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- Publisher Website: 10.1016/j.tox.2004.06.004
- Scopus: eid_2-s2.0-4444354992
- PMID: 15363593
- WOS: WOS:000224332700017
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Article: Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking
Title | Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking |
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Authors | |
Keywords | Cigarette smoking Angiogenesis 5-Lipoxygenase Dextran sulfate sodium Colon cancer |
Issue Date | 2004 |
Citation | Toxicology, 2004, v. 203, n. 1-3, p. 179-188 How to Cite? |
Abstract | Our previous study shows that cigarette smoking can promote inflammation-associated adenoma formation in the mouse colon, but the underling mechanism remains unknown. Several studies suggest that there is a link between 5-lipoxygenase (5-LOX) and carcinogenesis in humans and animals. In the present study, we aims to investigate whether the promoting action of cigarette smoke on inflammation-associated colon cancer formation is associated with 5-LOX activation in mice. Results showed that exposure to the mainstream smoke of unfiltered cigarettes enhanced the 5-LOX protein expression in the inflammation-associated colonic adenomas. It was accompanied with an up-regulation of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF). Both are the key angiogenic factors for tumorigenesis. 5-LOX inhibitors decreased the incidence of colonic adenoma formation and reduced angiogenesis, MMP-2 activity and VEGF protein expression in the colons of these animals. Taken together, these results strongly suggest that cigarette smoke can induce 5-LOX expression which plays an important role in activation of MMP-2 and VEGF to induce angiogenic process and promotion of inflammation-associated adenoma formation in mice. © 2004 Elsevier Ireland Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/207511 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 1.014 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ye, Yini | - |
dc.contributor.author | Liu, Edgar Shiu Lam | - |
dc.contributor.author | Shin, Vivianyvonne | - |
dc.contributor.author | Wu, William Ka Kei | - |
dc.contributor.author | Cho, Chihin | - |
dc.date.accessioned | 2014-12-31T01:01:48Z | - |
dc.date.available | 2014-12-31T01:01:48Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Toxicology, 2004, v. 203, n. 1-3, p. 179-188 | - |
dc.identifier.issn | 0300-483X | - |
dc.identifier.uri | http://hdl.handle.net/10722/207511 | - |
dc.description.abstract | Our previous study shows that cigarette smoking can promote inflammation-associated adenoma formation in the mouse colon, but the underling mechanism remains unknown. Several studies suggest that there is a link between 5-lipoxygenase (5-LOX) and carcinogenesis in humans and animals. In the present study, we aims to investigate whether the promoting action of cigarette smoke on inflammation-associated colon cancer formation is associated with 5-LOX activation in mice. Results showed that exposure to the mainstream smoke of unfiltered cigarettes enhanced the 5-LOX protein expression in the inflammation-associated colonic adenomas. It was accompanied with an up-regulation of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF). Both are the key angiogenic factors for tumorigenesis. 5-LOX inhibitors decreased the incidence of colonic adenoma formation and reduced angiogenesis, MMP-2 activity and VEGF protein expression in the colons of these animals. Taken together, these results strongly suggest that cigarette smoke can induce 5-LOX expression which plays an important role in activation of MMP-2 and VEGF to induce angiogenic process and promotion of inflammation-associated adenoma formation in mice. © 2004 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Toxicology | - |
dc.subject | Cigarette smoking | - |
dc.subject | Angiogenesis | - |
dc.subject | 5-Lipoxygenase | - |
dc.subject | Dextran sulfate sodium | - |
dc.subject | Colon cancer | - |
dc.title | Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.tox.2004.06.004 | - |
dc.identifier.pmid | 15363593 | - |
dc.identifier.scopus | eid_2-s2.0-4444354992 | - |
dc.identifier.volume | 203 | - |
dc.identifier.issue | 1-3 | - |
dc.identifier.spage | 179 | - |
dc.identifier.epage | 188 | - |
dc.identifier.isi | WOS:000224332700017 | - |
dc.identifier.issnl | 0300-483X | - |