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Article: Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population

TitleGenetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population
Authors
KeywordsAdult
Asian Continental Ancestry Group/*ethnology/*genetics/statistics & numerical data
Chromosomes, Human, Pair 5/genetics
Cluster Analysis
Computer Simulation/statistics & numerical data
Female
Genetic Predisposition to Disease/epidemiology/*genetics
*Genetic Testing/statistics & numerical data
Genetic Variation/genetics
Genetics, Population/methods/statistics & numerical data
Humans
Male
Polymorphism, Single Nucleotide/genetics
Schizophrenia/epidemiology/*genetics
Issue Date2004
Citation
Genome Research, 2004, v. 14 n. 7, p. 1345-1349 How to Cite?
AbstractThe Chinese Han population, the largest population in the world, has traditionally been geographically divided into two parts, the Southern Han and Northern Han. In practice, however, these commonly used ethnic labels are both insufficient and inaccurate as descriptors of inferred genetic clustering, and can lead to the observation of "spurious association" as well as the concealment of real association. In this study, we attempted to address this problem by using 14 microsatellite markers to reconstruct the population genetic structure in 768 Han Chinese samples, including 384 Southern Han and 384 Northern Han, and in samples from Chinese minorities including 48 Yao and 48 BouYei subjects. Furthermore, with a dense set of markers around the region 5q34-35, we built fine-scale haplotype networks for each population/subpopulation and tested for association to schizophrenia susceptibility. We found that more variants in SLIT3 tend to associate with schizophrenia susceptibility in the genetically structured samples, compared to geographically structured samples and samples without identified population substructure. Our results imply that identifying the hidden genetic substructure adds power when detecting association, and suggest that SLIT3 or a nearby gene is associated with schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/208438
ISSN
2015 Impact Factor: 11.351
2015 SCImago Journal Rankings: 14.352
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorShi, Yen_US
dc.contributor.authorZhao, Xen_US
dc.contributor.authorYu, Len_US
dc.contributor.authorTao, Ren_US
dc.contributor.authorTang, Jen_US
dc.contributor.authorLa, Yen_US
dc.contributor.authorDuan, Yen_US
dc.contributor.authorGao, Ben_US
dc.contributor.authorGu, Nen_US
dc.contributor.authorXu, Yen_US
dc.contributor.authorFeng, Gen_US
dc.contributor.authorZhu, Sen_US
dc.contributor.authorLiu, Hen_US
dc.contributor.authorSalter, Hen_US
dc.contributor.authorHe, Len_US
dc.date.accessioned2015-03-11T03:00:58Z-
dc.date.available2015-03-11T03:00:58Z-
dc.date.issued2004en_US
dc.identifier.citationGenome Research, 2004, v. 14 n. 7, p. 1345-1349en_US
dc.identifier.issn1088-9051en_US
dc.identifier.urihttp://hdl.handle.net/10722/208438-
dc.description.abstractThe Chinese Han population, the largest population in the world, has traditionally been geographically divided into two parts, the Southern Han and Northern Han. In practice, however, these commonly used ethnic labels are both insufficient and inaccurate as descriptors of inferred genetic clustering, and can lead to the observation of "spurious association" as well as the concealment of real association. In this study, we attempted to address this problem by using 14 microsatellite markers to reconstruct the population genetic structure in 768 Han Chinese samples, including 384 Southern Han and 384 Northern Han, and in samples from Chinese minorities including 48 Yao and 48 BouYei subjects. Furthermore, with a dense set of markers around the region 5q34-35, we built fine-scale haplotype networks for each population/subpopulation and tested for association to schizophrenia susceptibility. We found that more variants in SLIT3 tend to associate with schizophrenia susceptibility in the genetically structured samples, compared to geographically structured samples and samples without identified population substructure. Our results imply that identifying the hidden genetic substructure adds power when detecting association, and suggest that SLIT3 or a nearby gene is associated with schizophrenia.en_US
dc.languageengen_US
dc.relation.ispartofGenome Researchen_US
dc.subjectAdulten_US
dc.subjectAsian Continental Ancestry Group/*ethnology/*genetics/statistics & numerical dataen_US
dc.subjectChromosomes, Human, Pair 5/geneticsen_US
dc.subjectCluster Analysisen_US
dc.subjectComputer Simulation/statistics & numerical dataen_US
dc.subjectFemaleen_US
dc.subjectGenetic Predisposition to Disease/epidemiology/*geneticsen_US
dc.subject*Genetic Testing/statistics & numerical dataen_US
dc.subjectGenetic Variation/geneticsen_US
dc.subjectGenetics, Population/methods/statistics & numerical dataen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectPolymorphism, Single Nucleotide/geneticsen_US
dc.subjectSchizophrenia/epidemiology/*geneticsen_US
dc.titleGenetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han populationen_US
dc.typeArticleen_US
dc.identifier.emailGao, B: gaobo@hku.hken_US
dc.identifier.authorityGao, B=rp02012en_US
dc.identifier.doi10.1101/gr.1758204en_US
dc.identifier.pmid15231749-
dc.identifier.pmcid442150-
dc.identifier.scopuseid_2-s2.0-3543089284-
dc.identifier.volume14en_US
dc.identifier.issue7en_US
dc.identifier.spage1345en_US
dc.identifier.epage1349en_US

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