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Article: Developing a Molecular Roadmap of Drug-Food Interactions

TitleDeveloping a Molecular Roadmap of Drug-Food Interactions
Authors
Issue Date2015
PublisherPublic Library of Science. The Journal's web site is located at http://www.ploscompbiol.org/
Citation
PLoS Computational Biology, 2015, v. 11 n. 2, p. e1004048 How to Cite?
AbstractRecent research has demonstrated that consumption of food -especially fruits and vegetables- can alter the effects of drugs by interfering either with their pharmacokinetic or pharmacodynamic processes. Despite the recognition of such drug-food associations as an important element for successful therapeutic interventions, a systematic approach for identifying, predicting and preventing potential interactions between food and marketed or novel drugs is not yet available. The overall objective of this work was to sketch a comprehensive picture of the interference of ∼ 4,000 dietary components present in ∼1800 plant-based foods with the pharmacokinetics and pharmacodynamics processes of medicine, with the purpose of elucidating the molecular mechanisms involved. By employing a systems chemical biology approach that integrates data from the scientific literature and online databases, we gained a global view of the associations between diet and dietary molecules with drug targets, metabolic enzymes, drug transporters and carriers currently deposited in DrugBank. Moreover, we identified disease areas and drug targets that are most prone to the negative effects of drug-food interactions, showcasing a platform for making recommendations in relation to foods that should be avoided under certain medications. Lastly, by investigating the correlation of gene expression signatures of foods and drugs we were able to generate a completely novel drug-diet interactome map.
Persistent Identifierhttp://hdl.handle.net/10722/208753
ISSN
2015 Impact Factor: 4.587
2015 SCImago Journal Rankings: 3.405
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJensen, JKen_US
dc.contributor.authorNI, Yen_US
dc.contributor.authorPanagiotou, Ien_US
dc.contributor.authorKouskoumevakaki, IKen_US
dc.date.accessioned2015-03-18T09:09:59Z-
dc.date.available2015-03-18T09:09:59Z-
dc.date.issued2015-
dc.identifier.citationPLoS Computational Biology, 2015, v. 11 n. 2, p. e1004048-
dc.identifier.issn1553-734X-
dc.identifier.urihttp://hdl.handle.net/10722/208753-
dc.description.abstractRecent research has demonstrated that consumption of food -especially fruits and vegetables- can alter the effects of drugs by interfering either with their pharmacokinetic or pharmacodynamic processes. Despite the recognition of such drug-food associations as an important element for successful therapeutic interventions, a systematic approach for identifying, predicting and preventing potential interactions between food and marketed or novel drugs is not yet available. The overall objective of this work was to sketch a comprehensive picture of the interference of ∼ 4,000 dietary components present in ∼1800 plant-based foods with the pharmacokinetics and pharmacodynamics processes of medicine, with the purpose of elucidating the molecular mechanisms involved. By employing a systems chemical biology approach that integrates data from the scientific literature and online databases, we gained a global view of the associations between diet and dietary molecules with drug targets, metabolic enzymes, drug transporters and carriers currently deposited in DrugBank. Moreover, we identified disease areas and drug targets that are most prone to the negative effects of drug-food interactions, showcasing a platform for making recommendations in relation to foods that should be avoided under certain medications. Lastly, by investigating the correlation of gene expression signatures of foods and drugs we were able to generate a completely novel drug-diet interactome map.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.ploscompbiol.org/-
dc.relation.ispartofPLoS Computational Biology-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleDeveloping a Molecular Roadmap of Drug-Food Interactions-
dc.typeArticle-
dc.identifier.emailPanagiotou, I: gipa@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pcbi.1004048-
dc.identifier.pmid25668218-
dc.identifier.pmcidPMC4323218-
dc.identifier.hkuros242612-
dc.identifier.volume11-
dc.identifier.issue2-
dc.identifier.spagee1004048-
dc.identifier.epagee1004048-
dc.identifier.isiWOS:000352081000018-
dc.publisher.placeUnited States-

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