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Article: The association between macular thickness and peripapillary retinal nerve fiber layer thickness in chinese children

TitleThe association between macular thickness and peripapillary retinal nerve fiber layer thickness in chinese children
Authors
Issue Date2015
Citation
Medicine (Baltimore), 2015, v. 94 n. 8, p. e567-e567 How to Cite?
AbstractTo investigate the association between macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in Chinese children.This cross-sectional study recruited consecutive cases of healthy pediatric subjects aged 4 to 18 from Caritas Medical Centre in Hong Kong Special Administrative Region, China, from 2013 to 2014. Subjects with only eye, ocular tumors, congenital glaucoma, congenital cataract, congenital nystagmus, microphthalmos, optic nerve or retinal disease, active ocular infections, corneal scars, and severe visual impairment of any cause were excluded. Peripapillary RNFL thickness and macular thickness at 1-mm-diameter fovea center (C1), 3-mm-diameter temporal quadrant (T3), and 3-mm- diameter nasal quadrant (N3) were measured with optical coherence tomography. Best-corrected visual acuity, axial length, and cycloplegic refraction were also recorded. Spearman correlation was used to analyze the association between T3, C1, and N3 with each of the following: average and quadrant RNFL thickness, axial length, and spherical equivalent.In 179 subjects, the mean age was 7.9 +/- 3.6 years. There were 90 male and 89 female subjects, all of Chinese ethnicity. The mean spherical equivalent was -0.1 +/- 3.1 D and mean axial length was 22.9 +/- 1.4 mm. There were significant and positive correlations of the average (T3: r = 0.20, P = 0.04; N3: r = 0.2, P = 0.005), superior (T3: r = 0.20, P = 0.03; N3: r = 0.2, P = 0.03), and inferior (T3: r = 0.20, P = 0.02; N3: r = 0.2, P = 0.01) peripapillary RNFL thicknesses with the T3 and N3 macular thicknesses but not C1. The nasal peripapillary RNFL thickness was also positively correlated with T3 (r = 0.20, P = 0.01). There were no significant associations between the macular thickness (T3, C1, N3) with neither the spherical equivalent (P > 0.2) nor the axial length (P > 0.3).The macular thickness was positive correlated with the peripapillary RNFL thickness in a population of healthy Chinese children.
Persistent Identifierhttp://hdl.handle.net/10722/208502
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLee, WYJen_US
dc.contributor.authorYau, GSen_US
dc.contributor.authorWoo, TTen_US
dc.contributor.authorLai, JSen_US
dc.date.accessioned2015-03-11T07:06:27Z-
dc.date.available2015-03-11T07:06:27Z-
dc.date.issued2015en_US
dc.identifier.citationMedicine (Baltimore), 2015, v. 94 n. 8, p. e567-e567en_US
dc.identifier.issn1536-5964en_US
dc.identifier.urihttp://hdl.handle.net/10722/208502-
dc.description.abstractTo investigate the association between macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in Chinese children.This cross-sectional study recruited consecutive cases of healthy pediatric subjects aged 4 to 18 from Caritas Medical Centre in Hong Kong Special Administrative Region, China, from 2013 to 2014. Subjects with only eye, ocular tumors, congenital glaucoma, congenital cataract, congenital nystagmus, microphthalmos, optic nerve or retinal disease, active ocular infections, corneal scars, and severe visual impairment of any cause were excluded. Peripapillary RNFL thickness and macular thickness at 1-mm-diameter fovea center (C1), 3-mm-diameter temporal quadrant (T3), and 3-mm- diameter nasal quadrant (N3) were measured with optical coherence tomography. Best-corrected visual acuity, axial length, and cycloplegic refraction were also recorded. Spearman correlation was used to analyze the association between T3, C1, and N3 with each of the following: average and quadrant RNFL thickness, axial length, and spherical equivalent.In 179 subjects, the mean age was 7.9 +/- 3.6 years. There were 90 male and 89 female subjects, all of Chinese ethnicity. The mean spherical equivalent was -0.1 +/- 3.1 D and mean axial length was 22.9 +/- 1.4 mm. There were significant and positive correlations of the average (T3: r = 0.20, P = 0.04; N3: r = 0.2, P = 0.005), superior (T3: r = 0.20, P = 0.03; N3: r = 0.2, P = 0.03), and inferior (T3: r = 0.20, P = 0.02; N3: r = 0.2, P = 0.01) peripapillary RNFL thicknesses with the T3 and N3 macular thicknesses but not C1. The nasal peripapillary RNFL thickness was also positively correlated with T3 (r = 0.20, P = 0.01). There were no significant associations between the macular thickness (T3, C1, N3) with neither the spherical equivalent (P > 0.2) nor the axial length (P > 0.3).The macular thickness was positive correlated with the peripapillary RNFL thickness in a population of healthy Chinese children.en_US
dc.languageengen_US
dc.relation.ispartofMedicine (Baltimore)en_US
dc.titleThe association between macular thickness and peripapillary retinal nerve fiber layer thickness in chinese childrenen_US
dc.typeArticleen_US
dc.identifier.emailLee, WYJ: jackylee@hku.hken_US
dc.identifier.authorityLee, WYJ=rp01498en_US
dc.identifier.doi10.1097/MD.0000000000000567en_US
dc.identifier.pmid25715254-
dc.identifier.volume94en_US
dc.identifier.issue8en_US
dc.identifier.spagee567en_US
dc.identifier.epagee567en_US

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