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Conference Paper: Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function

TitleAlternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function
Authors
Issue Date2015
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
The 20th Medical Research Conference (MRC 2015), Department of Medicine, The University of Hong Kong, Hong Kong, 17 January 2015. In Hong Kong Medical Journal, 2015, v. 21 n. 1, suppl. 1, p. 55, abstract no. 90 How to Cite?
AbstractBACKGROUND: Tolerogenic dendritic cells (DCs) are potential cell-based therapy in autoimmune diseases. METHODS: In this study, we generated alternatively activated DCs (aaDCs) by treating monocyte-derived DCs from patients with systemic lupus erythematosus (SLE) and healthy subjects with combination of 1,25 dihydroxyvitamin D(3) (vitD3) and dexamethasone followed by lipopolysaccharide-induced maturation. RESULTS: Lupus aaDCs were found to acquire semi-mature phenotype that remained maturation-resistant to immunostimulants. They produced low level of interleukin-12 (IL-12) but high level of IL-10. They had …
Persistent Identifierhttp://hdl.handle.net/10722/208310
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorWu, H-
dc.contributor.authorLo, Y-
dc.contributor.authorLuk, TW-
dc.contributor.authorLau, CS-
dc.contributor.authorLu, LW-
dc.contributor.authorMok, MY-
dc.date.accessioned2015-02-23T08:22:07Z-
dc.date.available2015-02-23T08:22:07Z-
dc.date.issued2015-
dc.identifier.citationThe 20th Medical Research Conference (MRC 2015), Department of Medicine, The University of Hong Kong, Hong Kong, 17 January 2015. In Hong Kong Medical Journal, 2015, v. 21 n. 1, suppl. 1, p. 55, abstract no. 90-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/208310-
dc.description.abstractBACKGROUND: Tolerogenic dendritic cells (DCs) are potential cell-based therapy in autoimmune diseases. METHODS: In this study, we generated alternatively activated DCs (aaDCs) by treating monocyte-derived DCs from patients with systemic lupus erythematosus (SLE) and healthy subjects with combination of 1,25 dihydroxyvitamin D(3) (vitD3) and dexamethasone followed by lipopolysaccharide-induced maturation. RESULTS: Lupus aaDCs were found to acquire semi-mature phenotype that remained maturation-resistant to immunostimulants. They produced low level of interleukin-12 (IL-12) but high level of IL-10. They had …-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAlternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function-
dc.typeConference_Paper-
dc.identifier.emailLo, Y: yloa@hkucc.hku.hk-
dc.identifier.emailLau, CS: cslau@hku.hk-
dc.identifier.emailMok, MY: temy@hkucc.hku.hk-
dc.identifier.authorityLau, CS=rp01348-
dc.identifier.authorityMok, MY=rp00490-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros242360-
dc.identifier.volume21-
dc.identifier.issue1, suppl. 1-
dc.identifier.spage55, abstract no. 90-
dc.identifier.epage55, abstract no. 90-
dc.publisher.placeHong Kong-

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