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Article: Methionine oxidation in albumin by fine haze particulate matter: An in vitro and in vivo study

TitleMethionine oxidation in albumin by fine haze particulate matter: An in vitro and in vivo study
Authors
KeywordsProtein structure
Polycyclic aromatic hydrocarbons
Pulmonary
Air pollution
Liquid chromatography-mass spectrometry
Issue Date2014
Citation
Journal of Hazardous Materials, 2014, v. 274, p. 384-391 How to Cite?
AbstractThe potential effects of inhaled fine particulate matter (PM2.5), found in haze episodes, on the oxidation of the proteins in the lungs are not well understood. We investigated the effects of PM2.5 from haze episodes on protein oxidation. PM2.5 was collected from the air pollution in Beijing (BJ), Xian (XA), Xiamen (XM) and Hong Kong (HK) during a period of intensive haze episodes. The chemical characteristics of these samples and their effects on albumin oxidation were investigated. The levels of PM2.5 in BJ and XA were 4-6 times higher than in XM and HK. The concentrations of the polycyclic aromatic hydrocarbons (PAHs) components of the PM2.5 from BJ and XA were 10 times higher than those found in XM and HK. The haze PM2.5 increased oxidative stress. Addition of PM2.5 samples collected from haze episodes to albumin in vitro resulted in oxidation of methionine moieties; nasal instillation of PM2.5 suspensions in mice resulted in oxidation of methionine in the albumin in the bronchoalveolar lavage fluid. The methionine moieties participate in peptide chain crosslinking, and methionine oxidation in the albumin could be attributed to the PAH compounds. Our findings may be helpful in explaining the potential respiratory effects during haze episodes. © 2014 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/207094
ISSN
2015 Impact Factor: 4.836
2015 SCImago Journal Rankings: 1.692

 

DC FieldValueLanguage
dc.contributor.authorLee, Kangyun-
dc.contributor.authorWong, Christina-
dc.contributor.authorChuang, Kaijen-
dc.contributor.authorBien, Mauoying-
dc.contributor.authorCao, Junji-
dc.contributor.authorHan, Yongming-
dc.contributor.authorTian, Linwei-
dc.contributor.authorChang, Chihcheng-
dc.contributor.authorFeng, Pohao-
dc.contributor.authorHo, Kinfai-
dc.contributor.authorChuang, Hsiaochi-
dc.date.accessioned2014-12-09T04:31:23Z-
dc.date.available2014-12-09T04:31:23Z-
dc.date.issued2014-
dc.identifier.citationJournal of Hazardous Materials, 2014, v. 274, p. 384-391-
dc.identifier.issn0304-3894-
dc.identifier.urihttp://hdl.handle.net/10722/207094-
dc.description.abstractThe potential effects of inhaled fine particulate matter (PM2.5), found in haze episodes, on the oxidation of the proteins in the lungs are not well understood. We investigated the effects of PM2.5 from haze episodes on protein oxidation. PM2.5 was collected from the air pollution in Beijing (BJ), Xian (XA), Xiamen (XM) and Hong Kong (HK) during a period of intensive haze episodes. The chemical characteristics of these samples and their effects on albumin oxidation were investigated. The levels of PM2.5 in BJ and XA were 4-6 times higher than in XM and HK. The concentrations of the polycyclic aromatic hydrocarbons (PAHs) components of the PM2.5 from BJ and XA were 10 times higher than those found in XM and HK. The haze PM2.5 increased oxidative stress. Addition of PM2.5 samples collected from haze episodes to albumin in vitro resulted in oxidation of methionine moieties; nasal instillation of PM2.5 suspensions in mice resulted in oxidation of methionine in the albumin in the bronchoalveolar lavage fluid. The methionine moieties participate in peptide chain crosslinking, and methionine oxidation in the albumin could be attributed to the PAH compounds. Our findings may be helpful in explaining the potential respiratory effects during haze episodes. © 2014 Elsevier B.V.-
dc.languageeng-
dc.relation.ispartofJournal of Hazardous Materials-
dc.subjectProtein structure-
dc.subjectPolycyclic aromatic hydrocarbons-
dc.subjectPulmonary-
dc.subjectAir pollution-
dc.subjectLiquid chromatography-mass spectrometry-
dc.titleMethionine oxidation in albumin by fine haze particulate matter: An in vitro and in vivo study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jhazmat.2014.04.029-
dc.identifier.scopuseid_2-s2.0-84899723651-
dc.identifier.volume274-
dc.identifier.spage384-
dc.identifier.epage391-
dc.identifier.eissn1873-3336-

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