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Article: Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract

TitleCyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract
Authors
KeywordsCigarette smoke
Cyclooxygenase-2
Colon cancer
Issue Date2005
Citation
European Journal of Pharmacology, 2005, v. 518, n. 1, p. 47-55 How to Cite?
AbstractCigarette smoking, cyclooxygenase-2 (COX-2) and macrophages are independently associated with colorectal cancer. In the present study, cigarette smoke ethanol extract was applied to colon cancer cells (SW1116) or indirectly via activated macrophages (THP-1 cells) to attest their effects on cancer cell proliferation and tumor growth both in vitro and in vivo. Ethanol extract induced COX-2 expression in SW1116 and THP-1 cells. Combination of THP-1 pre-incubated medium and ethanol extract further potentiated COX-2 expression and proliferation of SW1116 cells. Tumor growth in nude mice was positively associated with the medium and/or ethanol extract treatments, together with the up-regulation of cell proliferation and angiogenesis, and down-regulation of apoptosis. Application of a COX-2 inhibitor (SC236) reduced tumor growth as well as cell proliferation and angiogenesis. These actions are partially depended on the decrease of COX-2 expression. Taken together, inhibition of COX-2 activity may have significant implication to prevent colon cancer in smokers. © 2005 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/207504
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115

 

DC FieldValueLanguage
dc.contributor.authorLiu, Edgar Shiu Lam-
dc.contributor.authorShin, Vivianyvonne-
dc.contributor.authorYe, Yini-
dc.contributor.authorLuo, Jiingchyuan-
dc.contributor.authorWu, William Ka Kei-
dc.contributor.authorCho, Chihin-
dc.date.accessioned2014-12-31T01:01:48Z-
dc.date.available2014-12-31T01:01:48Z-
dc.date.issued2005-
dc.identifier.citationEuropean Journal of Pharmacology, 2005, v. 518, n. 1, p. 47-55-
dc.identifier.issn0014-2999-
dc.identifier.urihttp://hdl.handle.net/10722/207504-
dc.description.abstractCigarette smoking, cyclooxygenase-2 (COX-2) and macrophages are independently associated with colorectal cancer. In the present study, cigarette smoke ethanol extract was applied to colon cancer cells (SW1116) or indirectly via activated macrophages (THP-1 cells) to attest their effects on cancer cell proliferation and tumor growth both in vitro and in vivo. Ethanol extract induced COX-2 expression in SW1116 and THP-1 cells. Combination of THP-1 pre-incubated medium and ethanol extract further potentiated COX-2 expression and proliferation of SW1116 cells. Tumor growth in nude mice was positively associated with the medium and/or ethanol extract treatments, together with the up-regulation of cell proliferation and angiogenesis, and down-regulation of apoptosis. Application of a COX-2 inhibitor (SC236) reduced tumor growth as well as cell proliferation and angiogenesis. These actions are partially depended on the decrease of COX-2 expression. Taken together, inhibition of COX-2 activity may have significant implication to prevent colon cancer in smokers. © 2005 Elsevier B.V. All rights reserved.-
dc.languageeng-
dc.relation.ispartofEuropean Journal of Pharmacology-
dc.subjectCigarette smoke-
dc.subjectCyclooxygenase-2-
dc.subjectColon cancer-
dc.titleCyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejphar.2005.05.018-
dc.identifier.pmid15993407-
dc.identifier.scopuseid_2-s2.0-22044451612-
dc.identifier.volume518-
dc.identifier.issue1-
dc.identifier.spage47-
dc.identifier.epage55-

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