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- Publisher Website: 10.1016/j.ejphar.2005.05.018
- Scopus: eid_2-s2.0-22044451612
- PMID: 15993407
- WOS: WOS:000230874800007
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Article: Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract
Title | Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract |
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Authors | |
Keywords | Cigarette smoke Cyclooxygenase-2 Colon cancer |
Issue Date | 2005 |
Citation | European Journal of Pharmacology, 2005, v. 518, n. 1, p. 47-55 How to Cite? |
Abstract | Cigarette smoking, cyclooxygenase-2 (COX-2) and macrophages are independently associated with colorectal cancer. In the present study, cigarette smoke ethanol extract was applied to colon cancer cells (SW1116) or indirectly via activated macrophages (THP-1 cells) to attest their effects on cancer cell proliferation and tumor growth both in vitro and in vivo. Ethanol extract induced COX-2 expression in SW1116 and THP-1 cells. Combination of THP-1 pre-incubated medium and ethanol extract further potentiated COX-2 expression and proliferation of SW1116 cells. Tumor growth in nude mice was positively associated with the medium and/or ethanol extract treatments, together with the up-regulation of cell proliferation and angiogenesis, and down-regulation of apoptosis. Application of a COX-2 inhibitor (SC236) reduced tumor growth as well as cell proliferation and angiogenesis. These actions are partially depended on the decrease of COX-2 expression. Taken together, inhibition of COX-2 activity may have significant implication to prevent colon cancer in smokers. © 2005 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/207504 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.055 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, Edgar Shiu Lam | - |
dc.contributor.author | Shin, Vivianyvonne | - |
dc.contributor.author | Ye, Yini | - |
dc.contributor.author | Luo, Jiingchyuan | - |
dc.contributor.author | Wu, William Ka Kei | - |
dc.contributor.author | Cho, Chihin | - |
dc.date.accessioned | 2014-12-31T01:01:48Z | - |
dc.date.available | 2014-12-31T01:01:48Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | European Journal of Pharmacology, 2005, v. 518, n. 1, p. 47-55 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | http://hdl.handle.net/10722/207504 | - |
dc.description.abstract | Cigarette smoking, cyclooxygenase-2 (COX-2) and macrophages are independently associated with colorectal cancer. In the present study, cigarette smoke ethanol extract was applied to colon cancer cells (SW1116) or indirectly via activated macrophages (THP-1 cells) to attest their effects on cancer cell proliferation and tumor growth both in vitro and in vivo. Ethanol extract induced COX-2 expression in SW1116 and THP-1 cells. Combination of THP-1 pre-incubated medium and ethanol extract further potentiated COX-2 expression and proliferation of SW1116 cells. Tumor growth in nude mice was positively associated with the medium and/or ethanol extract treatments, together with the up-regulation of cell proliferation and angiogenesis, and down-regulation of apoptosis. Application of a COX-2 inhibitor (SC236) reduced tumor growth as well as cell proliferation and angiogenesis. These actions are partially depended on the decrease of COX-2 expression. Taken together, inhibition of COX-2 activity may have significant implication to prevent colon cancer in smokers. © 2005 Elsevier B.V. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | European Journal of Pharmacology | - |
dc.subject | Cigarette smoke | - |
dc.subject | Cyclooxygenase-2 | - |
dc.subject | Colon cancer | - |
dc.title | Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.ejphar.2005.05.018 | - |
dc.identifier.pmid | 15993407 | - |
dc.identifier.scopus | eid_2-s2.0-22044451612 | - |
dc.identifier.volume | 518 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 47 | - |
dc.identifier.epage | 55 | - |
dc.identifier.isi | WOS:000230874800007 | - |
dc.identifier.issnl | 0014-2999 | - |