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Article: Association of lower habitual physical activity level with mitochondrial and endothelial dysfunction in patients with stable coronary artery disease

TitleAssociation of lower habitual physical activity level with mitochondrial and endothelial dysfunction in patients with stable coronary artery disease
Authors
KeywordsAged
Blood Glucose/metabolism
Coronary Artery Disease/*blood/drug therapy/pathology/physiopathology
Endothelium, Vascular/*metabolism/pathology/physiopathology
Female
Humans
Lactic Acid/blood
*Life Style
Lipids/blood
Male
Middle Aged
Mitochondria/*metabolism/pathology
*Motor Activity
Pyruvic Acid/blood
Risk Factors
Issue Date2012
Citation
Circ J, 2012, v. 76 n. 11, p. 2572-2578 How to Cite?
AbstractBACKGROUND: Exercise training improves endothelial function in patients with coronary artery disease (CAD) through unclear mechanisms. We hypothesized that mitochondrial dysfunction related to a lower habitual physical activity level (PAL) is associated with endothelial dysfunction. METHODS AND RESULTS: We assessed habitual PAL by a validated International Physical Activity Questionnaire, brachial flow-mediated dilation (FMD) and serum lactate, pyruvate, fasting glucose and lipid profiles in 105 CAD patients (age 68+/-10; 87% men). As defined by the lactate/pyruvate ratio (LP ratio) >/=75(th) percentile of the age-and sex-matched controls (ie, >/=18), mitochondrial dysfunction was observed in 33/105 (31%) patients. With decreasing PAL tertiles, there were significant linear trends of lower FMD (P=0.004) and higher LP ratio (P=0.009). Multivariate logistic regression found that the lowest compared with the highest PAL tertile (adjusted odds ratio=3.78, P=0.02) had more patients with high LP ratio. After adjustment for cardiovascular risk factors and medications, the lowest compared to the highest PAL tertile had significantly lower FMD (absolute decrease 1.25%, P=0.03); and high LP ratio was associated with impaired FMD (absolute reduction 1.09%, P=0.03). CONCLUSIONS: In CAD patients, a lower level of habitual PAL is associated with impaired FMD and increased prevalence of mitochondrial dysfunction as defined by high LP ratio. Moreover, high LP ratio predicts a lower FMD, suggesting that the occurrence of mitochondrial dysfunction with lower habitual PAL is associated with endothelial dysfunction in CAD patients.
Persistent Identifierhttp://hdl.handle.net/10722/207695
ISSN
2015 Impact Factor: 4.124
2015 SCImago Journal Rankings: 1.728

 

DC FieldValueLanguage
dc.contributor.authorLuk, THen_US
dc.contributor.authorDai, YLen_US
dc.contributor.authorSiu, DCWen_US
dc.contributor.authorYiu, KHen_US
dc.contributor.authorLi, SWen_US
dc.contributor.authorFong, Ben_US
dc.contributor.authorWong, WKen_US
dc.contributor.authorTam, Sen_US
dc.contributor.authorTse, HFen_US
dc.date.accessioned2015-01-19T04:20:34Z-
dc.date.available2015-01-19T04:20:34Z-
dc.date.issued2012en_US
dc.identifier.citationCirc J, 2012, v. 76 n. 11, p. 2572-2578en_US
dc.identifier.issn1346-9843en_US
dc.identifier.urihttp://hdl.handle.net/10722/207695-
dc.description.abstractBACKGROUND: Exercise training improves endothelial function in patients with coronary artery disease (CAD) through unclear mechanisms. We hypothesized that mitochondrial dysfunction related to a lower habitual physical activity level (PAL) is associated with endothelial dysfunction. METHODS AND RESULTS: We assessed habitual PAL by a validated International Physical Activity Questionnaire, brachial flow-mediated dilation (FMD) and serum lactate, pyruvate, fasting glucose and lipid profiles in 105 CAD patients (age 68+/-10; 87% men). As defined by the lactate/pyruvate ratio (LP ratio) >/=75(th) percentile of the age-and sex-matched controls (ie, >/=18), mitochondrial dysfunction was observed in 33/105 (31%) patients. With decreasing PAL tertiles, there were significant linear trends of lower FMD (P=0.004) and higher LP ratio (P=0.009). Multivariate logistic regression found that the lowest compared with the highest PAL tertile (adjusted odds ratio=3.78, P=0.02) had more patients with high LP ratio. After adjustment for cardiovascular risk factors and medications, the lowest compared to the highest PAL tertile had significantly lower FMD (absolute decrease 1.25%, P=0.03); and high LP ratio was associated with impaired FMD (absolute reduction 1.09%, P=0.03). CONCLUSIONS: In CAD patients, a lower level of habitual PAL is associated with impaired FMD and increased prevalence of mitochondrial dysfunction as defined by high LP ratio. Moreover, high LP ratio predicts a lower FMD, suggesting that the occurrence of mitochondrial dysfunction with lower habitual PAL is associated with endothelial dysfunction in CAD patients.en_US
dc.languageengen_US
dc.relation.ispartofCirc Jen_US
dc.subjectAgeden_US
dc.subjectBlood Glucose/metabolismen_US
dc.subjectCoronary Artery Disease/*blood/drug therapy/pathology/physiopathologyen_US
dc.subjectEndothelium, Vascular/*metabolism/pathology/physiopathologyen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectLactic Acid/blooden_US
dc.subject*Life Styleen_US
dc.subjectLipids/blooden_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectMitochondria/*metabolism/pathologyen_US
dc.subject*Motor Activityen_US
dc.subjectPyruvic Acid/blooden_US
dc.subjectRisk Factorsen_US
dc.titleAssociation of lower habitual physical activity level with mitochondrial and endothelial dysfunction in patients with stable coronary artery diseaseen_US
dc.typeArticleen_US
dc.identifier.emailYiu, KH: khkyiu@hku.hken_US
dc.identifier.authorityYiu, KH=rp01490en_US
dc.identifier.volume76en_US
dc.identifier.issue11en_US
dc.identifier.spage2572en_US
dc.identifier.epage2578en_US

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