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Article: Association between endotoxin and mite allergen exposure with asthma and specific sensitization at age 7 in high-risk children

TitleAssociation between endotoxin and mite allergen exposure with asthma and specific sensitization at age 7 in high-risk children
Authors
Issue Date2011
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PAI
Citation
Pediatric Allergy and Immunology, 2011, v. 22 n. 3, p. 320-326 How to Cite?
AbstractThe role of endotoxin and house dust mite allergen (HDM) in allergen sensitization and asthma is unclear. The timeframe of exposure and asthma assessment appears critical. We aimed to determine, in children at 7 yr of age, the association between current exposure to endotoxin and HDM and risks of recurrent wheeze, paediatric allergist diagnosed asthma and allergen sensitization. Three hundred and eighty children who had an increased risk of asthma because of family background were assessed at age 7 yr by a questionnaire-standardized interview, allergen skin testing and clinical examination by a paediatric allergist. Dust samples were collected from their homes and analysed for levels of endotoxin and HDM (Der p 1 and Der f 1). Levels of endotoxin in dust samples were associated with protection from paediatric allergist diagnosed asthma with inhaled steroid use (OR 0.69, 95% CI 0.53-0.91) and specific sensitization to dog allergen (OR 0.68, 95% CI 0.51-0.90) at the age of 7 yr; both endotoxin and HDM were associated with decreased risk of sensitization to dog allergen. In high-risk children at age 7, endotoxin levels were associated with decreased sensitization to dog, as well as with decreased asthma.
Persistent Identifierhttp://hdl.handle.net/10722/209240
ISSN
2015 Impact Factor: 3.947
2015 SCImago Journal Rankings: 1.689

 

DC FieldValueLanguage
dc.contributor.authorCarlsten, C-
dc.contributor.authorFerguson, A-
dc.contributor.authorDimich-Ward, H-
dc.contributor.authorChan, H-
dc.contributor.authorDyBuncio, A-
dc.contributor.authorRousseau, R-
dc.contributor.authorBecker, A-
dc.contributor.authorChan, MMW-
dc.date.accessioned2015-04-14T03:50:58Z-
dc.date.available2015-04-14T03:50:58Z-
dc.date.issued2011-
dc.identifier.citationPediatric Allergy and Immunology, 2011, v. 22 n. 3, p. 320-326-
dc.identifier.issn0905-6157-
dc.identifier.urihttp://hdl.handle.net/10722/209240-
dc.description.abstractThe role of endotoxin and house dust mite allergen (HDM) in allergen sensitization and asthma is unclear. The timeframe of exposure and asthma assessment appears critical. We aimed to determine, in children at 7 yr of age, the association between current exposure to endotoxin and HDM and risks of recurrent wheeze, paediatric allergist diagnosed asthma and allergen sensitization. Three hundred and eighty children who had an increased risk of asthma because of family background were assessed at age 7 yr by a questionnaire-standardized interview, allergen skin testing and clinical examination by a paediatric allergist. Dust samples were collected from their homes and analysed for levels of endotoxin and HDM (Der p 1 and Der f 1). Levels of endotoxin in dust samples were associated with protection from paediatric allergist diagnosed asthma with inhaled steroid use (OR 0.69, 95% CI 0.53-0.91) and specific sensitization to dog allergen (OR 0.68, 95% CI 0.51-0.90) at the age of 7 yr; both endotoxin and HDM were associated with decreased risk of sensitization to dog allergen. In high-risk children at age 7, endotoxin levels were associated with decreased sensitization to dog, as well as with decreased asthma.-
dc.languageeng-
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PAI-
dc.relation.ispartofPediatric Allergy and Immunology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titleAssociation between endotoxin and mite allergen exposure with asthma and specific sensitization at age 7 in high-risk children-
dc.typeArticle-
dc.identifier.emailChan, MMW: mmwchan@hku.hk-
dc.identifier.doi10.1111/j.1399-3038.2010.01123.x-
dc.identifier.pmid21255084-
dc.identifier.hkuros196605-
dc.identifier.volume22-
dc.identifier.issue3-
dc.identifier.spage320-
dc.identifier.epage326-
dc.publisher.placeDenmark-

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