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Article: Migration patterns of hepatitis C virus in China characterized for five major subtypes based on samples from 411 volunteer blood donors from 17 provinces and municipalities

TitleMigration patterns of hepatitis C virus in China characterized for five major subtypes based on samples from 411 volunteer blood donors from 17 provinces and municipalities
Authors
Issue Date2014
Citation
Journal of Virology, 2014, v. 88, n. 13, p. 7120-7129 How to Cite?
AbstractWe investigated the migration patterns of hepatitis C virus (HCV) in China. Partial E1 and/or NS5B sequences from 411 volunteer blood donors sampled in 17 provinces and municipalities located in five large regions, the north-northeast, northwest, southwest, central south, and southeast, were characterized. The sequences were classified into eight subtypes (1a, n = 3; 1b, n = 183; 2a, n = 83; 3a, n = 30; 3b, n = 44; 6a, n = 55; 6n, n = 10; 6v, n = 1) and a new subtype candidate. Bayesian evolutionary analysis by sampling trees of the E1 sequences of the five major subtypes revealed distinct migration patterns. Subtype 1b showed four groups: one is prevalent nationwide with possible origins in the north-northeast; two are locally epidemic in the central south and northwest, respectively, and have spread sporadically to other regions; and the fourth one is likely linked to the long-distance dispersion among intravenous drug users from the northwest. Subtype 2a showed two groups: the larger one was mainly restricted to the northwest and seemed to show a trend toward migration via the Silk Road; the smaller one was geographically mixed and may represent descendants of those that spread widely during the contaminated plasma campaign in the 1990s. Subtype 3a exhibited three well-separated geographic groups that may be epidemically unrelated: one showed origins in the northwest, one showed origins in the southwest, and the other showed origins in the central south. In contrast, subtype 3b had a mixture of geographic origins, suggesting migrations from the southwest to the northwest and sporadically to other regions. Structurally resembling the tree for subtype 3a, the tree for subtype 6a showed four groups that may indicate migrations from the central south to southeast, southwest, and northwest. Strikingly, no subtype 6a strain was identified in the north-northeast. © 2014, American Society for Microbiology.
Persistent Identifierhttp://hdl.handle.net/10722/207127
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347

 

DC FieldValueLanguage
dc.contributor.authorLu, Ling-
dc.contributor.authorWang, Min-
dc.contributor.authorXia, Wenjie-
dc.contributor.authorTian, Linwei-
dc.contributor.authorXu, Ru-
dc.contributor.authorLi, Chunhua-
dc.contributor.authorWang, Jingxing-
dc.contributor.authorRong, Xia-
dc.contributor.authorXiong, Huaping-
dc.contributor.authorHuang, Ke-
dc.contributor.authorHuang, Jieting-
dc.contributor.authorNakano, Tatsunori-
dc.contributor.authorBennett, Phillip R.-
dc.contributor.authorZhang, Yong-
dc.contributor.authorZhang, Linqi-
dc.contributor.authorFu, Yongshui-
dc.date.accessioned2014-12-09T04:31:27Z-
dc.date.available2014-12-09T04:31:27Z-
dc.date.issued2014-
dc.identifier.citationJournal of Virology, 2014, v. 88, n. 13, p. 7120-7129-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10722/207127-
dc.description.abstractWe investigated the migration patterns of hepatitis C virus (HCV) in China. Partial E1 and/or NS5B sequences from 411 volunteer blood donors sampled in 17 provinces and municipalities located in five large regions, the north-northeast, northwest, southwest, central south, and southeast, were characterized. The sequences were classified into eight subtypes (1a, n = 3; 1b, n = 183; 2a, n = 83; 3a, n = 30; 3b, n = 44; 6a, n = 55; 6n, n = 10; 6v, n = 1) and a new subtype candidate. Bayesian evolutionary analysis by sampling trees of the E1 sequences of the five major subtypes revealed distinct migration patterns. Subtype 1b showed four groups: one is prevalent nationwide with possible origins in the north-northeast; two are locally epidemic in the central south and northwest, respectively, and have spread sporadically to other regions; and the fourth one is likely linked to the long-distance dispersion among intravenous drug users from the northwest. Subtype 2a showed two groups: the larger one was mainly restricted to the northwest and seemed to show a trend toward migration via the Silk Road; the smaller one was geographically mixed and may represent descendants of those that spread widely during the contaminated plasma campaign in the 1990s. Subtype 3a exhibited three well-separated geographic groups that may be epidemically unrelated: one showed origins in the northwest, one showed origins in the southwest, and the other showed origins in the central south. In contrast, subtype 3b had a mixture of geographic origins, suggesting migrations from the southwest to the northwest and sporadically to other regions. Structurally resembling the tree for subtype 3a, the tree for subtype 6a showed four groups that may indicate migrations from the central south to southeast, southwest, and northwest. Strikingly, no subtype 6a strain was identified in the north-northeast. © 2014, American Society for Microbiology.-
dc.languageeng-
dc.relation.ispartofJournal of Virology-
dc.titleMigration patterns of hepatitis C virus in China characterized for five major subtypes based on samples from 411 volunteer blood donors from 17 provinces and municipalities-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1128/JVI.00414-14-
dc.identifier.scopuseid_2-s2.0-84902001345-
dc.identifier.volume88-
dc.identifier.issue13-
dc.identifier.spage7120-
dc.identifier.epage7129-
dc.identifier.eissn1098-5514-

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