estimates were available for 184 children; 23 were diagnosed with asthma and 68 with bronchial hyper-reactivity. The IQR (4.1 μg/m(3)) of birth year PM(2.5) was associated with a significantly increased risk of asthma (OR 3.1, 95% CI 1.3 to 7.4) and with a trend to increased risk of bronchial hyper-reactivity. Similar findings were noted in association with NO and NO(2), while black carbon did not appear to confer increased risk. CONCLUSION: Modest elevations in exposure to some traffic-related air pollutants during the year of birth are associated with new onset asthma assessed at age 7. That significant associations were revealed in spite of a limited sample size emphasises the strengths of a high-risk birth cohort model, along with individual air pollution exposure estimates and well-characterised data on covariates and outcomes.-
dc.languageeng-
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://www.occenvmed.com-
dc.relation.ispartofOccupational and Environmental Medicine-
dc.rightsOccupational and Environmental Medicine. Copyright © BMJ Publishing Group.-
dc.rightsThe following statements must accompany the articles posted on the Contributor(s)’s and/or his/her institution’s website: Locked and research funded articles acknowledgement: This article has been accepted for publication in [Contributor, please insert journal name]. The definitive copyedited, typeset version [Contributor please insert complete citation information when available] is available online at: www. [Contributor please insert as applicable] .com Unlocked article acknowledgement: This article has been accepted for publication in [Contributor please insert full citation] following peer review and can also be viewed on the journal’s website at www. [Contributor please insert as applicable] .com-
dc.titleTraffic-related air pollution and incident asthma in a high-risk birth cohort-
dc.typeArticle-
dc.identifier.emailChan, MMW: mmwchan@hku.hk-
dc.identifier.doi10.1136/oem.2010.055152-
dc.identifier.pmid20952556-
dc.identifier.hkuros196611-
dc.identifier.volume68-
dc.identifier.issue4-
dc.identifier.spage291-
dc.identifier.epage295-
dc.publisher.placeUnited Kingdom-

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