File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Nicotine and gastrointestinal disorders: Its role in ulceration and cancer development

TitleNicotine and gastrointestinal disorders: Its role in ulceration and cancer development
Authors
KeywordsColon cancer
Adrenergic receptors
Angiogenesis
Cigarette smoke
Crohn's disease
EMT
Gastric cancer
Gastric ulceration
miRNA
nAChRs
Nicotine
NNK
Ulcerative colitis
Issue Date2013
Citation
Current Pharmaceutical Design, 2013, v. 19, n. 1, p. 5-10 How to Cite?
AbstractCigarette smoke has always been the single most preventive cause of death in the world. In 2011, over 460,000 died from cigarette smoke-related diseases in US. The detrimental effects of cigarette smoke on human beings are due to the presence of many carcinogens and other components (e.g. nicotine and tar). Nicotine is now accepted as one of the major components responsible for gastrointestinal disorders. Cigarette smoking, nicotine and a nicotine-derived nitrosamine, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are considered as risk factors for gastrointestinal cancer, however, the underlying mechanism remains largely unknown. Previous studies reported that cigarette smoke and nicotine aggravated inflammation not only in the stomach, but also in the colon. The carcinogenic actions of cigarette smoke, nicotine and NNK on gastrointestinal cancers development have been widely studied. The strong association of cyclooxygenase-2 (COX-2) with gastrointestinal diseases has been extensively studied, however, due to the unresolved cardiovascular risk, it is of great importance to develop other new anti-cancer drugs for the treatment of cancers. This current review aims to provide an overview of the effects of cigarette smoke, nicotine and NNK on gastrointestinal inflammation, and also the carcinogenic properties in cancer development (tumor growth, angiogenesis and epithelial-mesenchymal transition). In addition, current studies on nicotinic acetylcholine receptors, adrenergic receptors and miRNAs in nicotine-related cancer pathogenesis are also highlighted. © 2013 Bentham Science Publishers.
Persistent Identifierhttp://hdl.handle.net/10722/207524
ISSN
2015 Impact Factor: 3.052
2015 SCImago Journal Rankings: 1.220

 

DC FieldValueLanguage
dc.contributor.authorChu, Kent Man-
dc.contributor.authorCho, Chihin-
dc.contributor.authorShin, Vivianyvonne-
dc.date.accessioned2014-12-31T01:01:49Z-
dc.date.available2014-12-31T01:01:49Z-
dc.date.issued2013-
dc.identifier.citationCurrent Pharmaceutical Design, 2013, v. 19, n. 1, p. 5-10-
dc.identifier.issn1381-6128-
dc.identifier.urihttp://hdl.handle.net/10722/207524-
dc.description.abstractCigarette smoke has always been the single most preventive cause of death in the world. In 2011, over 460,000 died from cigarette smoke-related diseases in US. The detrimental effects of cigarette smoke on human beings are due to the presence of many carcinogens and other components (e.g. nicotine and tar). Nicotine is now accepted as one of the major components responsible for gastrointestinal disorders. Cigarette smoking, nicotine and a nicotine-derived nitrosamine, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are considered as risk factors for gastrointestinal cancer, however, the underlying mechanism remains largely unknown. Previous studies reported that cigarette smoke and nicotine aggravated inflammation not only in the stomach, but also in the colon. The carcinogenic actions of cigarette smoke, nicotine and NNK on gastrointestinal cancers development have been widely studied. The strong association of cyclooxygenase-2 (COX-2) with gastrointestinal diseases has been extensively studied, however, due to the unresolved cardiovascular risk, it is of great importance to develop other new anti-cancer drugs for the treatment of cancers. This current review aims to provide an overview of the effects of cigarette smoke, nicotine and NNK on gastrointestinal inflammation, and also the carcinogenic properties in cancer development (tumor growth, angiogenesis and epithelial-mesenchymal transition). In addition, current studies on nicotinic acetylcholine receptors, adrenergic receptors and miRNAs in nicotine-related cancer pathogenesis are also highlighted. © 2013 Bentham Science Publishers.-
dc.languageeng-
dc.relation.ispartofCurrent Pharmaceutical Design-
dc.subjectColon cancer-
dc.subjectAdrenergic receptors-
dc.subjectAngiogenesis-
dc.subjectCigarette smoke-
dc.subjectCrohn's disease-
dc.subjectEMT-
dc.subjectGastric cancer-
dc.subjectGastric ulceration-
dc.subjectmiRNA-
dc.subjectnAChRs-
dc.subjectNicotine-
dc.subjectNNK-
dc.subjectUlcerative colitis-
dc.titleNicotine and gastrointestinal disorders: Its role in ulceration and cancer development-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/1381612811306010005-
dc.identifier.pmid22950507-
dc.identifier.scopuseid_2-s2.0-84873952954-
dc.identifier.hkuros213027-
dc.identifier.hkuros212898-
dc.identifier.volume19-
dc.identifier.issue1-
dc.identifier.spage5-
dc.identifier.epage10-
dc.identifier.eissn1873-4286-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats